Tag: M.W=200-300

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Application In Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, SMILES is CC1=C[N](C=N1)C2=CC(=CC(=C2)N)C(F)(F)F, belongs to imidazoles-derivatives compound. In a document, author is Wang Shu-Jun, introduce the new discover.

Chiral Zn prophyrin: Thermodynamic properties and theoretical calculation

The thermodynamic properties of chiral zinc prophyrin (ZnP) coordinating with imidazole derivatives were studied by means of UV-Vis and circular dichroism spectra. The binding constants decreased in the order of K(2-MeIm)>K(Im)>K(N-MeIm)>K(2-Et-4-MeIm) for imidazole derivatives. The results show that the capability of axial coordination increases in the sequence of 2-Et-4-MeImApplication In Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 3543-72-4, Name is Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate, molecular formula is C14H17N3O4. In an article, author is Jayabharathi, Jayaraman,once mentioned of 3543-72-4, Product Details of 3543-72-4.

Studies on interaction between an imidazole derivative and bovine serum by spectral methods

The interaction between a trifluoromethyl substituted imidazole derivative 2-(4-(trifluorometh yl)phenyl)-1-phenyl-1H-imidazo[4,5-f] [1,10] phenanthroline (tfmppip) and bovine serum albumin (BSA) was investigated by solution spectral studies. The observed experimental result shows that the imidazole derivative has strong ability to quench the fluorescence of BSA by forming complex which is stabilized by electrostatic interactions. The effective quenching constants (k(sv)) were 2.79 x 10(4), 2.51 x 10(4), and 2.32 x 10(4) at 301, 310 and 318 K respectively. The Stern-Volmer quenching constant (K-sv), binding site number (n), apparent binding constant (K-A) and corresponding thermodynamic parameters (Delta G, Delta H and Delta S) were calculated. The distance between the donor (BSA) and acceptor (tfmppip) was obtained according to fluorescence resonance energy transfer (FRET). Conformational changes of BSA were observed from synchronous fluorescence technique. The effect of metal ions such as Cu2+, Zn2+, Ca2+, Mg2+, Ni2+, Co2+ and Fe2+ on the binding constants between the imidazole derivative and BSA were also studied. (C) 2012 Elsevier B.V. All rights reserved.

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Related Products of 3543-72-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 3543-72-4, Name is Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate, SMILES is O=C(OCC)CCCC1=NC2=CC([N+]([O-])=O)=CC=C2N1C, belongs to imidazoles-derivatives compound. In a article, author is Yang, Shuang, introduce new discover of the category.

Synthesis of maleimide modified imidazole derivatives and their application in one-component epoxy resin systems

A series of novel maleimide modified imidazole derivatives were successfully synthesized through the addition reaction between N-(4-hydroxyphenyl) maleimide (HPM) and imidazole compounds with 1-position N-H bond. The maleimide modified imidazole derivatives were blended with epoxy resin (EP) to evaluate their reactivity and thermal latency. Compared with the common EP/imidazoles systems, the curing exothermic interval of the EP systems containing maleimide modified imidazole derivatives shifted to higher temperature regions. Moreover, the EP systems containing maleimide modified imidazole derivatives had much longer pot life under room temperature. The enhanced latency of maleimide modified imidazole derivatives was attributed to the strong electron withdrawing effect of maleimide group, which reduced the nucleophilicity of imidazole moiety. Notably, the maleimide modified imidazole derivatives regained fast curing ability towards EP by overcoming the curing reaction energy barrier under heating condition. (C) 2018 Elsevier B.V. All rights reserved.

Related Products of 3543-72-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 3543-72-4 is helpful to your research.

Electric Literature of 16079-88-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 16079-88-2, Name is 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione, SMILES is O=C1N(Cl)C(C(C)(C)N1Br)=O, belongs to imidazoles-derivatives compound. In a article, author is Chen, LM, introduce new discover of the category.

Screening novel, potent multidrug-resistant modulators from imidazole derivatives

The overexpression of P-glycoprotein (P-gp) by tumor cells results in multidrug resistance (MDR) to structurally unrelated anticancer drugs. Combined therapy with MDR-related cytotoxins and MDR modulators is a promising strategy to overcome clinical MDR. This study was designed to screen potent MDR modulators from imidazole derivatives. Cytotoxicity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The intracellular accumulation of doxorubicin (Dox) was detected by fluorescence spectrophotometry. The function of P-gp was examined by Rhodamine 123 accumulation detected with flow cytometry (FCM). Among imidazole derivatives, FG020326, FG020327, and FG020318 were found to possess three- to fourfold stronger reversal MDR activity than verapamil, a well-known positive MDR modulator. Imidazole derivatives significantly increased the Dox accumulation and inhibited P-gp function exhibited by the increase of Rhodamine accumulation in MDR cells. The fold reversal of MDR was relative with the increase of Rhodamine accumulation. FG020326, FG020327, and FG020318 showed potent MDR reversal activity in vitro. Their mechanism of MDR reversal is associated with the inhibition of P-gp function and the increase of anticancer accumulation. These results suggest FG020326, FG020327, and FG020318 are promising to further study and develop.

Electric Literature of 16079-88-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 16079-88-2 is helpful to your research.

Reference of 144689-94-1, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 144689-94-1, Name is Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate, SMILES is O=C(C1=C(C(OCC)=O)NC(CCC)=N1)OCC, belongs to imidazoles-derivatives compound. In a article, author is Jia, Jian-Hong, introduce new discover of the category.

Synthesis of Imidazole Derivatives by Cascade Reaction: Base-Mediated Addition/Alkyne Hydroamination of Propargylamines and Carbodiimides

A novel synthesis of 2-iminoimidazoles and 2-aminoimidazoles, via nucleophilic addition and a subsequent sodium hydroxide mediated intramolecular alkyne hydroamination from propargylamines and carbodiimides, is developed. This transition-metal-free cascade process represents an atom-economic and step-economic procedure for the construction of imidazole derivatives with high regioselectivity and moderate to good yields.

Reference of 144689-94-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 144689-94-1.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 3543-72-4, Name is Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate, molecular formula is C14H17N3O4. In an article, author is Hu, Ling,once mentioned of 3543-72-4, Computed Properties of C14H17N3O4.

A molecular probe based on pyrimidine imidazole derivatives for stable super-resolution endoplasmic reticulum imaging in living cells

Multi-functional florescent dyes capable of acting as molecular probes in living systems under two-photon microscopy, as well as super-resolution nanoscopy, are of great interest. Herein, a novel donor–acceptor (D–A) type pyrimidine imidazole derivative with a flexible alkyl chain molecule (EX-1) has been efficiently synthesized through improved Knoevenagel condensation with high yield and relatively large 2PA cross-sections. Furthermore, a cytotoxicity assay and photo-resistance evaluation indicated that such small organic dyes could not only effectively target the endoplasmic reticulum in living cells, but also reveal its ultrastructure under stimulated emission depletion (STED) nanoscopy.

Interested yet? Keep reading other articles of 3543-72-4, you can contact me at any time and look forward to more communication. Computed Properties of C14H17N3O4.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 3543-72-4, Name is Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate, formurla is C14H17N3O4. In a document, author is Jayabharathi, Jayaraman, introducing its new discovery. Recommanded Product: 3543-72-4.

Synthesis, spectral studies and solvatochromic analysis of novel imidazole derivatives

Bioactive imidazole derivatives were synthesized and characterized by spectral techniques. The photophysical properties of imidazole derivatives were studied in several solvents. The observed spectral shift is attributed to a loss of planarity in the excited state provided by the non-co-planarity of the aryl rings attached to C(2) and N(1) atoms of the imidazole ring. The observed solvatochromic shifts were analyzed in detail by Kamlet-Taft and Catalan parameters. The interaction between bioactive imidazole derivative and bovine serum albumin (BSA) was also investigated. (C) 2012 Elsevier B.V. All rights reserved.

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16079-88-2, Name is 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione, molecular formula is C5H6BrClN2O2, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Aydogan, Goezde, once mentioned the new application about 16079-88-2, Application In Synthesis of 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione.

Mutagenic activities of ten imidazole derivatives in Salmonella typhimurium

Ten imidazole derivatives were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100 both in the absence and presence of metabolic activation by the microsomal fraction S9 mix. In a general manner, derivatives tested exhibited a greater mutagenic activity in the TA100 strain comparing to the responses in TA 98. In the standard plate incorporation assay, 8 of these substances (80%) were found to be mutagenic for at least one of the two strains in the presence or absence of metabolic activation. Two compounds showed positive results in TA98 and 6 compounds were also mutagenic in TA100 without S9. In the presence of S9 mix, all of the 10 substances were non-mutagenic in TA98, whereas 4 compounds were positive in TA100. The results suggested the mutagenic potentials of the imidazole derivatives particularly inducing the reversion of base-pair substitutions. According to the structure-activity relationships phenyl groups in position 2 with different substituents can confer the mutagenic activity of the tested compounds. Methyl groups in different positions of these phenyl substituents can cause different types of mutations. This mutagenic effect is observed more clearly when the phenyl group is inhibited with a nitro group.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 16079-88-2. The above is the message from the blog manager. Application In Synthesis of 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 3543-73-5, Name is Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, formurla is C14H19N3O2. In a document, author is Tatsuma, T, introducing its new discovery. Recommanded Product: 3543-73-5.

Selective control of sensitivity to imidazole derivatives of interference-based biosensors by use of a phase transition gel

Sensitivity to histidine of an interference-based biosensor coated with a phase transition gel is controlled by swelling and shrinking the gel, while that to imidazole is not changed significantly.

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In an article, author is ENRIZ, RD, once mentioned the application of 3543-72-4, Name is Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate, molecular formula is C14H17N3O4, molecular weight is 291.3, MDL number is MFCD09840985, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Category: imidazoles-derivatives.

CALCULATION OF TAUTOMER PREFERENCE FOR RIGID IMIDAZOLE DERIVATIVES

The tautomeric preference of rigid imidazole derivatives has been analyzed theoretically from molecular orbital calculations ab initio. The present results indicate that the reduced potencies exhibited by imidazolylphenylene analogues of cimetidine and metiamide at the H2-receptor are consistent with those hypotheses that defined the N3-H tautomer of the monocation as the only recognizable species in this class of histamine H2-ligand. However, our results suggest that the 4-methylimidazolylphenylene analogue of cimetidine could be an effective histamine H3-antagonist.

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