Tag: M.W=200-300

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 540516-28-7, name is 2-(Hydroxymethyl)-5-bromobenzimidazole, A new synthetic method of this compound is introduced below., Safety of 2-(Hydroxymethyl)-5-bromobenzimidazole

Example 15. Production of intermediate compounds (l-amino-5-bromo-lH- benzimidazol-2-yl)methanol (compound 17) and (l-amino-6-bromo-lH-benzimidazol-2- yl)methanol (compound 18).The 5(6)-bromo-lH-benzimidazol-2-methanol (16 a, b) (5.2 g, 22.7 mmol), prepared to known methodology, is dissolved in a solution of KOeta (4.8 g, 72.8 mmol) in H2O (40 niL). To the mixture is added under stirring at 400C solution Of NH2OSO3H (6g, 50mmol) in H2O (15 mL), neutralized NaHCO3. Upon the completion of the exothermal reaction the mixture is still incubated at 40-500C for 0.5 h and then cooled to room temperature. The resultant precipitate is filtered and recrystallization is accomplished from water. The mixture of compounds 17 and 18 is obtained in 1 :1 ratio (according to 1H NMR). The mixture of these compounds is crystalline, white.Overall yield: 3.7g (67%). 1H NMR (300 MHz, DMSO-d6): delta ppm 4.73 (4H, s, 2CH2), 5.43 (IH, s, OH), 5.45 (IH, s,OH), 6.01 (2H, s, NH2), 6.03 (2H, s, NH2), 7.31 (IH, d, J- 9Hz, ArH), 7.39 (IH, d, J= 9Hz, ArH), 7.46 (IH, d, J- 9Hz, ArH), 7.53 (IH, d, J= 9Hz, ArH), 7.67 (IH, s, ArH), 7.73 (IH, s, ArH).13C NMR (75 MHz, DMSO-d6): delta ppm 55.81, 55.81, 112.48, 113.46, 114.15, 114.98, 121.46, 122.01, 124.93, 125.36, 135.73, 137.78, 139.62, 141.88, 156.17, 156.48. IR (v, cm”1): 3350, 3313, 3184, 3120 NH2.Analysis (C8H8BrN3O): calcd: C 39.67%, H 3.31 %, N 17.36%; found: C 39.88%, H 3.52%, N 17.46%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53484-16-5, name is 6-Bromo-1-methyl-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Formula: C8H7BrN2

A microwave flask was charged with copper(l) chloride (1.87 g, 18.95 mmol), copper(l) iodide (0.36 g, 1.895 mmol) and 6-bromo-1-rnethyl-benzirnidazole (2.00 g, 9.48 mmol), and the vial was flushed with nitrogen. NMP (18 mL) was added. The flask was heated under microwave irradiation to 200 0C for 1.5 h. The mixture was diluted with ethyl acetate (1.5 L) and a 9:1 saturated aqueous ammonium chloride- ammonium hydroxide solution was added (0.25 L). The mixture was stirred vigorously for 15 min and filtered through celite. The two phases were separated and the organic phase was washed with water (0.2 L*5). The combined organic phase was dried over MgSO4, filtered and concentrated to give a moist pale brown solid, contaminated with NMP. The solid was redissolved in ethyl acetate and washed with water. The organic phase was dried over MgSO4, filtered and concentrated to give 6-chloro-1-methyl-1H-benzo[d]imidazole. ESI- MS: m/z 167.1, (M+H)*.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 1450-93-7, A common heterocyclic compound, 1450-93-7, name is 1H-imidazol-2-amine sulfate(2:1), molecular formula is C6H12N6O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

C. A mixture of 2-((5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-2- oxopiperidin-3-yl)acetic acid (218 mg, 0.63 mmol), 2-aminoimidazole sulfate (83 mg, 0.63 mmol), BOP (278 mg, 0.63 mmol) and N,N-diisopropylethylamine (0.33 mL, 1.89 mmol) in dry DMF (5 mL) was stirred at 60 0C under argon for six hours. The mixture was diluted with water and the resulting solution was extracted with EtOAc (4x). The combined organic layer was washed with brine, dried over MgSO4, filtered and the filtrate was evaporated to dryness. The residue was purified by radial chromatography (0% to 5% methanol in CH2CI2) to give 2-[(5S)- 5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-3-piperidinyl]-N-(2-imid- azolyl)acetamide as a mixture of diastereomers (119 mg, 46%) as a white solid.

The synthetic route of 1450-93-7 has been constantly updated, and we look forward to future research findings.

Application of 15813-07-7, The chemical industry reduces the impact on the environment during synthesis 15813-07-7, name is 5-Iodo-4-methyl-1H-imidazole, I believe this compound will play a more active role in future production and life.

To a stirred solution of 4-lodo-5-methyl-1 H-imidazole (5g, 24mmol) in THF (100mL) cooled to 0C was added sodium hydride (60% dispersed in mineral oil) (1 .06g, 26mmol), the resulting suspension was stirred for 1 hr at this temperature. 2-(Trimethylsilyl)ethoxymethyl chloride (4.25ml_, 24mmol) was added slowly and the solution was allowed to warm to room temperature overnight. Further Sodium hydride (60% dispersed in mineral oil) (0.5 eq) was added and the solution was stirred for 1 .5hr. A small amount of water was added before the the solution was concentrated in vacuo. Water and DCM were added and the solution partitioned. The aqueous layer was washed with further DCM (x2) before the combined organics were passsed through a phase separator and concentrated to dryness in vacuo to afford a dark yellow oil. The residue was dissolved in DCM and purified by flash column chromatography (80g S1O2, 0-50% EtOAc in Heptane). TLC still showed both regioisomers together in all fractions so the fractions were concentrated to dryness in vacuo to afford 2-[(4-iodo-5-methyl-imidazol-1 -yl)methoxy]ethyl-trimethyl-silane and 2-[(5-iodo-4-methyl- imidazol-1 -yl)methoxy]ethyl-trimethyl-silane in a ratio of 1 : 0.6 in favour of the title product (5.59g, 17mmol, 69% yield) as a yellow oil. MS Method 2: RT: 1 .44 min, ES+ m/z 339.1 [M+H]+ and 1 .84 min, ES+ m/z 339.1 [M+H]+ H NMR (400MHz, CDCb) delta/ppm: 7.73 ( s, 1 H, minor), 7.49 (s, 1 H, major), 5.22 (s, 2H, both regioisomers), 3.40-3.50 (m, 2H, both regioisomers), 2.27 (s, 3H, major), 2.26 (s, 3H, minor), 0.85- 0.93 (m, 2H, both regioisomers), 0.03 (s, 9H, both regioisomers).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Iodo-4-methyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 2963-77-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2963-77-1, name is 4-(1H-Benzo[d]imidazol-2-yl)aniline, This compound has unique chemical properties. The synthetic route is as follows.

Example 42: Preparation of 4-(1H-Benzoimidazol-2-yl)-N-[4-(1H-benzoimidazol-2-yl)- PHENYLL-BENZAMIDE (Compound 115) Following Scheme 8, 4-(LH-BENZOIMIDAZOL-2-YL)-BENZOIC acid (60 mg, 0.25 mmol) and carbonyldiimidazole (45 mg, 0.3 mmol) were stirred in DMF (1.0 ml) at 80 C under Ar for 90 minutes. To this solution was added 4-(LH-BENZOIMIDAZOL-2-YL)- PHENYLAMINE (41 mg, 0.26 mmol), and the mixture was stirred at 55 C under Ar for overnight. Water (20 ml) was added after it was cooled to ambient temperature. The solid formed was collected by filtration and was washed with water (3 X 10 ml), and ethyl ether (4 X 10 ml). Recrystallization from acetone (30 ml) gave a white solid as a pure product (20 mg, 0.047 mmol, 23%). MS m/z = 429.98 (M+H) ; 1H NMR delta 13. 11 (s, 1 H), 12.84 (s, 1 H), 10.59 (s, 1 H), 8.35 (d, J=8.4 Hz, 2 H), 8. 17 (m, 4 H), 8.01 (d, J=8.4 Hz, 2 H), 7. 83-7. 51 (m, 4 H), 7.25 (m, 4 H).

The chemical industry reduces the impact on the environment during synthesis 4-(1H-Benzo[d]imidazol-2-yl)aniline. I believe this compound will play a more active role in future production and life.

Reference of 71759-87-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 71759-87-0 as follows.

To compound 62.la (0.280g, 0.866mmol, 1.Oeq) in 1,4- dioxane (5. 6mL) was added 4-iodo- 1-methyl- 1H-imidazole (0.151 g, 0.693mmo1, 0. 8eq), Cs2CO3 (0.566g, 1.73mmol, 2.Oeq). The reaction mixture was degassed for 10 mm. under argon atmosphere, then Pd2(dba)3 (0.079g, 0. l73mmol, 0. leq) and Xantphos (0. bOg, 0. l73mmol, 0.2eq) were added, again degassed for 5 mm. The reaction was stirred at 110 C for 2h. Upon completion, reaction mixture was cooled to r.t., transferred in water and product was extracted with ethyl acetate. Organic layers were combined, washed with brine, dried over Na2SO4 and concentrated in vacuo to obtain crude product. This was purified by combi flash using 2% MeOH in CH2C12 as eluantto obtain pure 62.1 (0.llOg, 47.50%). MS(ES): m/z 220.48 [M]t

According to the analysis of related databases, 71759-87-0, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, molecular formula is C13H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 28890-99-5

c) Intermediate C-3 (2.23 g, 10.9 mmol), benzimidazolo[1,2-a]benzimidazole (2.26 g, 10.9 mmol), and potassium phosphate (2.78 g, 13.1 mmol) were suspended in NMP (66 mL). The mixture was stirred at 150 C for 48 h. After the reaction mixture was cooled at roomtemperature, 66 mL of EtCH and 244 mL of water were added there to give a solid. Thissolid was collected by filtration, and it was purifed by column chromatography on silica geleluting with a mixed solvent of heptane and CHCI3 to yield 1.74 g (4 1%) of compound 1-1as a white solid. LC-MS (mlz) 391

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 28890-99-5, its application will become more common.

Reference of 13275-42-8, A common heterocyclic compound, 13275-42-8, name is 2-(2-Bromophenyl)-1H-benzo[d]imidazole, molecular formula is C13H9BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Equimolar quantity of 2-(2-bromophenyl)-1H-benzo[d] imidazole (2) and aniline derivatives in 45 ml of 1,4-dioxan was refluxed for 14 hr with continuous stirring at 80. The completion of reaction was checked by TLC. The reaction mixture was kept overnight in a refrigerator. The solvent was evaporated and a gummy solid mass was obtained. The gummy solid was then washed with cold water and recrystallized from ethanol and water (4:6) to obtain the compounds (3a-3h).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 73746-45-9, name is 5-Iodo-2-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 73746-45-9

EXAMPLE 11 6-(2-Methyl-1H-imidazol-4-yl)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide 400 mg of 6-trimethylstannyl-N-phenylimidazo[1,2-a]pyridine-2-carboxamide (Intermediate 4), 229 mg of 2-methyl-4-iodo-1H-imidazole, 8 mL of tetrahydrofuran, 9.1 mg of bis(dibenzylideneacetone)palladium and 4.6 mg of tris(2-furyl)phosphine are placed in a microwave tube. The reaction mixture is heated for 50 minutes in a microwave machine set at 130 C. and then concentrated to dryness. The residue is taken up in 3.5 mL of N,N-dimethylformamide and a further 150 mg of 2-methyl-4-iodo-1H-imidazole, 10 mg of bis(dibenzylideneacetone)palladium and 5 mg of tris(2-furyl)phosphine are added, followed by heating again for 40 minutes in a microwave machine set at 120 C. The reaction mixture is filtered, the insoluble matter is rinsed with methanol and dichloromethane and the combined filtrates are concentrated under reduced pressure. The residue is chromatographed on a silica cartridge, eluding with dichloromethane and then with a 90/10 mixture of dichloromethane and methanol. The fractions containing the pure expected product are combined and evaporated to dryness under reduced pressure to give 28 mg of 6-(2-methyl-1H-imidazol-4-yl)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide in the form of a beige-coloured solid.

The synthetic route of 73746-45-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3543-73-5, name is Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, A new synthetic method of this compound is introduced below., SDS of cas: 3543-73-5

[0079] To a solution of 81.3 g (650.6 mmol) 2-bromoethanol, 1 g potassium iodide and 100 g water was added 17.0g (65 mmol) compound (6). The reaction mixture was heated to 65-70 C and held at this temperature for 8 h to 12 h.The pH value of the solution was held between 4.2-5.5 during this period by dropwise addition of a solution of 20.0 g(151.4 mmol) diammonium hydrogen phosphate in 35 g water. The control of pH over the duration of the reaction waseffected through use of a pH electrode. The conversion was followed by HPLC. The reaction was continued until thefraction of compound (7A) was ? 1.5 %. Thereby ca. 8% of compound (7B) had formed and the proportion of compound(7) was ca. 87%. The reaction mixture was subsequently concentrated to dryness at ca. 55-60 C under vacuum. Tothe residue was added 150 g water and, preferably with an alkali metal carbonate, the pH value adjusted to ca. 8.5. Thedesired product (7) was extracted with 200 g methylene chloride or 225 g chloroform, and the organic phase subsequentlywashed with 60 – 80 g water. The organic phase was then concentrated to dryness and the remaining oil or alreadycrystalline residue dissolved in 200 g ethyl acetate or alternatively in 60 g actetonitrile. Compound (7) crystallised at ca.5 C and was filtered under suction, washed with 20 g cold ethyl acetate or alternatively with 15 g cold acetonitrile anddried at 60 -70 C. The yield of compound (7) was 18.3 g (52.4 mmol) with a content of ? 98.2% (80.5 % of theory). Thecrude product contained ?0.6% compound (7A) and compound (7B) respectively as well as 99.2%, wherein compound (7A)was removed below a content of 0.2 % and compound (7B) below 0.3 %. Through the course of the reaction, the contentof compound (7C) was kept below 0.15 %, as this compound can only poorly be removed by recrystallization from theabove described solvents. The overall yield of this step was 76.5% of theory and was thus ca. 12.5% higher than thatdescribed in the procedure using ethylene oxide as according to DD34727 and ca. 31% higher in comparison to thefavoured procedure of W02011079193 involving addition of Huenig?s base.Example 5: Synthesis of ethyl 4-[5-[bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazol-

The synthetic route of 3543-73-5 has been constantly updated, and we look forward to future research findings.