Tag: M.W=200-300

Some common heterocyclic compound, 13275-42-8, name is 2-(2-Bromophenyl)-1H-benzo[d]imidazole, molecular formula is C13H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 13275-42-8

General procedure: 2-(2-Bromophenyl)benzimidazole (2 mmol), guanidine hydrochloride (3 mmol), CuI (5 mol%) and potassium phosphate (6 mmol) were added to DMF in a 50 mL round bottom flask, and refluxed at 100 C for 16 h under nitrogen atmosphere. The reaction was detected by TLC. After the reaction was completed, cooled to room temperature. Then 50 mL of dichloromethane was added and washed by brine. The organic layer was concentrated with evaporator, and the residue was purified by column chromatography on silica gel to give the target compound (A-1 to A-3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 13275-42-8, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, A new synthetic method of this compound is introduced below., Safety of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

To a solution of lactam 133b (110 mg, 0.497 mmol) in THF (2ml) at – 78 0C was added LDA (2M in THF/Heptane, 0.62 ml, 1.244 mmol). The reaction was stirred for 30 min. at – 780C, another 30 min. at -200C. Re-cooled to -780C. 3-methoxy-4- (4-methy.-1H-imidazol-1-yl)benzaldehyde was added as solid. The reaction mixture was stirred for 30 min. The reaction was quenched with sat. NaHCO3, extracted with EtOAc (2X), washed with brine (2X). Dried (MgSO4) and concentrated. The crude product was purified by flash chromatograph (7% MeOH/DCM) to afford compound 15d (110 mg, 50.6%).

The synthetic route of 870837-18-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 13275-42-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13275-42-8 name is 2-(2-Bromophenyl)-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a 5mL screw-capped vial was added 1 (0.3mmol) and 1,3-diketone 2 (0.45mmol), together with CuI (0.006g, 0.03mmol), K3PO4 (0.127g, 0.6mmol), and DMF (3mL). The mixture was stirred at 130C for 24h. The mixture was then cooled to room temperature, and filtered through a short column of silica gel (ethyl acetate) to remove inorganic salts. Removal of the solvent left a crude mixture, which was separated by TLC [silica gel 60 GF254 (Merck), ethyl acetate-hexane (the reaction with acyclic ketones) or dichloromethane-methanol (the reaction with cyclic ketones)] to give desired products 3. Except for known 3o [11h], 3q [11c], 3s [11b] and 3t [10a], all new products prepared by the above procedure were characterized spectroscopically as shown below. Similar treatment of 6 with 2a and work-up (TLC, CH2Cl2/MeOH=99/1) shown above gives 7 in 56% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Bromophenyl)-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Reference of 26576-46-5,Some common heterocyclic compound, 26576-46-5, name is 5-Acetoacetlamino benzimdazolone, molecular formula is C11H9N3O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Dispersion synergist SYN-23; Formation of the dispersion synergist SYN-23 is accomplished by diazotation of compound 30 and subsequent coupling with compound 3 according to the following synthesis scheme: [Show Image] 29.98 mL (0.36 mol) of concentrated hydrochloric acid was added to a suspension of 18.1 g (0.1 mol) of compound 30 in 300 mL methanol. The mixture was cooled to about 0-5C and 8.97 g (0.13 mol) of sodiumnitrite was added. The diazonium-salt was kept at a temperature between 0 and 5C. After 15 minutes the excess of nitrite was neutralized by adding 3.0 g (0.03 mol) of sulfamic acid and a pH of 7 was obtained by adding 25.2 g (0.3 mol) of sodiumcarbonate. While the diazonium-salt was made, 22.1 g (0.1 mol) of compound 3 was dissolved in a mixture of 500 mL methanol and 10.0 mL (0.1 mol) 29% soduimhydroxide-solution. This solution was dropped into the diazonium-salt solution and a yellow suspension appears. The temperature was maintained between 0 and 5C for about 3 hours and the yellow pigment was filtered and washed with methanol. The yield was 88 %.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Acetoacetlamino benzimdazolone, its application will become more common.

These common heterocyclic compound, 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 870837-18-6

Synthesis of (Z)-(S)-4-[(1R,2R)-2-hydroxy-1-(3,4,5-trifluorophenyl)propyl]-2-[1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene]-6-methylmorpholin-3-one A solution of (S)-4-[(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]-2-hydroxy-6-methylmorpholin-3-one (92 mg) and triphenylphosphine hydrobromide (68 mg) in acetonitrile (4 ml) was heated under reflux in a nitrogen atmosphere for one hour. The solvent was evaporated under reduced pressure, and the resulting residue was dissolved in ethanol (4 ml). To this reaction solution, 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde obtained in Example 1 (40 mg) and TEA (0.12 ml) were added, and the reaction solution was stirred in a nitrogen atmosphere at room temperature overnight. The solvent was evaporated under reduced pressure. The resulting residue was dissolved in trifluoroacetic acid (1 ml), and the reaction solution was stirred at room temperature for two hours. The reaction solution is poured into a saturated sodium bicarbonate solution, followed by extraction with ethyl acetate. The organic layer was washed with a saturated sodium bicarbonate solution and brine, and then the solvent was evaporated under reduced pressure. The resulting residue was purified by column chromatography using NH silica gel (heptane:ethyl acetate=1:1 to 0:1) to obtain 61.9 mg of the title compound. 1H-NMR(CDCl3) delta (ppm): 1.33(d,J=6.0 Hz,3H), 1.42(d,J=6.0 Hz,3H), 2.34(s,3H), 3.20(dd,J=9.6,12.8 Hz,1H), 3.61(dd,J=2.4,12.8 Hz,1H), 3.85(s,3H), 4.42-4.52(m,2H), 5.35(d,J=6.8 Hz,1H), 6.85(s,1H), 6.95(s,1H), 7.06-7.15(m,2H), 7.22(d,J=8.0 Hz, 1H), 7.33(dd,J=1.6,8.0 Hz,1H), 7.53(d,J=1.6 Hz,1H), 7.86(s,1H).

The synthetic route of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde has been constantly updated, and we look forward to future research findings.

Application of 53484-16-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53484-16-5, name is 6-Bromo-1-methyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.

Step i: 3-fluoro-4-[(3-methylbenzimidazol-5-yl)amino]benzonitrile A mixture containing 6-bromo-1-methyl-benzimidazole (2.38 mmol), 4-amino-3-fluoro-benzonitrile (3.57 mmol), XPhos (0.95 mmol), Cs2CO3 (7.14 mmol) and Pd(OAc)2 (0.71 mmol) in dry toluene (8 mL) was stirred at 110° C. for approximately 16 h. The mixture was diluted (EtOAc), washed (H2O), dried (Na2SO4) and concentrated to yield the desired product 3-fluoro-4-[(3-methylbenzimidazol-5-yl)amino]benzonitrile.

The chemical industry reduces the impact on the environment during synthesis 6-Bromo-1-methyl-1H-benzo[d]imidazole. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 670-83-7, name is 2,5-Diphenyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 670-83-7, SDS of cas: 670-83-7

Into a 15mL pressure tube, sequentially add 1p (66.1mg, 0.3mmol), dichloromethane (3mL), 2a (84.7mg, 0.45mmol), dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer (4.7mg, 0.0075 mmol) and silver acetate (100.1 mg, 0.6 mmol), then the pressure-resistant tube was sealed and placed in a 100 C. oil bath for 10 h. After the reaction was completed, the mixture was cooled to room temperature, filtered with suction, dried, and separated through a silica gel column (dichloromethane / methanol / acetic acid = 30/1 / 0.1) to obtain 3p (85.4 mg, 70%) as a white solid product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 95470-42-1, These common heterocyclic compound, 95470-42-1, name is Ethyl 2-bromo-4-methyl-1H-imidazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) Ethyl 2-bromo-4-methyl-i H-imidazole-5-carboxylate (1.52 g, 6.0 mmol), (4-chlorobenzo[b]thiophen-3-yl)metha- nol (1.79 g, 9.0 mmol) obtained according to a method described in a literature (for example, WO 2002/066457), and triphenylphosphine (2.36 g, 9.0 mmol) were dissolved in THF (15 mE), a 1.9 M solution of DIAD in toluene (4.73 mE, 9.0 mmol) was added dropwise thereto under cooling at 0°C., and the mixture was stirred at 30°C. for 10 hours. The solvent was distilled away and the residue was purified by colunm chromatography to obtain ethyl 2-bromo-i ((4-chlorobenzo [b]thiophen-3-yl)methyl)-4-methyl- 1 H-imidazole-5-car- boxylate (1.73 g):10138] ?H-NMR (CDC13) oe: 7.72 (1H, d, J=8.3 Hz), 7.41-7.24 (3H, m), 6.15 (2H, s), 4.21 (2H, q, J=7.1 Hz), 2.57 (3H, s), 1.20 (3H, t, J=7.1 Hz);10139] ESI-MS mlz=413 (M+H).

The synthetic route of 95470-42-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 73746-45-9, name is 5-Iodo-2-methyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73746-45-9, COA of Formula: C4H5IN2

Step 1 4-Iodo-2-methyl-1H-imidazole (1.0 g, 4.8 mmol) was dissolved in 10 mL of DMF. Trifluoroethyl p-toluenesulfonate (4.89 g, 19.2 mmol) and cesium carbonate (1.57 g, 4.8 mmol) were added and the mixture was stirred for 18 h in a 50 C. oil bath. The reaction was cooled and taken up in ethyl acetate and water. The layers were separated, and the aqueous layer was extracted twice more with ethyl acetate. The combined organic layers were washed with water and brine, and dried over sodium sulfate. After evaporation, the residue was purified by silica gel chromatography (ethyl acetate/hexanes) to give 0.6 g (43%) of 4-iodo-2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazole. (M+H)+=291.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Iodo-2-methyl-1H-imidazole, and friends who are interested can also refer to it.

621-72-7, name is 2-Benzyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Benzyl-1H-benzo[d]imidazole

Under an oxygen atmosphere, 0.30 mmol of 2-benzylbenzimidazole (1 g) and 2 mL of dimethyl sulfoxide were sequentially added to the Schlenk reaction tube.The reaction was stirred under constant temperature in an IKA (constant temperature heating magnetic stirrer) for 48 h. After the reaction is completed, it is cooled to room temperature. Quenched with distilled water.It was then extracted with ethyl acetate (3 x 20 mL). The organic layers were combined and dried over anhydrous sodium sulfate. Pure target product by column chromatography 2g (52.6mg, 79%).

The synthetic route of 621-72-7 has been constantly updated, and we look forward to future research findings.