Tag: M.W=300-400

HPLC of Formula: 16961-25-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about Engineered targeted hyaluronic acid-glutathione-stabilized gold nanoclusters/graphene oxide-5-fluorouracil as a smart theranostic platform for stimulus-controlled fluorescence imaging-assisted synergetic chemo/phototherapy. Author is Yang, Ying; Wang, Shuxin; Wang, Chen; Tian, Chen; Shen, Yuhua; Zhu, Manzhou.

A theranostic platform with integrated diagnostic and therapeutic functions as well as specific targeted and controlled combination therapy to enhance treatment efficacy is of great importance for a wide range of biomedical applications. Here, we first attempted to develop biocompatible hyaluronic acid (HA)-glutathione (GSH) conjugate stabilized gold nanoclusters (GNCs) combined with graphene oxide (GO), accompanied by loading 5-fluorouracil (5FU), as a novel theranostic platform (HG-GNCs/GO-5FU, HG refers to HA-GSH). Multifunctional HG-GNCs possessed excellent fluorescence, photosensitivity and specific targeting ability to the cancer cells while their fluorescence and singlet oxygen generation could be strongly inhibited by GO and then effectively restored by lysosomal hyaluronidase in tumor cells. The sustained and complete release of 5FU from HG-GNCs/GO could also be stimulated successively by enzymic degradation of HA and light-induced heat effect of GO under laser irradiation so that turn-on cell imaging-assisted synergistic therapeutic strategies associated with triple enzyme/light-controlled chemo/photothermal/photodynamic therapy could be achieved at the same time, reducing greatly the side effects of materials to normal cells. Our study presents a novel strategy to combine targeting and bioimaging with triple therapies to enhance the antitumor effect.

In addition to the literature in the link below, there is a lot of literature about this compound(Hydrogen tetrachloroaurate(III) trihydrate)HPLC of Formula: 16961-25-4, illustrating the importance and wide applicability of this compound(16961-25-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3229-00-3, is researched, SMILESS is BrCC(CBr)(CBr)CBr, Molecular C5H8Br4Journal, Procedia Engineering called The synthesis of pentaerythrityl tetrakis[imidazole], Author is Liu, Haiyan; Gu, Da Ming; Liu, Guoyu; Zhao, Xiuli; Chen, Cheng, the main research direction is pentaerythritol imidazole preparation.Safety of Pentaerythrityltetrabromide.

A method for the preparation of pentaerythrityl tetrakis[imidazole] was reported and the synthesis of the target compound was achieved using pentaerythritol and imidazole as starting material, formation of pentaerythrityl tetrabromide(PEBr4) and reaction with imidazole. The overall yield was 68.6%. The product thus obtained [i.e., 1,1′-[2,2-bis(1H-imidazol-1-ylmethyl)-1,3-propanediyl]bis[1H-imidazole] [tetrakis(imidazol-1-ylmethyl)methane]] was confirmed by 1H-NMR, 13C-NMR.

This literature about this compound(3229-00-3)Safety of Pentaerythrityltetrabromidehas given us a lot of inspiration, and I hope that the research on this compound(Pentaerythrityltetrabromide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Eutectic solidification of the quasi binary system of isotactic polypropylene and pentaerythrityl tetrabromide, published in 1977, which mentions a compound: 3229-00-3, mainly applied to eutectic solidification polypropylene pentaerythrityl bromide, Product Details of 3229-00-3.

The title eutectic solidification was studied to gain some understanding of the simultaneous crystallization of a polymer and a diluent with a metal-like character. Pentaerythrityl tetrabromide (I) [3229-00-3] had a melting range of 157-9°, appropriate for the occurrence of a eutectic point. Despite the fact that the value of α = 6 of I was rather high, in polymer solutions I produced dendrites upon solidification, typical of metallic behavior, and I was classified as pseudodendritic. Considering the metal-like habit of both components, it was expected that the eutectic solidification process would proceed in a cooperative way, forming regular structures which should depend on the growth rate. In controlled solidification of the I-isotactic polypropylene (II) [25085-53-4] eutectic, coupled growth of the I and II mols. was observed at growth rates <3 mm/h. The formed eutectic microstructure consisted of I rods dispersed in a II matrix. The lateral dimension of these rods depended on the rate of solidification and ranged from 0.3 to 1.0 μm. At growth rates <3 mm/h, uncoupled growth of I and II was observed, producing a structure of randomly mixed II spherulites and I crystals. In the solidification of off-eutectic solutions with an excess of I, a remarkable nucleating effect of the primary I crystals was found. This indicated the importance of eutectics in polymeric systems, which could be applied in dispersing crystalline additives such as nucleating agents or in the in situ production of polymer composites. Also, solidification of eutectic polymer-diluent systems provided a method for producing porous materials by removal of the small mol. compound, where the lateral dimensions of the pores depended on the growth rate. This literature about this compound(3229-00-3)Product Details of 3229-00-3has given us a lot of inspiration, and I hope that the research on this compound(Pentaerythrityltetrabromide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Dynamic metallization of spherical DNA via conformational transition into gold nanostructures with controlled sizes and shapes, published in 2021-07-15, which mentions a compound: 16961-25-4, mainly applied to gold nanostructure dynamic metalization conformational transition ionic strength; Au; Catalysis; Conformation transition; DNA template; Dynamic metallization; Surface-enhanced Raman spectroscopy, Computed Properties of AuCl4H7O3.

Despite the reversible condensation properties of DNA, DNA metalization during controlled conformational transitions has been rarely investigated. We perform dynamic metalization of spherically condensed DNA nanoparticles (DNA NPs) via a globule-to-coil transition. A pos. charged new Au3+ reagent is prepared via ligand-exchange of conventional complex Au3+ ions, which was used to synthesize spherically condensed DNA NPs simply based on the fundamental electrostatic and coordinative interactions between DNA and Au3+ ions. Interestingly, the size of the Au3+-condensed DNA NPs (Au3+-DNA NPs) and the type of reducing agents lead to the formation of different Au nanostructures with unprecedented morphologies (cracked NPs, bowl-shaped NPs, and small NPs), owing to the controlled conformational changes in the Au3+-DNA NPs during metalization. The condensed DNA NPs play significant roles for Au nanostructures as (1) the dynamic template for the synthesis, (2) the reservoir and supply of Au3+ for the growth, and (3) the surface stabilizer. The synthesized Au nanostructures are remarkably stable against high ionic strength and exhibit catalytic activities and excellent SERS properties. This is the first study on the morphol. control and concomitant dynamic metalization of spherically condensed DNA, proposing new synthetic routes for bioinorganic nanomaterials.

This literature about this compound(16961-25-4)Computed Properties of AuCl4H7O3has given us a lot of inspiration, and I hope that the research on this compound(Hydrogen tetrachloroaurate(III) trihydrate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quality Control of Tricyclohexylphosphonium tetrafluoroborate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Tricyclohexylphosphonium tetrafluoroborate, is researched, Molecular C18H34BF4P, CAS is 58656-04-5, about Evaluating the photovoltaic properties of two conjugated polymers synthesized by Suzuki polycondensation and direct C-H activation.

Two conjugated polymers HXS-1 and PDFCDTBT were prepared by direct C-H activation and Suzuki polycondensation and their chem. structures were characterized by 1H NMR spectroscopy. The mol. weight of conjugated polymer synthesized by direct C-H activation is lower than the corresponding polymers prepared by Suzuki polycondensation. Conjugated polymers synthesized by direct C-H activation have considerable solubility in common organic solvents and form amorphous film. The photovoltaic property of conjugated polymers synthesized by direct C-H activation is inferior to the corresponding polymers synthesized by Suzuki polycondensation.

This literature about this compound(58656-04-5)Quality Control of Tricyclohexylphosphonium tetrafluoroboratehas given us a lot of inspiration, and I hope that the research on this compound(Tricyclohexylphosphonium tetrafluoroborate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mahmoud, Nouf N.; Abu-Dahab, Rana; Hamadneh, Lama A.; Abuarqoub, Duaa; Jafar, Hanan; Khalil, Enam A. published an article about the compound: Hydrogen tetrachloroaurate(III) trihydrate( cas:16961-25-4,SMILESS:Cl[Au-](Cl)(Cl)Cl.[H]O[H].[H]O[H].[H]O[H].[H+] ).Product Details of 16961-25-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:16961-25-4) through the article.

Gold nanorods (GNRs) have gained pronounced recognition in the diagnosis and treatment of cancers driven by their distinctive properties. Herein, a gold-based nanosystem was prepared by utilizing a phospholipid moiety linked to thiolated polyethylene glycol, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-PEG-SH, as a surface decorating agent. The synthesized phospholipid-PEG-GNRs displayed good colloidal stability upon exposure to the tissue culture medium. Cytotoxicity of phospholipid-PEG-GNRs was investigated toward MCF-7 and T47D breast cancer cells using sulforhodamine B test. The results revealed that phospholipid-PEG-GNRs demonstrated high cytotoxicity to MCF-7 cells compared to T47D cells, and minimal cytotoxicity to human dermal fibroblasts. The cellular uptake studies performed by imaging and quant. anal. demonstrated massive internalization of phospholipid-coated GNRs into MCF-7 cells in comparison to T47D cells. The cellular death modality of cancer cells after treatment with phospholipid-PEG-GNRs was evaluated using mitochondrial membrane potential assay (JC-1 dye), gene expression anal., and flow cytometry study. The overall results suggest that phospholipid-modified GNRs enhanced mainly the cellular apoptotic events in MCF-7 cells in addition to necrosis, whereas cellular necrosis and suppression of cellular invasion contributed to the cellular death modality in the T47D cell line upon treatment with phospholipid-PEG-GNRs. The phospholipid-coated GNRs interact in a different manner with breast cancer cell lines and could be considered for breast cancer treatment.

In addition to the literature in the link below, there is a lot of literature about this compound(Hydrogen tetrachloroaurate(III) trihydrate)Product Details of 16961-25-4, illustrating the importance and wide applicability of this compound(16961-25-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Safety of Hydrogen tetrachloroaurate(III) trihydrate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro. Author is Wahab, Rizwan; Kaushik, Neha; Khan, Farheen; Kaushik, Nagendra Kumar; Lee, Su-Jae; Choi, Eun Ha; Al-Khedhairy, Abdulaziz A..

Over the past several decades, the incidence of solid cancers has rapidly increased worldwide. Successful removal of tumor-initiating cells within tumors is essential in the field of cancer therapeutics to improve patient disease-free survival rates. The biocompatible multivarient-sized gold nanoparticles (MVS-GNPs) from quantum dots (QDs, <10 nm) to nanosized (up to 50 nm) particles have vast applications in various biomedical areas including cancer treatment. The role of MVS-GNPs for inhibition of tumorigenic potential and stemness of glioma was investigated in this study. Herein, MVS-GNPs synthesized and characterized by means of X-ray diffraction pattern (XRD) and transmission electron microscopy (TEM) techniques. Afterwards, interaction of these GNPs with glioma stem-cell like cells along with cancer cells were evaluated by MTT, cell motility, self-renewal assays and biostatistics was also applied. Among these GNPs, G-QDs contributed to reduce metastatic events and spheroid cell growth, potentially blocking the self-renewal ability of these cells. This study also uncovers the previously unknown role of the inhibition of CTNNB1 signaling as a novel candidate to decrease the tumorigenesis of glioma spheroids and subsequent spheroid growth. The accurate and precise biostatistics results were obtained at quantify level. In summary, G-QDs may exhibit possible contribution on suppressing the growth of tumor-initiating cells. These data reveal a unique therapeutic approach for the elimination of residual resistant stem-like cells during cancer treatment. In addition to the literature in the link below, there is a lot of literature about this compound(Hydrogen tetrachloroaurate(III) trihydrate)Safety of Hydrogen tetrachloroaurate(III) trihydrate, illustrating the importance and wide applicability of this compound(16961-25-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 58656-04-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Tricyclohexylphosphonium tetrafluoroborate, is researched, Molecular C18H34BF4P, CAS is 58656-04-5, about Synthesis of Lapatinib via direct regioselective arylation of furfural. Author is Erickson, Greg; Guo, Jiasheng; McClure, Mike; Mitchell, Mark; Salaun, Marie-Catherine; Whitehead, Andrew.

A new synthesis of Lapatinib I, an orally active drug for breast cancer, is described. The synthesis involves a palladium catalyzed regioselective arylation of furfural with 6-bromo-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine. This key step replaces an atom inefficient Suzuki cross coupling reaction used in a previously disclosed route and significantly shortens the synthesis.

In addition to the literature in the link below, there is a lot of literature about this compound(Tricyclohexylphosphonium tetrafluoroborate)Application of 58656-04-5, illustrating the importance and wide applicability of this compound(58656-04-5).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Predictable and Site-Selective Functionalization of Poly(hetero)arene Compounds by Palladium Catalysis, published in 2011-02-04, which mentions a compound: 58656-04-5, mainly applied to arene heteroarene regioselective arylation palladium catalyst reactivity, Computed Properties of C18H34BF4P.

The challenge of achieving selective and predictable functionalizations at C-H bonds with complex poly(hetero)aromatic substrates was addressed by two different approaches. Site-selectivity can be obtained by applying various reaction conditions that are (hetero)arene specific to substrates that contain indoles, pyridine N-oxide, and polyfluorinated benzenes. An exptl. classification of electron-rich heteroarenes based on their reactivity toward palladium-catalyzed C-H functionalization was established, the result of which correlated well with the order of reactivity predicted by the DFT-calculated concerted metalation-deprotonation (CMD) pathway. Model substrates containing two reactive heteroarenes were then reacted under general reaction conditions to demonstrate the applicability this reactivity chart in predicting the regioselectivity of the palladium-catalyzed direct arylation and benzylation reactions.

In addition to the literature in the link below, there is a lot of literature about this compound(Tricyclohexylphosphonium tetrafluoroborate)Computed Properties of C18H34BF4P, illustrating the importance and wide applicability of this compound(58656-04-5).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Laser photo-thermal therapy of epithelial carcinoma using pterin-6-carboxylic acid conjugated gold nanoparticles, published in 2021-12-31, which mentions a compound: 16961-25-4, Name is Hydrogen tetrachloroaurate(III) trihydrate, Molecular AuCl4H7O3, SDS of cas: 16961-25-4.

Gold nanoparticles functionalized with folic acid toward the internalization into cancer cells have received considerable attention recently. Folic acid is recognized by folate receptors, which are overexpressed in several cancer cells; it is limited in normal cells. In this work, pterin-6-carboxylic acid is proposed as an agonist of folic acid since the pterin-6-carboxylic acid structure has a pterin moiety, the same as folic acid that is recognized by the folate receptor. Here a simple photochem. synthesis of gold nanoparticles functionalized with pterin-6-carboxylic acid is studied. These conjugates were used to cause photothermal damage of HeLa cells irradiating with a diode laser of 808 nm. Pterin-6-carboxylic acid-conjugated gold nanoparticles caused the death of the cell after near-IR irradiation, dose-dependently. These results indicate a possible internalization of AuNPs via folate receptor-mediated endocytosis due to the recognition or interaction between the folate receptors of HeLa cells and pterin, P6CA.

In addition to the literature in the link below, there is a lot of literature about this compound(Hydrogen tetrachloroaurate(III) trihydrate)SDS of cas: 16961-25-4, illustrating the importance and wide applicability of this compound(16961-25-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem