Tag: M.W=250-300

Weerakkody, Chandima published the artcileEnhanced Catalytic Properties of Molybdenum Promoted Mesoporous Cobalt Oxide: Structure-Surface-Dependent Activity for Selective Synthesis of 2-Substituted Benzimidazoles, Name: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is ChemCatChem (2019), 11(1), 528-537, database is CAplus.

High-valent molybdenum ions were substituted into the cobalt oxide lattice through a one step, sol-gel method and investigated for selective synthesis of 2-substituted benzimidazoles. Catalyst synthesis involves surfactant assisted soft templating inverse micelle method, which forms mesopores by interconnected intraparticle voids. Substitutional doping of Mo⁶⁺ resulted in materials with modified structural, morphol., surface, and redox properties. The catalytic activity increased with Mo concentration until an optimum amount (3 % Mo incorporation). Modified material shows lattice expansion, increased surface oxygen vacancies, and high surface area, which are responsible for the higher catalytic activity in selective benzimidazole synthesis reaction. A strong correlation between surface properties of the catalyst and the product selectivity was observed and plausible mechanistic and kinetic data are proposed and collected, resp.

ChemCatChem published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C5H6N2O2, Name: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kumar, Manoranjan published the artcileIron(III) Chloride-Catalyzed Decarboxylative-Deaminative Functionalization of Phenylglycine: A Tandem Synthesis of Quinazolinones and Benzimidazoles, Quality Control of 2622-67-5, the publication is Advanced Synthesis & Catalysis (2015), 357(13), 2862-2868, database is CAplus.

The first iron(III) chloride-catalyzed decarboxylative-deaminative functionalization of phenylglycine with o-substituted nitroarenes was achieved for the synthesis of 4(3H)-quinazolinones and benzimidazoles. The reaction of 2-nitrobenzonitrile/2-nitro-N,N-diphenylamine with phenylglycine at 120 C in the presence of potassium carbonate as a base in toluene generated the products in 45-87% yields. Various functional groups like nitro, fluoride, chloride and trifluoromethyl were well tolerated under the present reaction conditions. In this tandem approach, involvement of transfer hydrogenation of the nitro functionality with in situ generated ammonia, imination, nitrile hydration to amide and oxidative cyclization sequences have been established. The process avoids the use of an external hydrogen source, costly catalysts as well as the isolation of amine and amide intermediates.

Advanced Synthesis & Catalysis published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Quality Control of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Keni, Shubham published the artcileBenzimidazole: a propitious scaffold with multifarious therapeutic potential, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is European Journal of Biomedical and Pharmaceutical Sciences (2018), 5(11), 483-488, database is CAplus.

A review is presented on the antibacterial, antifungal, antiviral, antiinflammatory, antihypertensive activity of benzimidazole derivatives as drug. Most of the drugs and pharmacol. active moieties possess heterocyclic ring structure and presence of hetero atoms or groupings evinces privileged specificities in their pharmacol. targets. Among the heterocyclic compounds, benzimidazole has emerged as cardinal construction motif, which plays pivotal role in drug development. Benzimidazole scaffold is known to possess some prime pharmacol. activities like anti- mycobacterial, antimicrobial, anti-viral, antioxidant, antiinflammatory, antihypertensive, etc. This broad spectrum of biol. and biochem. activities was further assisted by the synthetic flexibility of benzimidazole, which permits development of large no of structurally diverse derivatives Therefore, it is necessary to compile the latest information along with earlier information to understand present status of benzimidazole nucleus in drug discovery. In the present review, various derivatives of benzimidazole possessing anti-mycobacterial, antimicrobial, analgesic and antiinflammatory potential are brought into limelight and their activity was elucidated in accordance with structure activity relation studies.

European Journal of Biomedical and Pharmaceutical Sciences published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jeyachandran, Rajkumar published the artcileCopper-catalyzed CuAAC/intramolecular C-H arylation sequence: synthesis of annulated 1,2,3-triazoles, Application of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Beilstein Journal of Organic Chemistry (2012), 1771-1777, database is CAplus and MEDLINE.

Step-economical syntheses of annulated 1,2,3-triazoles, e.g., I, were accomplished through copper-catalyzed intramol. direct arylations in sustainable one-pot reactions. Thus, catalyzed cascade reactions involving [3 + 2]-azide-alkyne cycloadditions (CuAAC) and C-H bond functionalizations provided direct access to fully substituted 1,2,3-triazoles with excellent chemo- and regio-selectivities. Likewise, the optimized catalytic system proved applicable to the direct preparation of 1,2-diarylated azoles through a one-pot C-H/N-H arylation reaction.

Beilstein Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Application of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Ruipu published the artcileOxidative Synthesis of Benzimidazoles, Quinoxalines, and Benzoxazoles from Primary Amines by ortho-Quinone Catalysis, Computed Properties of 2622-67-5, the publication is Organic Letters (2017), 19(20), 5629-5632, database is CAplus and MEDLINE.

The bioinspired ortho-quinone catalysts have been applied to heterocycles synthesis. Without any metal cocatalysts, a sole ortho-quinone catalyst enables the oxidative synthesis of benzimidazoles, quinoxalines and benzoxazoles from primary amines in high yields under mild conditions with oxygen as the terminal oxidant.

Organic Letters published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C9H20Cl2Si, Computed Properties of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Bing published the artcileElectrocatalytic water-splitting for the controllable and sustainable synthesis of deuterated chemicals, Application In Synthesis of 2622-67-5, the publication is Science Bulletin (2021), 66(6), 562-569, database is CAplus.

Tandem water electrolysis for the transformation of universal feedstock to value-added chems. integrated with hydrogen generation and in situ utilization is a promising approach to address the economic challenges of electrochem. hydrogen evolution and storage. Herein, we present the controllable electrocatalytic deuteration of halides using inexpensive and reusable heavy water (D₂O) as a D-source for the preparation of valuable D-labeled chems. and pharmaceuticals under mild conditions. This electrochem. deuteration method with high efficiency and selectivity furnishes a series of D-labeled chems. and pharmaceuticals in high yields with excellent D-incorporation. The reaction efficiency and selectivity, i.e., the precise substitution of deuterium atoms at different halogen positions, can be tuned by varying the applied voltages. The results show the great potential of green and economical electrocatalytic methods for producing value-added fine chems. in addition to hydrogen evolution.

Science Bulletin published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C7H13BrSi, Application In Synthesis of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Subramanian, Saravanan published the artcileSustainable Nanoporous Benzoxazole Networks as Metal-Free Catalysts for One-Pot Oxidative Self-Coupling of Amines by Air Oxygen, Application of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Advanced Sustainable Systems (2017), 1(10), 1-7, database is CAplus.

Here, an efficient, nanoporous, heterogeneous benzoxazole catalyst is reported for aerobic oxidative coupling of amines. A mol. design strategy is presented to functionalize primary amines to produce valuable products under one-pot, open-air reaction conditions. Unprecedented and previously unknown, the stable imine intermediate catalyzes its own formation, also known as autocatalysis, enabling a direct and favorable access to amino acids, even if the catalysts are absent. The biomimetic benzoxazole catalysts developed here provide quant. catalytic activity over 50 cycles with favorable kinetics with no degradation This work also marks the first use of benzoxazoles for oxidative catalytic reactions.

Advanced Sustainable Systems published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C17H37NO3, Application of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Xiong, Wu-Lin published the artcileConstruction of a Clock Catalytic System: Highly Efficient and Self-Indicating Synthesis of Benzoheterocycles at Ambient Temperature, Category: imidazoles-derivatives, the publication is Asian Journal of Organic Chemistry (2021), 10(12), 3321-3327, database is CAplus.

Inspired by the mechanism of the clock reaction, a novel phosphomolybdenum blue (PMB) clock catalytic system was constructed for a highly efficient synthesis of benzimidazoles and benzothiazoles simply at ambient temperature The PMB clock catalytic system exhibited a sharp decoloration event to announce the depletion of the intermediate constraint, making this synthetic approach self-indicating and TLC-free. XPS and ³¹P NMR anal. of PMB catalyst showed that only two Mo⁶⁺ atoms were reduced to Mo⁵⁺ atoms in the Keggin structure due to the moderate reducibility of benzimidazoline and benzothiazoline intermediates. Thus,the active Keggin-type POM cluster could be well maintained in DMSO during the redox cycling of phosphomolybdic acid (PMA) and PMB. The ¹H NMR tracing experiment not only confirmed the proposed reaction mechanism but also showed that PMB exerts Lewis acid catalytic activity at the early phase of the reaction other than the expected redox catalytic activity.

Asian Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C18H12ClNO, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Berezin, Andrey A. published the artcileRing contraction of 1,3-diphenylbenzo[1,2,4]triazinyl radicals to 1,2-diphenylbenzimidazoles, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Organic & Biomolecular Chemistry (2014), 12(10), 1641-1648, database is CAplus and MEDLINE.

Reductive ring contraction of 1,3-diphenyl-1,4-dihydrobenzo[e][1,2,4]triazin-4-yls (Blatter’s radicals) I (R = H, Cl, Br, I, CF₃, Ph, 2-furyl) using zinc powder (2 equivalent) in acetic acid heated to ca. 118 °C gives 1,2-diphenylbenzimidazoles II in high yield. 1,3-Diphenylbenzo[e][1,2,4]triazin-7(1H)-one and the zwitterionic tetraphenylhexaazaanthracene (TPHA) also undergo reductive ring contractions to give 1,2-diphenylbenzimidaz-6-ol and 1,2,6,7-tetraphenyl-1,7-dihydrobenzo[1,2-d:4,5-d’]diimidazole, resp. By using less zinc, the incomplete reduction of TPHA gave the stable organic radical 1,3,7,8-tetraphenyl-4,8-dihydro-1H-imidazo[4,5-g][1,2,4]benzotriazin-1-yl. Imidazolo-, oxazolo- and thiazolo-fused 1,2,4-benzotriazinyls all undergo zinc mediated ring contractions to give imidazolo-, oxazolo- and thiazolo-fused benzimidazoles in excellent yields.

Organic & Biomolecular Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jayabharathi, J. published the artcileBenzimidazole based Ir(III) picolinate complexes as emitting materials and the fluorescent behavior of benzimidazole bound to Mn-TiO₂@ZnO core/shell nanospheres, Related Products of imidazoles-derivatives, the publication is Materials Express (2014), 4(4), 279-292, database is CAplus.

Photophys. and electroluminescent studies of cyclometalated heteroleptic iridium(III) complexes have been carried out. The strongly allowed phosphorescence in these picolinate complexes is the result of significant spin-orbit coupling of the iridium center. The lowest energy of these picolinate complexes corresponds to a mixture of metal to ligand charge transfer (MLCT) and π-π* states. Weak bands located at longer wavelength are due to the ¹MLCT ← S₀ and ³MLCT ← S₀ transitions of iridium complexes. Devices show better performance in terms of brightness and moderate power and current efficiencies. Absorption, fluorescence and lifetime spectral studies have been made to probe the interaction of 2-(4-trifluoromethylphenyl)-1-phenyl-1H-benzo[d]imidazole (TFMPPB) with sol-gel synthesized Mn-doped TiO₂@ZnO core/shell, pristine ZnO and Mn-doped TiO₂ nanoparticles. The emission of TFMPPB is enhanced by Mn-doped TiO₂@ZnO core/shell, pristine ZnO and Mn-doped TiO₂ nanoparticles which are likely due to lowering of LUMO and HOMO levels of the benzimidazole. Electron injection from photoexcited TFMPPB to the Mn-TiO₂@ZnO CB(S* → S⁺ + e^–_CB) is likely to the reason for the fluorescence enhancement.

Materials Express published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem