Tag: M.W=300-400

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Development of genistein-loaded gold nanoparticles and their antitumor potential against prostate cancer cell lines, published in 2021-05-31, which mentions a compound: 16961-25-4, mainly applied to prostate cancer cell line genistein loaded gold nanoparticle antitumor; Flow cytometry; Genistein; Gold nanoparticles; Green nanotechnology; Prostate carcinoma cells; Viability assay, Related Products of 16961-25-4.

Soy isoflavone genistein (Gen) exerts beneficial effects against prostate cancer cells in vitro and in vivo. However, its use as a chemoprevention/therapeutic agent is largely limited due to its low bioavailability. In this study we synthesized two variants of a new delivery system, genistein-gold nanoparticles conjugates Gen@AuNPs1 and Gen@AuNPs2, by an environmentally friendly method, using a dual role of Gen to reduce Au3+ and stabilize the formed AuNPs, with no addnl. component. The formation of Gen@AuNPs was confirmed via UV-Vis spectroscopy, FTIR, and Raman spectra measurements. The spherical shape and uniform size of Gen@AuNPs1 and Gen@AuNPs2 (10 ± 2 and 23 ± 3 nm, resp.), were determined by transmission electron microscopy. The nano-conjugates also varied in hydrodynamic diameter (65.0 ± 1.7 and 153.0 ± 2.2 nm) but had similar neg. zeta potential (-35.0 ± 2.5 and -37.0 ± 1.6 mV), as measured by dynamic light scattering. The Gen loading was estimated to be 46 and 48%, for Gen@AuNPs1 and Gen@AuNPs2, resp. The antiproliferative activities of GenAuNPs were confirmed by MTT test in vitro on three malignant prostate carcinoma cell lines (PC3, DU 145, and LNCaP), while selectivity toward malignant phenotype was confirmed using non-cancerous MRC-5 cells. Flow cytometric anal. showed that the inhibition on cell proliferation of more potent Gen@AuNPs1 nano-conjugate is comparable with the effects of free Gen. In conclusion, the obtained results, including physicochem. characterization of newly synthesized AuNPs loaded with Gen, cytotoxicity, and IC50 assessments, indicate their stability and bioactivity as an antioxidant and anti-prostate cancer agent, with low toxicity against human primary cells.

As far as I know, this compound(16961-25-4)Related Products of 16961-25-4 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of Poly(4,4-dialkyl-cyclopenta[2,1-b:3,4-b’]dithiophene-alt-2,1,3-benzothiadiazole) (PCPDTBT) in a Direct Arylation Scheme, published in 2012-04-17, which mentions a compound: 58656-04-5, mainly applied to arylation polydialkyl cyclopentadithiophene benzothiadiazole, Application of 58656-04-5.

Poly(4,4-dialkyl-cyclopenta[2,1-b:3,4-b’]dithiophene-alt-2,1,3-benzothiadiazole) (PCPDTBT), a potentially interesting low bandgap donor copolymer for bulk heterojunction-type organic solar cells with a power conversion efficiency >5.5%, can be now synthesized in a direct arylation scheme starting from 4,4-dialkyl-cyclopenta[2,1-b:3,4-b’]dithiophene (CPDT) and 4,7-dibromo-2,1,3-benzothiadiazole (4,7-dibromo-BT) as monomers. The direct arylation procedure leads to PCPDTBT with an Mn of up to 40,000 and circumvents the use of costly diboronic acid/ester or distannyl monomers.

This literature about this compound(58656-04-5)Application of 58656-04-5has given us a lot of inspiration, and I hope that the research on this compound(Tricyclohexylphosphonium tetrafluoroborate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C18H34BF4P. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Tricyclohexylphosphonium tetrafluoroborate, is researched, Molecular C18H34BF4P, CAS is 58656-04-5, about Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer. Author is Cailly, Thomas; Dumas, Noe; Millet, Philippe; Lemaitre, Stephane; Fabis, Frederic; Charnay, Yves; Rault, Sylvain.

In the aim to find new radiotracers for the in vivo imaging of 5-HT4 receptors by ultra-high resolution quant. SPECT, we have developed the synthesis of a radioiodinated 5-HT4 ligand, I, using an iododestannylation procedure. The [125I]-ligand was obtained in a high radiochem. yield. Preliminary autoradiog. and ex vivo studies failed to show a specific labeling of 5-HT4 receptors.

This literature about this compound(58656-04-5)COA of Formula: C18H34BF4Phas given us a lot of inspiration, and I hope that the research on this compound(Tricyclohexylphosphonium tetrafluoroborate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of AuCl4H7O3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about Rapid identification of triptolide in Tripterygium wilfordii products by gold immunochromatographic assay. Author is Duan, Yaping; Luo, Jiaoyang; Liu, Congmin; Shan, Linan; Dou, Xiaowen; Yang, Shihai; Yang, Meihua.

Triptolide colloidal gold immunoassay strip was prepared by using colloidal gold labeled monoclonal antibody purified with saturated ammonium sulfate, triptolide succinate-bovine serum albumin and sheep anti-mouse IgG for the first time in our laboratory Under optimized conditions, the detection limit of TP strip prepared in this study were determined to be 1μg/mL and the total anal. time (including sample preparation) was less than 50 min. Sixty-six batches of Tripterygium wilfordii (T. wilfordii) and its adulterations were analyzed. It was found that 28 batches of T. wilfordii were pos. as detected by the strips and 38 batches were neg. The result of test strip detection was in consistent with that from the UFLC-ESI-MS/MS method. Gold immunochromatog. assay was demonstrated as a rapid, cost-effective, reliable technique for on-site screening of T. wilfordii and its preparations The prepared colloidal gold immunoassay strip can be conveniently used for rapid identification of triptolide containing products.

This literature about this compound(16961-25-4)Computed Properties of AuCl4H7O3has given us a lot of inspiration, and I hope that the research on this compound(Hydrogen tetrachloroaurate(III) trihydrate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 58656-04-5, is researched, Molecular C18H34BF4P, about Sequential C3 and C5 Direct C-H Arylation of Imidazo[1,2-a]pyrazines with (Hetero)aryl Bromides, the main research direction is regioselective arylation imidazopyrazine aryl heteroaryl bromide.HPLC of Formula: 58656-04-5.

An efficient reaction manifold for the preparation of C3/C5-diarylimidazo[1,2-a]pyrazines through sequential C3 and C5 direct arylation is disclosed. The two distinct palladium catalyst systems showcased herein are compatible with a wide variety of aryl and heteroaryl bromides and are also operative in a one-pot, twofold C-H functionalization event. E.g., in presence of Pd(OAc)2, tricyclohexylphosphonium tetrafluoroborate, PivOH, and K2CO3 in DMF under a flow of N2, arylation of imidazo[1,2-a]pyrazine with 1-bromo-4-(ethylthio)benzene gave the C3 aryl product I (56%). Arylation of I with 4-bromoisoquinoline in presence of Pd(OAc)2, 1,10-phenanthroline, and Cs2CO3 gave 35% C3/C5-diaryl product II.

This literature about this compound(58656-04-5)HPLC of Formula: 58656-04-5has given us a lot of inspiration, and I hope that the research on this compound(Tricyclohexylphosphonium tetrafluoroborate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Selective C-N Bond Cleavage of N-Acylisatins: Towards High Performance Acylation/Arylation/Transamination Reagents》. Authors are Xiong, Li; Deng, Rong; Liu, Tingting; Luo, Zhongfeng; Wang, Zijia; Zhu, Xiao-Feng; Wang, Hui; Zeng, Zhuo.The article about the compound:Tricyclohexylphosphonium tetrafluoroboratecas:58656-04-5,SMILESS:F[B-](F)(F)F.[PH+](C1CCCCC1)(C2CCCCC2)C3CCCCC3).Quality Control of Tricyclohexylphosphonium tetrafluoroborate. Through the article, more information about this compound (cas:58656-04-5) is conveyed.

New multipurpose arylation/acylation/transamination reagents, N-acylisatins, I (R = Ph, Me, furan-2-yl, cyclohexyl, etc.) have been developed by selective ‘inside-outside’ C-N bond cleavage under different catalytic conditions. As activated amides, N-acylisatins I undergo Rh-catalyzed C-H arylation and Pd-catalyzed acylation by cleavage outside the C-N bond, and the desired biaryls RR1 (R1 = benzo[h]quinolin-10-yl, 5-methyl-1-(pyrimidin-2-yl)-1H-indol-2-yl, 3-methyl-1-(pyrimidin-2-yl)-1H-indol-2-yl, etc.) and diaryl ketones R2C6H4C(O)C6H5 (R2 = H, 4-Me, 3-OMe, 4-F, etc.) were obtained in good to excellent yields. Generally, the combination of N-acylisatins I (R = Ph, (A)) with amines such as N-methylaniline, 2-methylpropan-2-amine, aniline leads to a ring-opening reaction and formation of transamination products 2-(PhC(O)NH)C6H4C(O)C(O)NR3R4 (R3 = H, Me; R4 = Ph, t-Bu) in a predictable manner through inside C-N bond cleavage. Interestingly, treatment of N-acylisatins (A) with amines lead to unexpected outer-ring transamination products PhC(O)NR3R4 when CsF is added, which shows that CsF can favor the outside C-N bond cleavage path. Notably, this work presents a new strategy for multiple chem. transformations of a single amide to achieve various products by selective C-N bond cleavage.

This literature about this compound(58656-04-5)Quality Control of Tricyclohexylphosphonium tetrafluoroboratehas given us a lot of inspiration, and I hope that the research on this compound(Tricyclohexylphosphonium tetrafluoroborate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Facile synthesis of silver-rich Au/Ag bimetallic nanoparticles with highly active SERS properties, published in 2019, which mentions a compound: 16961-25-4, mainly applied to protein anaylsis immunoassay silver gold bimetallic nanoparticle SERS, Quality Control of Hydrogen tetrachloroaurate(III) trihydrate.

The sensitive detection of proteins has attracted great interest in biomedical research since abnormal concentrations of certain proteins often indicate the presence of various chronic diseases. In this work, we propose an immunoassay method based on surface-enhanced Raman scattering (SERS) for the proof-of-concept determination of proteins by using Atto-610 labeled Au/Ag bimetallic nanoparticles (BNPs) as nanotags and a Au/Ag bimetallic film as a substrate. Without the need for added surfactants or organic precursors during the preparation process, silver-enriched Au/Ag BNPs are obtained with relatively clean surfaces by combining a galvanic replacement (GR) reaction with co-reduction of Ag atoms. The changes in morphol., composition and surface plasmon resonance (SPR) involved in the GR reaction are systematically characterized, and the possible mechanism is discussed. The BNPs exhibit considerable SERS activity due to the enrichment of Ag in the nanostructures. Upon the introduction of AuNPs by gold staining, a SERS-based super-sandwich structure is generated that is suitable for immunoassays. Using this approach, rabbit IgG is detected over a wide concentration range with a detection limit of 10 pg L-1.

This literature about this compound(16961-25-4)Quality Control of Hydrogen tetrachloroaurate(III) trihydratehas given us a lot of inspiration, and I hope that the research on this compound(Hydrogen tetrachloroaurate(III) trihydrate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

HPLC of Formula: 3229-00-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Pentaerythrityltetrabromide, is researched, Molecular C5H8Br4, CAS is 3229-00-3, about Synthesis of photoresponsive dendrimers with a pentaerythrityl tetraazobenzene core. Author is Szalai, Michael L.; McGrath, Dominic V..

Dendrimers are well-defined macromols. having an inherently globular shape. Precise placement of photochromic moieties within a dendrimer interior could lead to reversible, photoinduced property/behavior alteration. Interest lies in the effect of azobenzene photochem. E/Z isomerization on dendrimer properties. Incorporation of three azobenzene subunits at the core of a dendrimer has resulted in materials with both photomodulated size and polarity and dendrimers with four discrete states. The effect of increasing azobenzene content as well as altering the core geometry was explored. Incorporation of four azobenzene moieties at the dendrimer core will make possible the existence of five discrete mol. states depending on the E/Z configuration of the individual azobenzenes (EEEE, EEEZ, EEZZ, EZZZ, ZZZZ). The synthesis of tetraazobenzene-containing dendrimers having a tetrahedral pentaerythrityl-based core was presented.

As far as I know, this compound(3229-00-3)HPLC of Formula: 3229-00-3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Materials Science & Engineering, C: Materials for Biological Applications called Construction and evaluation of tumor nucleus-targeting nanocomposite for cancer dual-mode imaging – Guiding photodynamic therapy/photothermal therapy, Author is Zhou, Jie; Wang, Qiaolei; Geng, Shizhen; Lou, Rui; Yin, Qianwen; Ye, Weiran, which mentions a compound: 16961-25-4, SMILESS is Cl[Au-](Cl)(Cl)Cl.[H]O[H].[H]O[H].[H]O[H].[H+], Molecular AuCl4H7O3, Application In Synthesis of Hydrogen tetrachloroaurate(III) trihydrate.

To tackle the barrier of the insufficient intra-cellular delivery of reactive oxygen species (ROS) and heat, we designed a multifunctional nanoplatform to release ROS and heat directly in the cell nucleus for enhancing combined photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors. As a photothermal agent, WS2 nanoparticles were adsorbed photosensitive Au25(Captopril)-18 (Au25) nanoclusters via electrostatic interaction. And Dexamethasone (Dex), a glucocorticoid with nucleus targeting capability, played a key role in the intra-nuclear process of heat and ROS. PTT can increase intra-tumoral blood flow to promote Au25 produce more ROS for PDT. Under near IR (NIR) laser irradiation at a single 808 nm, these nucleus targeting WS2 nanoplatforms showed a significant decreased cell viability of 18.2 ± 1.7% and a high DNA damage degree of 59.6 ± 8.3%. Furthermore, the WS2 nanoplatform could be further used for X-ray computed tomog. (CT) images. Taken together, our study provided a new prospect for effectively diagnostic and enhancing PTT/PDT efficacy.

As far as I know, this compound(16961-25-4)Application In Synthesis of Hydrogen tetrachloroaurate(III) trihydrate can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3229-00-3, is researched, SMILESS is BrCC(CBr)(CBr)CBr, Molecular C5H8Br4Journal, Zeitschrift fuer Naturforschung, Teil A: Astrophysik, Physik und Physikalische Chemie called Vibrational spectra of pentaerythritol derivatives. I. Vibrational spectra and normal coordinate treatment of tetrahalides of pentaerythritol, Author is Geiseler, Gerhard; Ratz, Lothar, the main research direction is PENTAERYTHRITYL HALIDE SPECTRA.Recommanded Product: Pentaerythrityltetrabromide.

The ir absorption spectra (4000-400 cm.-1) and the Raman spectra of the pentaerythrityl halides have been examined By comparison with the spectra of similar compounds and by a normal coordinate analysis with the aid of the Wilson GF-matrix method and on the basis of a modified valence force field, it was possible to assign a great deal of the normal vibration. The influence of the halogen atoms on the frequency of characteristic vibrations was discussed.

There is still a lot of research devoted to this compound(SMILES：BrCC(CBr)(CBr)CBr)Recommanded Product: Pentaerythrityltetrabromide, and with the development of science, more effects of this compound(3229-00-3) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem