Tag: M.W=200-300

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 71759-87-0, name is 4-Iodo-1-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Computed Properties of C4H5IN2

To a solution of 2-benzyloxy-5-(4,4, 5,5-tetramethyl-[i , 3,2]dioxaborolan-2-yl)benzamide (Preparation 162, 5 g, i4.i6 mmol) and 4-iodo-i-methyl-iH-imidazole (2.94 g, i4.i6 mmol) in DMF (60 mL) was added a solution of potassium carbonate (4.89 g, 35.4i mmol) in water (iO mL). The solution was degassed with argon for i5 minutes followed by the addition of iibis(diphenylphosphino)ferrocene palladium (II) dichloride (578 mg, 0.7i mmol). The reactionwas heated to iioC for i6 hours before cooling and diluting with EtOAc (300 mL). The organic solution was washed with water (2 x iOO mL), brine (75 mL), dried over sodium sulphate and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with 0-4% MeOH in DCM to afford the title compound (i g, 23%).1H NMR (400 MHz, DMSO-d6): O ppm 3.66 (5, 3H), 5.25 (5, 2H), 7.20 (d, iH), 7.34 (t, iH), 7.4i(t, 2H), 7.50-7.54 (m, 4H), 7.59-7.6i (m, 2H), 7.77 (dd, iH), 8.i5 (d, iH). MS mlz 308 [M+H]

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PFIZER LIMITED; SKERRATT, Sarah Elizabeth; BAGAL, Sharanjeet Kaur; SWAIN, Nigel Alan; OMOTO, Kiyoyuki; ANDREWS, Mark David; WO2015/92610; (2015); A1;,
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Imidazole | C3H4N2 – PubChem

Reference of 28890-99-5, These common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1 a) 20 g (96.5 mmol) 6H-benzimidazolo[1 ,2-a]benzimidazole is dissolved in 400 ml trifluoro- acetic acid under nitrogen. 43.4 g (193 mmol) N-lodosuccinimide is added in 10 minutes. The reaction mixture is stirred at 25 C for 24 h under nitrogen. The precipitated product is filtered off and crystalized from trifluoroacetic acid (yield: 19.2 g (43 %)). 1 H NMR (400 MHz, TFA-d1): delta 8.77-8-78 (m, 2H), 8.34-8.37 (m, 2H), 7.91-7.94 (m, 1 H).

The synthetic route of 28890-99-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO., LTD (IKC); SCHAeFER, Thomas; RAIMANN, Thomas; NAGASHIMA, Hideaki; (108 pag.)WO2016/16791; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 53484-16-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53484-16-5, name is 6-Bromo-1-methyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of Pd2(dba)3 (0.01 mmol) and Xantphos (0.01 mmol) in 1,4-dioxane (1 mL) was sonicated and added under nitrogen to a mixture of 6-bromo-1-methyl-benzimidazole (0.45 mmol), 2,3-dihydro-1,4-benzodioxin-6-amine (0.58 mmol) and Cs2CO3 (0.62 mmol) in 1,4-dioxane (2 mL). The mixture was stirred at 110¡ã C. for 12 h. The mixture was diluted (DCM), washed (H2O), dried (phase separator and concentrated. The residue was purified by prep HPLC to yield the desired product (Compound B). [0542] MW: 281.3. MS Ms?d: 282.1. [0543] NMR: 1H NMR (400 MHz, DMSO-d6): delta=7.94 (1H, s), 7.80 (1H, br s), 7.45 (1H, d), 7.05 (1H, d), 6.86 (1H, dd), 6.73 (1H, dd), 6.61-6.57 (2H, m), 4.22-4.16 (4H, m), 3.71 (3H, s).

The chemical industry reduces the impact on the environment during synthesis 6-Bromo-1-methyl-1H-benzo[d]imidazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MENET, Christel Jeanne Marie; MAMMOLITI, Oscar; BLANC, Javier; ORSULIC, Mislav; ROSCIC, Maja; US2015/203455; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 641571-13-3,Some common heterocyclic compound, 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, molecular formula is C12H9F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of the carboxylic acid 6m (1.0g, 3.91 mmol) in DMF (18mL), HOBt (0.59g, 4.69 mmol) and EDC (0.82mL, 4.69 mmol) was added 4-methyl-3-nitroaniline (0.71 g, 4.69 mmol) and the mixture was stirred at 25 C for 12 hours. The reaction mixture was concentrated under reduced pressure, redissolved in EtOAc and extracted with 0.5 M NaHCO3 and water. The organic phase was dried over MgSO4, concentrated under reduced pressure and the resulting solid was washed with DCM and hexane affording the desired amide in pure form (1.01g, 64% yield). IR (neat): upsilon? = 3344, 1682, 1654, 1603, 1537, 1524, 1498, 1448, 1407, 1305, 1283, 1255, 1172, 1121, 1103, 1079, 1001, 904, 877, 829, 812, 751, 739, 690, 671, 617, 503, 418 cm-1; MS (ESI), m/z: calcd for C19H16F3N4O3+, 405.11690; found, 405.11716.

The synthetic route of 641571-13-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Universitaet Zuerich; Unzue Lopez, Andrea; Dong, Jing; Lafleur, Karine Anne; Zhao, Hongtao; Frugier, Emilie; Caflisch, Amedeo; Nevado Blazquez, Cristina; EP2924039; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10351-75-4, name is 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 1H-Benzo[d]imidazole-5,6-dicarboxylic acid

A mixture of H3bidc (0.0824g, 0.4mmol), InCl3¡¤4H2O (0.2ml, 0.1M) was added to CH3CN (4ml), HNO3 (0.4ml, 1M) and H2O (1ml) in a 23ml Teflon-lined autoclave and then heated under autogenous pressure at 120C for 24h, then cooled to room temperature under ambient conditions. Colorless block crystals were obtained by filtration and washed with distilled water, and dried in air. Yield: 85% for 1 (based on InCl3¡¤4H2O). Elemental analysis (%) for 1: Anal. Calc. C, 37.47; H, 1.73; N, 9.71; Found: C, 37.35; H, 1.55; N, 9.78. IR (KBr pellet, cm-1) for 1 (4000-400cm-1): 3254 (s), 1594 (s), 1384 (s), 1329 (s), 1035 (m), 1235 (m), 921 (w), 847 (w), 786 (s), 639 (m), 500 (m) (Fig. S5).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Chai, Juan; Wang, Pengcheng; Jia, Jia; Ma, Bing; Sun, Jing; Tao, Yufang; Zhang, Ping; Wang, Li; Fan, Yong; Polyhedron; vol. 141; (2018); p. 369 – 376;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24155-42-8, name is 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol, A new synthetic method of this compound is introduced below., Recommanded Product: 24155-42-8

(b) 5-Bromo-4-[[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy]methyl]-2-methylthiazole, hydrochloride (1:1) Following the procedure of Example 1b, reaction of 5-bromo-4-chloromethyl-2-methylthiazole and 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol, yields the title compound, m.p. 247-248 C. (absolute ethanol).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4307105; (1981); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10351-75-4, name is 1H-Benzo[d]imidazole-5,6-dicarboxylic acid, A new synthetic method of this compound is introduced below., Formula: C9H6N2O4

2.2.2 H23-DPBB The above mentioned synthesis procedure was repeated except 3-aminobenzoic acid was used. Yield: 65.5%. Element analysis (%): Anal. Calc. C16H9N3O4: C 62.54, H 2.95, N 13.68. Found: C 62.60, H 2.92, N 13.69%. IR (KBr pellet, cm-1): 3310(m), 2520(m), 1780(vs), 1670(vs), 1600(m), 1550(m), 1480(vs), 1090(vs), 840(m), 776(m), 673(s), 543(s). Negative ESI-MS (m/z): 305.88 (H23-DPBB-H+). 1H NMR (DMSO-d6): delta: 7.669 (J = 1.6 Hz, t, 1H, Ph-H), 7.747 (J = 7.2 Hz, d, 1H, Ph-H), 7.995 (J = 8.0 Hz, d, 1H, Ph-H) 8.057 (s,1H, Ph-H) 8.104 (s, 1H, Ph-H) 8.201 (s, 1H, Ph-H), 8.596 (s, 1H, Im-H), 13.293 (s, 1H, COOH). Melting points: above 300 C.

The synthetic route of 10351-75-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Jing-Si; Zhu, Jiang; Liu, Rui-Bin; Ni, Jun; Chang, Zhi-Duo; Hu, Tao; Zhang, Jian-Jun; Meng, Chang-Gong; Inorganica Chimica Acta; vol. 394; (2013); p. 117 – 126;,
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Imidazole | C3H4N2 – PubChem

Related Products of 37067-95-1, A common heterocyclic compound, 37067-95-1, name is 2-Iodo-1-methyl-1H-imidazole, molecular formula is C4H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

b) Synthesis of N1-methyl-N1-(1-methyl-1H-imidazol-2-yl)ethane-1,2-diamine A mixture of 4.8 g (23.0 mmol) 2-iodine-1-methyl-imidazol, 12.2 ml (138.0 mmol) N-methyl-ethylene-diamine, 80 mg (1.3 mmol) copper and 374 mg (3.8 mmol) copper(I) chloride was heated for 1 h to 70 C. erhitzt. After cooling to RT, the solution was received with brine and DCM and the phases were separated. The organic phase was dried over MgSO4, filtered and concentrated in a vacuum. CC (DCE/EtOH/conc. aq. NH4OH sol. 5:1:0.06) was performed with the residue, whereby 215 mg (1.4 mmol, 6%) N1-methyl-N1-(1-methyl-1H-imidazol-2-yl)ethane-1,2-diamine was obtained.

The synthetic route of 37067-95-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Grunenthal GmbH; US2008/261996; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33529-02-1, name is 1-Decyl-1H-imidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Decyl-1H-imidazole

In a necked 50 ml equipped with acondenser, 4.9 ml (57 mmol) of allyl bromide areadded dropwise to 0.01 mol of 1a(2.92g) or 1b(2.08g) in room temperature and free solventconditions. The reaction mixture is refluxed andstirred until a solid slightly pasty appears. Thisresidue is triturated with ether and then filteredunder vacuum to obtain a solid dough.

The synthetic route of 33529-02-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Djellal, Ahmed; Amirat, Samia; Oriental Journal of Chemistry; vol. 31; 4; (2015); p. 2391 – 2394;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 24155-42-8,Some common heterocyclic compound, 24155-42-8, name is 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol, molecular formula is C11H10Cl2N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1: R- (-) -1- (2,4-dichlorophenyl) -2- (lH-imidazol-1- yl) -ethanol (VI); To a solution of 5 g of 1- (2, 4-dichlorophenyl) -2- (IH- imidazol-1-yl) -ethanol (II) in a mixture of acetone- methanol, 3.21 g of D-tartaric acid dissolved in a mixture of acetone-methanol were added at room temperature. Once the addition was completed, the mixture was stirred for further 30 minutes at room temperature. The resultant solid was filtered and crystallized from methanol. A mixture consisting of the resulting salt, water and methylene chloride was treated with a concentrated solution of sodium hydroxide. The organic layer was washed with water and concentrated at reduced pressure to yield 1.85 g (37%) of (VI) whose enantiomeric purity was higher than 98% in R- {-) isomer.

The synthetic route of 24155-42-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FERRER INTERNACIONAL, S.A.; WO2006/29811; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem