Tag: M.W=200-300

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is STUPNISEKLISAC, E, once mentioned the application of 38668-46-1, Name is 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine, molecular formula is C9H13N7, molecular weight is 219.25, MDL number is MFCD00047350, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Name: 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine.

IMIDAZOLE DERIVATIVES AS CORROSION-INHIBITORS FOR ZINC IN HYDROCHLORIC-ACID

The efficiency of various imidazole derivatives as zinc corrosion inhibitors in hydrochloric acid (HCl) was investigated using electrochemical and gravimetric methods. A difference in efficiency (z) was observed with the introduction of different substituents into a imidazole skeleton. It was established that substituents which increased the electron density at the reaction center improved the corrosion inhibiting properties of the heterocyclic compound. A linear correlation between reaction kinetic data and the sum of the polar substituent constants was obtained.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 38668-46-1, Name: 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Name: Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate, 144689-94-1, Name is Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate, SMILES is O=C(C1=C(C(OCC)=O)NC(CCC)=N1)OCC, belongs to imidazoles-derivatives compound. In a document, author is Haddadzadeh, Elham, introduce the new discover.

One-pot Synthesize of Phenyl Phenanthro Imidazole Derivatives Catalyzed by Lewis Acid in the Presence of Ammonium Acetate

Tri substituted imidazole derivatives were synthesized with the combinations of phenanthroquinone, benzealdehyde derivatives at the presence of ammonium acetate that catalyzed by Lewis acid. In all reactions, polar solvent was used and the reactions were carried out under the reflux conditions. The structure of all compounds was confirmed using the IR and (HNMR)-H-1. This method revealed several advantages including, excellent yields, simplicity of operation and easy separation. The results showed that, products formed in high yields and low reaction times. Also, the metal atom of Lewis acid catalyst increased the reactivity of substrate and the reaction time. Copyright (C) 2020 by SPC (Sami Publishing Company)

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 144689-94-1 is helpful to your research. Name: Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate.

Related Products of 641571-11-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, SMILES is CC1=C[N](C=N1)C2=CC(=CC(=C2)N)C(F)(F)F, belongs to imidazoles-derivatives compound. In a article, author is EFIMENKO, IA, introduce new discover of the category.

SYNTHESIS AND STRUCTURE OF PALLADIUM(II) MIXED COMPLEXES WITH DNA PURINE OR PYRIMIDINE-BASES AND IMIDAZOLE DERIVATIVES .1.

Palladium(II) mixed ligand complexes with purine or pyrimidine and imidazole derivatives were prepared and characterized by i.r., Raman and electronic spectroscopy. The compounds have the general formula [Pd(L(1))(L(2))X(2))]; where L(1)=adenine, guanine, hypoxanthine, cytosine, 2-aminopyrimidine, 4(6)-hydroxypyrimidine; L(2) = N-methylimidazole, N-ethylimidazole or N-propylimidazole; X = Cl or Br. The complexes are square planar with cis-halogens. The purine, pyrimidine and imidazole bases act as monodentate ligands coordinated via the N(7) of purine and N(3) of pyrimidine and imidazole.

Related Products of 641571-11-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 641571-11-1.

Related Products of 16079-88-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 16079-88-2, Name is 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione, SMILES is O=C1N(Cl)C(C(C)(C)N1Br)=O, belongs to imidazoles-derivatives compound. In a article, author is Ramkumar, Sowmya, introduce new discover of the category.

Enhanced corrosion resistance of mild steel in sulphuric acid medium by imidazole derivative: Experimental and computational studies

The inhibition action of the imidazole derivative on the corrosion of mild steel in 0.5 M Sulphuric acid was investigated by weight loss, polarization, Impedance and SEM. The PZC of mild steel was studied by AC impedance method. The polarization experiment revealed that IDZ is of mixed-type but slightly anodic control. Weight loss results obtained revealed that the imidazoline derivatives performed excellently as corrosion inhibitor with efficiency above 70% at 20ppm at 303 K. The optimum period of inhibition for IDZ was determined by weight loss studies. Its adsorption on mild steel obeys Tempkin isotherm. Quantum chemical parameters and Mulliken charge densities on the optimized structure of imidazoline derivative were calculated using GAUSSIAN 09 with B3LYP / 6-31G (d,p) basis set. (C) 2019 Elsevier Ltd. All rights reserved.

Related Products of 16079-88-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 16079-88-2.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 38668-46-1, Name is 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine, SMILES is CC1=NC=CN1CCC2=NC(N)=NC(N)=N2, belongs to imidazoles-derivatives compound. In a document, author is Yuan, Ruijuan, introduce the new discover, COA of Formula: C9H13N7.

Synthesis of chiral SalenZn(II) and its coordination with imidazole derivatives and amino acid ester derivatives

A chiral complex, SalenZn(II) ( S), was synthesized and characterized. Its coordination with imidazole derivatives and amino acid ester derivatives was studied by UV-vis spectrophotometric titrations and CD spectroscopy. The binding constants decreased in the order K (Im)> K (2-MeIm)> K (2- Et-4-MeIm)> K (N-MeIm) for imidazole derivatives, and K (AlaOMe)> K (PheOMe)> K (ValOMe) for amino acid ester derivatives with the same configuration and K-D> K-L for amino acid esters with different configuration. CD spectra can quantify the strength of SalenZn(II)-ligand interactions, giving results consistent with the magnitudes of the binding constants. Moreover the minimum energy conformations of the adducts were obtained by simulated annealing, and quantum chemical calculations were performed based on those conformations to explain experimental results at the molecular level.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 38668-46-1 is helpful to your research. COA of Formula: C9H13N7.

Electric Literature of 3543-72-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 3543-72-4, Name is Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate, SMILES is O=C(OCC)CCCC1=NC2=CC([N+]([O-])=O)=CC=C2N1C, belongs to imidazoles-derivatives compound. In a article, author is Wang, Qianming, introduce new discover of the category.

Relationship Between the Structural Specialties and Morphologies Based on a Group of Luminescent Imidazole Derivatives with Sensing Properties

A group of low molecular weight imidazole derivatives have been prepared. They have two sensitive features including ultra-violet absorption and fluorescence spectra to detect fluoride anions. Particularly, compound 5 had a special side chain moiety effect in the assembly of microstructures. Regular and densely packed 1D morphologies can be found and easily formed in the presence of water and other conventional organic solvents.

Electric Literature of 3543-72-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 3543-72-4 is helpful to your research.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 38668-46-1, Name is 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine. In a document, author is Wang, Shu-Jun, introducing its new discovery. Category: imidazoles-derivatives.

Synthesis of a Series of Zinc Porphyrins and Spectroscopic Changes upon Coordination Reaction with Imidazole Derivatives

Three metal-free porphyrins modified with Boc-L-threonine and their zinc analogs were synthesized and characterized by elemental analysis, H-1 NMR, UV/vis, and fluorescence spectroscopies. The binding of imidazole derivatives to these zinc porphyrins was studied, with emphasis on the binding mechanism in CH2Cl2 solution, by means of UV/vis spectroscopy and quantum chemical methods. Both experimental results and theoretical calculations showed that a coordination reaction occurred between the zinc porphyrins and imidazole derivatives. The association constants between the zinc porphyrins and imidazole derivatives decreased in the order N-MeIm>Im. Increasing the temperature disfavored the interaction. Thermodynamic parameters calculated by the van’t Hoff equation showed that the driving force for the reaction was the enthalpy change. The fluorescence changes associated with the interaction between the zinc porphyrins and imidazole derivatives were also studied by fluorescence spectroscopy. The experimental results showed significant quenching between the various zinc porphyrins and imidazole derivatives.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 38668-46-1 help many people in the next few years. Category: imidazoles-derivatives.

Reference of 64591-03-3, These common heterocyclic compound, 64591-03-3, name is 2,5-Dibromo-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stuffed solution of 2,4-dibromothiazole (2) (4 mmol) in dimethylformamide (DMF) (15 mL), the coffesponding amine (1) (4 mmol) and diisopropylethylamine (DIPEA) (1.55 g, 2 mL, 12 mmol) were added under a stream of nitrogen.The reaction mixture was stirred at 80C for 4-10 h (monitored by Thin-layer chromatography (TLC)), then cooled to room temperature (rt), quenched with cold water (H20) (50 mL) and extracted with ethyl acetate (EtOAc) (3×30 mL). The combined organic layer was washed with H20 (2×10 mL), dried over sodium sulfate and concentrated to give the crude compound 3. The resulting product 3, the corresponding imidazole 4 (12 mmol),palladium(II)bis(triphenylphosphine) diacetate (Pd(OAc)2(PPh3)2) (0.1 mmol) and toluene (50 mL) were refluxed for 24 h. After cooling, the organic solvent was removed under vacuum. The resulting residue was purified by preparative high-performance liquid chromatography (HPLC) (EtOAc – Hexane (1:5) as eluent) to give the final product 5 as a solid. It was additionally purified by reverse phase HPLC (gradient acetonitrile (MeCN) – H20, 20 to 80% of MeCN aseluent). A compound of formula S are examples 1-15, 17-22, 24-40, 42-50 and 52-62.

The synthetic route of 64591-03-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; THE UNIVERSITY OF BRITISH COLUMBIA; BAN, Fuqiang; DALAL, Kush; FLOHR, Alexander; LEBLANC, Eric J. J.; LI, Huifang; RENNIE, Paul S.; TCHERKASSOV, Artem; (57 pag.)WO2018/114781; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 71759-87-0, These common heterocyclic compound, 71759-87-0, name is 4-Iodo-1-methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Procedure E3c – {3-r7-(1-Methyl-1 H-imidazol-4-yl)-imidazori ,2-alpyridin-3-yll-phenyl}-3-(2.2,2-trifluoro-ethyl)-urea; Procedure E3c is using the conditions described in generic Suzuki A4eTo a stirred mixture of 1-[3-(7-Boronic acid -imidazo[1 ,2-a]pyridn-3-yl)-phenyl]-3-(2,2,2- trifluoro-ethyl)-urea (0.15g, 0.39 mmol), in a MW tube was added 4-iodo-1-methyl-1 H- imidazole (83mg, 0.39mmol), SPHOS (6.5mg, 0.016mmol) and Pd2(dba)3 (7mg, 0.0076mmol ) in dioxane (2ml) followed by K3PO 4 (252mg, 1.18mmol) in water (1.2ml). The reaction mixture was heated in a CEM discover microwave synthesizer (300W) at 120 0C for hr. The mixture was allowed to cool, then partitioned between EtOAc /H2O, the organic layer was separated, dried (MgSO4), filtered and the solvent removed in vacuo. The residue was purified by prep HPLC to afford the desired product (8mg) MS: [M+H]+ = 415.To a stirred mixture of 1-[3-(7-Boronic acid -imidazo[1 ,2-a]pyridn-3-yl)-phenyl]-3-(2,2,2- trifluoro-ethyl)-urea (0.15g, 0.39 mmol), in a MW tube was added 4-iodo-1-methyl-1 H- imidazole (83mg, 0.39mmol), SPHOS (6.5mg, 0.016mmol) and Pd2(dba)3 (7mg, 0.0076mmol ) in dioxane (2ml) followed by K3PO 4 (252mg, 1.18mmol) in water (1.2ml). The reaction mixture was heated in a CEM discover microwave synthesizer (300W) at 120 0C for hr. The mixture was allowed to cool, then partitioned between EtOAc /H2O, the organic layer was separated, dried (MgSO4), filtered and the solvent removed in vacuo. The residue was purified by prep HPLC to afford the desired product (8mg) MS: [M+H]+ = 415.

Statistics shows that 4-Iodo-1-methyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 71759-87-0.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; WO2008/78091; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 28890-99-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28890-99-5 name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

a) 31.7 g (96.1 mmol) diiodobenzene, 14.9 g (72.1 mmol) 6H-benzimidazolo[1,2- a]benzimidazole, 23.5 g (72.1 mmol) cesium carbonate, 1.83 g (9.61 mmol) cupper (I) iodide, 2.21 g (19.3 mmol) L-proline in 400 ml DMSO was stirred under nitrogen at 100 C for3 h. The reaction mixture was poured in 600 ml water and the product was filtered off. The product is washed with water and ethanol. 100 ml diethyl ether is added and the mixture is stirred for 3 h. Product is filtered off and is washed with ether. To the product 200 ml dichloromethane is added and the mixture is refluxed for 2 h. The mixture is filtered and washed with dichloromethane. The solvent of the filtrate is distilled off. Colum chromatog10 raphy on silica gel with toluene/ethyl acetate 19/1 gave the product 6.47 g (22 %).1H NMR (400 MHz, DMSO-d6): = 8.32 (t, J =1.8 Hz, IH), 8.19-8.24 (m, 2H), 7.93-7.96 (m,IH) 7.86-7.88 (m, IH), 7.63-7.68 (m 2H), 7.38-7.49 (m, 3H), 7.28-7.36 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, and friends who are interested can also refer to it.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; STENGEL, Ilona; HEINEMEYER, Ute; NAGASHIMA, Hideaki; BARDON, Kristina; WO2015/150234; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem