M.W=200-300 Archives - Page 53 of 87 - Imidazoles-derivatives

Simple exploration of 4-Iodo-1-methyl-1H-imidazole

The synthetic route of 71759-87-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 71759-87-0, These common heterocyclic compound, 71759-87-0, name is 4-Iodo-1-methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 64.3 (0.400g, 1.23mmol, 1.Oeq) 4-iodo- 1-methyl-1H-imidazole (0.306g, 1.47mmol, 1.2eq) in mixture of MeOH (4mL) and dimethoxymethane (lmL). The reaction mixture was degassed by argon for 30 mm. Tetrakis(triphenylphosphine)palladium (0.141 g, 0.1 22mmol, 0.1 eq), Cesium fluoride (0.61 Og, 4.O4mmol, 3.3eq,) was added into reaction mixture and again reaction mixture was degassed by argon for 30 mm. Further reaction mixture was stirred at 150C for 5h. After completion of reaction, water was added to reaction mixture and extracted with ethyl acetate. Organic layers were combined, dried over Na2SO4 and concentrated in vacuo to obtain crude product. This was purified by column chromatography and compound was eluted in 20% ethyl acetate in hexane to obtain64.4 (0.200g, 58.18 %). MS(ES): m/z 281.35 [M+H]t

The synthetic route of 71759-87-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (869 pag.)WO2018/75937; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Simple exploration of 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 28890-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1.00 g (2.44 mmo) 2-iodo-5-pheny-benzimidazoo[t2-a]benzimidazoe, 610mg (2.93 mmo) 6H-benzimidazoo[1 ,2-a]benzimidazoe, 93 mg (0.49 mmo) copper iodide, 1.59 g (4.489 mmo) caesium carbonate and 113 mg (0.98 mmo) L-proine in 10 m DMSO are stirred at 150 C under nitrogen for 43 h. The reaction mixture is poured into water and the product is fi[tered off. The product is washed with water. Coumn chromatography on silicagel with touene/ethy acetate 19/1 ant than 1/1 gives the product (yied: 220 mg (18%)). 1H NMR (400 MHz, THFd8): &59 (d, J= I 8 Hz, I H), 806-81 3 (m, I H), &OO-8O6 (m, 4H), 781787 (m, IH), 775781 (m, 1H), 772774 (m, IH), 75O769 (m, 4H), 743J.49 (m, IH), 731-742 (m, 4H), 724-730 (m, 2H). MS (APC(pos), m/z): 489 (M+1),

Reference:
Patent; BASF SE; BASF SCHWEIZ AG; SCHAeFER, Thomas; BENEDITO, Flavio Luiz; HEINEMEYER, Ute; LANGER, Nicolle; WOLLEB, Heinz; FIGUEIRA DUARTE, Teresa Marina; WATANABE, Soichi; LENNARTZ, Christian; WAGENBLAST, Gerhard; WOLLEB, Annemarie; BARDON, Kristina; WO2014/9317; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some scientific research about 6-Bromo-1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazole

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 1245649-58-4, name is 6-Bromo-1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1245649-58-4, Recommanded Product: 1245649-58-4

A mixture of compound 6-bromo-l-(tetrahydro-2H-pyran-4-yl)-lH- benzo[d] imidazole (68 mg, 0.243 mmol), l-(3,4-dihydroisoquinolin-2(lH)-yl)-3-((4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyridin-2-yl)amino)propan-2-ol (100 mg, 0.243 mmol), Pd(dppf)Cl2 (17.8 mg, 0.026 mmol) and K2C03 (101 mg, 0.734 mmol) in H20-dioxane (1 mL/ 3 mL) was stirred at 100C under N2 with microwave mediated heating for 15 min. The solvent was then removed by concentration and the crude product purified by pre-HPLC to give the title compound as the formate salt (11.8 mg, yield: 10.1%). 1H NMR (500 MHz, MeOD): delta 8.44 (s, 1H), 7.98 (s, 1H), 7.90 (d, J = 5.6 Hz, 1H), 7.79 (d, J = 8.8 Hz, 1H), 7.63 (d, J = 1.6 Hz, 1H), 7.35-7.27 (m, 3H), 7.21 (d, J = 7.6 Hz, 1H), 7.04-7.02 (m, 2H), 4.82-4.76 (m, 1H), 4.45 (s, 2H), 4.35 (br.s, 1H), 4.18 (dd, J = 4.0, 11.2 Hz, 2H), 3.75-3.52 (m, 6H), 3.33 (br, 2H), 3.23 (br.s, 2H), 2.31-2.15 (m, 4H)ppm; ESI-MS (m/z): 484.3 [M+l] +.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; MUNCHHOF, Michael, John; JIN, Lei; WO2014/100695; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Introduction of a new synthetic route about 6-Bromoisatin

The synthetic route of 6326-79-0 has been constantly updated, and we look forward to future research findings.

Application of 6326-79-0, A common heterocyclic compound, 6326-79-0, name is 6-Bromoisatin, molecular formula is C8H4BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To R4 (500 mg, 2.21 mmol) in acetonitrile (15 mL) is added Mel (0.303 mL, 4.87 mmol) and K2CO3 (1.2 g, 8.68 mmol) and the reaction mixture stirred at 60 C for 45 min DCM and water is added and the aqueous layer extracted twice with DCM, the combined organic layers are washed with brine, dried and concentrated. Yield 65%. m/z 240/242 [M+H]+, rt 0.49 min, LC-MS Method b.

The synthetic route of 6326-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRUNDL, Marc; OOST, Thorsten; PAUTSCH, Alexander; PETERS, Stefan; RIETHER, Doris; WIENEN, Wolfgang; WO2013/41497; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Extended knowledge of 2-(2-Oxopropyl)isoindoline-1,3-dione

The synthetic route of 3416-57-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-(2-Oxopropyl)isoindoline-1,3-dione

EXAMPLE 1 Phthalimidoacetone ethylene ketal A solution of phthalimidoacetone 61.9 g (300 mmole) and ethylene glycol 18.9 g (300 mmole) in 300 ml of benzene in the presence of concentrated sulfuric acid (1 drop) is refluxed with stirring for 24 hours. An additional portion of ethylene glycol (18.9 g., 300 mmole) and p-toluenesulfonic acid (3 mg) is added and refluxing is continued for 65 hours. The reaction mixture is cooled in ice, washed with saturated sodiumchloride solution and dried over anhydrous sodium sulfate. The benzene is removed in vacuo and the residue is crystallized from methanol to give 67 g (90%) of phthalimidoacetone, ethylene ketal as white prisms of melting point 92-94 C.

The synthetic route of 3416-57-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Upjohn Company; US3992408; (1976); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

The important role of 5-(Trifluoromethoxy)indoline-2,3-dione

The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.

Reference of 169037-23-4,Some common heterocyclic compound, 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, molecular formula is C9H4F3NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(a) Step 1 Aqueous sodium hydroxide (0.0888 g, 2.22 mmol, 2 mL) was heated to 50C, and added with 5-trifluoromethoxyisatin (0.500 g, 2.16 mmol). The mixture was stirred at 50C for 1 hour, and then cooled on ice. The reaction mixture was added with sodium nitrite (0.149 g, 2.16 mmol), and then added dropwise with a solution of concentrated sulfuric acid (0.413 g, 4.21 mmol) in ice-cooled water (3.5 mL), and the mixture was stirred for 1 hour under ice cooling. Then, the mixture was added dropwise with an ice-cooled solution of tin(II) chloride dihydrate (1.17 g, 5.18 mmol) in concentrated hydrochloric acid (1.7 mL). The mixture was stirred overnight at room temperature, and then filtered to obtain a pale brown solid (0.638 g).

The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi; EP2565192; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Some tips on 4-Bromoisoindoline hydrochloride

According to the analysis of related databases, 923590-95-8, the application of this compound in the production field has become more and more popular.

Synthetic Route of 923590-95-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 923590-95-8 as follows.

General procedure: 4-Bromoisoindoline hydrochloride (3.0 g, 13 mmol, 1 eq) was suspended in dry DCM (50 ml), and then TEA (5.4 ml, 39 mmol, 3 eq) was added. Reaction mixture was cooled to 0C in an ice-bath, and then benzyl chloroformate (2.7 ml, 19 mmol, 1 .5 eq) dissolved in 10 ml DCM was added dropwise. Reaction was carried out under inert gas (nitrogen) atmosphere while stirring at room temperature for 3h. Reaction mixture was extracted thrice with saturated NaHCC solution, then once with water and with saturated NaCl solution. Organic phase was dried over anhydrous Na2S04, and then concentrated under reduced pressure to obtain white solid which was dried under vacuum. (0165) White solid, yield: 90% (3.8 g), Ci6Hi4BrN02, MW 332.19, monoisotopic mass 331 .02, [M+H]+ 332.2, UPLC Rt = 8.12. 1H NMR (300 MHz, CDCU) d (ppm) 4.73 (dd, J= 1 1 .6, 1 .4 Hz, 2H), 4.79-4.89 (m, 2H), 5.22 (d, J = 2.2 Hz, 2H), 7.09-7.50 (m, 7H).

According to the analysis of related databases, 923590-95-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CELON PHARMA S.A.; UNIWERSYTET JAGIELLONSKI; INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK; KAMINSKI, Krzysztof; GRYCHOWSKA, Katarzyna; CANALE, Vittorio; BOJARSKI, Andrzej J.; SATALA, Grzegorz; LENDA, Tomasz; POPIK, Piotr; MATLOKA, Mikolaj; DUBIEL, Krzysztof; MOSZCZYNSKI-PETKOWSKI, Rafal; PIECZYKOLAN, Jerzy; WIECZOREK, Maciej; ZAJDEL, Pawel; (69 pag.)WO2019/97282; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Now Is The Time For You To Know The Truth About 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 38668-46-1. Formula: C9H13N7.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C9H13N7, 38668-46-1, Name is 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine, molecular formula is C9H13N7, belongs to imidazoles-derivatives compound. In a document, author is Cahyana, A. H., introduce the new discover.

CoFe2O4 Magnetic Catalyst Assisted a Facile One-Pot Multicomponent Construction of 2,4,5-Trisubstituted-1H-Imidazole Derivatives

The 2,4,5-trisubstituted imidazole derivatives have been synthesized via one-pot condensation of benzil aromatic aldehydes and ammonium acetate catalyzed by CoFe2O4 magnetic catalyst. All products were obtained in good yields. The CoFe2O4 magnetic catalyst can be recycled easily and reused without significant decrease in catalytic ability.

Awesome Chemistry Experiments For 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 16079-88-2 is helpful to your research. HPLC of Formula: C5H6BrClN2O2.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 16079-88-2, Name is 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione, SMILES is O=C1N(Cl)C(C(C)(C)N1Br)=O, belongs to imidazoles-derivatives compound. In a document, author is Tatsuma, T, introduce the new discover, HPLC of Formula: C5H6BrClN2O2.

Selective control of sensitivity to imidazole derivatives of interference-based biosensors by use of a phase transition gel

Sensitivity to histidine of an interference-based biosensor coated with a phase transition gel is controlled by swelling and shrinking the gel, while that to imidazole is not changed significantly.

Final Thoughts on Chemistry for 38668-46-1

If you are interested in 38668-46-1, you can contact me at any time and look forward to more communication. Application In Synthesis of 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine.

In an article, author is KNOLKER, HJ, once mentioned the application of 38668-46-1, Application In Synthesis of 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine, Name is 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine, molecular formula is C9H13N7, molecular weight is 219.25, MDL number is MFCD00047350, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

IMIDAZOLE DERIVATIVES .8. STEREOSELECTIVE FORMATION OF 1-[(E)3-(1-IMIDAZOLYL)-2-ALKENOYL]IMIDAZOLES

The reaction of propynoic, 2-butynoic, and 3-butynoic acids with 1,1′-carbonyldiimidazole stereoselectively provides the corresponding 1-[(E) 3-(1-imidazolyl)-2-alkenoyl]imidazoles.