Tag: M.W=300-400

Adding a certain compound to certain chemical reactions, such as: 33016-47-6, name is 1-Trityl-1H-imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33016-47-6, Recommanded Product: 33016-47-6

Under argon atmosphere, 5.6 ML (2.96 mmol, 1 equivalent) of the solution of ethyl bromozincacetate in tetrahydrofuran obtained in Example 43 was added dropwise to a solution of 1 g (2.96 mmol) of 1-trityl-1H-imidazol-4-carbaldehyde in 10 ML of THF at 3?6C. The mixture was stirred at 0?5C for 1 hour and 25 minutes. 5.6 ML (2.96 mmol, 1 equivalent) of the solution of ethyl bromozincacetate in tetrahydrofuran obtained in Example 43 was added dropwise at 0?3C. The mixture was stirred at 2?3C for 5 hours and 30 minutes. 5 ML of 1N hydrochloric acid was added dropwise at 20C or lower, followed by dilution with 30 ML of ethyl acetate.. Then, the layers were separated.. The organic layer was washed successively with 5 ML of 1N hydrochloric acid, 5 ML of water, 5 ML (*2) of an aqueous saturated sodium bicarbonate solution, and 5 ML (*2) of an aqueous saturated sodium chloride solution.. After washing, the organic layer was dried with anhydrous magnesium sulfate.. After concentration under reduced pressure, recrystallization with 3 ML of IPE afforded 1.16 g of the desired product (yield 92%).1H NMR (CDCl3): delta 1.22 (3H, t, J=7.1 Hz), 2.83-2.86 (2H, m), 4.13 (2H, q, J=7.1 Hz), 5.09-5.13 (1H, m), 6.78 (1H, s), 7.10-7.15 (6H, m), 7.26-7.39 (10, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Trityl-1H-imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1471056; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 2034-22-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2034-22-2 name is 2,4,5-Tribromoimidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A dried 500 mL round bottom flask was charged with 2,4,5-tribromoimidazole (5 1, 20.0 g, 65.6 mmol) and anhydrous DMF (100 mL), and the resulting solution was cooled to 0C. To this cold solution was added NaH (60% in mineral oil, 2.80 g, 70.0 mmol) portionwise with gas evolution under control and an internal temperature maintained below l0C. After addition, the cold bath was removed and the resulting mixture was stirred at ambient temperature for 30 minutes. The reaction mixture was cooled back to 0C, and SEMC1 (12.2 mL, 69.5 mmol) was added to the reaction via syringe pump over 30 minutes. The reaction was stirred at 0C for an additional 30 minutes and at room temperature for another 30 minutes. The mixture was partitioned between EtOAc (150 mL) and water (300 mL), the organic phase was washed with dilute aqueous NaCl (5percent w/w) twice, then brine (100 mL), dried (Na2S04), and concentrated. The crude material was re-crystallized from hot petroleum ether (30 mL) and the solids were harvested from the mother liquor at 0C. The product was washed with cold petroleum ether (30 mL) and dried under vacuum to afford 2,4,5-tribromo-l-((2-(trimethylsilyl)ethoxy)methyl)-lH-imidazole (5_2). 1H MR (400 MHz, CDCh) d 5.31 (s, 2H), 3.59 (t, J= 7.2 Hz, 2H), 0.92 (t, J= 7.2 Hz, 2H), -0.01 (s, 9H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4,5-Tribromoimidazole, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; CLAUSEN, Dane James; YU, Wensheng; KELLY, Joseph, M.; KIM, Hyunjin, M.; KOZLOWSKI, Joseph, A.; (202 pag.)WO2020/28150; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 2620-76-0, name is 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2620-76-0, Recommanded Product: 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole

A mixture of Compound 2 (0.70 g, 2 mmol), bis(pinacolate)diborane (0.533 g, 2.1 mmol), bis(diphenylphosphino)ferrocene]dichloropalladium (Pd(dppf)C12) (0.060 g,0.08 mmol) and anhydrous potassium acetate (KOAc) (0.3 93g, 4 mmol) in 1 ,4-dioxane (20 ml) was heated at 80 C. under argon overnight. Afier cooling to RT, the whole was diluted with ethyl acetate (80 ml) then filtered. The solution wasabsorbed on silica gel, then purified by column chromatog-raphy (hexanes/ethyl acetate 5:1 to 3:1) to give a white solid3 (0.64 g, in 81% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Khan, Sazzadur Rahman; Zheng, Shijun; Li, Sheng; Mochizuki, Amane; Okada, Keisaku; US2015/87685; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 103057-10-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 103057-10-9 name is 4-(Chloromethyl)-1-trityl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

REFERENCE EXAMPLE 34 Ethyl 5,6-Dimethoxy-1-(1-trityl-4-imidazolyl)methyl-1H-indazole-3-carboxylate In 5000 ml of dimethyl sulfoxide was suspended 250.2 g of ethyl 5,6-dimethoxyindazole-3-carboxylate, and 40.2 g of lithium methoxide was added to the suspension, followed by stirring at room temperature for 1 hour. A solution of 447.8 g of 4-chloromethyl-1-tritylimidazole in 2000 ml of dimethyl sulfoxide was added dropwise thereto at room temperature over 10 minutes. After stirring at room temperature for 2 hours, 4.2 g of lithium methoxide and 44.8 g of 4-chloromethyl-1-tritylimidazole were further added thereto, followed by stirring at room temperature for 1 hour. The reaction mixture was poured into 30000 ml of ice-water while stirring. A precipitated crystal was collected, washed with three 2000 ml portions of water, and dried. The solid was dissolved in 10000 ml of chloroform, and the solution was dried over sodium sulfate, filtered, and the solvent was evaporated. The residue was purified by silica gel column chromatography (chloroform:ethanol=50:1) and recrystallized from chloroform/isopropyl alcohol to yield 222.0 g of the title compound as a colorless prism crystal. Melting point: 184-186 C.; IR (KBr) cm-1: 1704, 1496, 1268, 1146, 1132, 1092, 748, 700; 1 H-NMR (CDCl3) delta ppm: 1.21 (6H, d, J=5.9 Hz, Me of iso-PrOH), 1.46 (3H, t, J=7.3 Hz), 3.93 (3H, s), 3.97 (3H, s), 4.01 (1H, m, CH of iso-PrOH), 4.49 (2H, q, J=7.3 Hz), 5.61 (2H, s), 6.79 (1H, s), 7.03 (5H, m), 7.13 (1H, s), 7.28 (10H, m), 7.47 (1H, s), 7.51 (1H, s); Elementary analysis for C35 H32 N4 O4.C3 H8 O: Calcd. (%): C 72.13; H 6.37; N 8.85; Found (%): C 71.53; H 6.37; N 8.70.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Chloromethyl)-1-trityl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Patent; Daiichi Pharmaceutical Co., Ltd.; US5681954; (1997); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, A new synthetic method of this compound is introduced below., COA of Formula: C19H20N4

General procedure: To a solution of 1,7′-dimethyl-2′-propyl-1H,3’H-2,5′-bibenzo[d]imidazole 3 (2 mmol) and tetrabutylammonium bromide (0.2 mmol) in benzene (25 mL), a solution of 50% NaOH (25 mL) was added at 0 C followed by the addition of sulfonyl chloride 4 (2.2 mmol). The reaction mixture was stirred vigorously at room temperature for 5-6 h and the reaction was monitored by TLC. After the completion of the reaction, aqueous phase was separated and the organic phase was washed with water (20 mL) and brine (20 mL), dried over anhydrous sodium sulphate and concentrated to give crude products which were purified by column chromatography over silica gel using hexane-EtOAc (6:4) mixture as eluent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Roopashree, Rangaswamy; Mohan, Chakrabhavi Dhananjaya; Swaroop, Toreshettahally Ramesh; Jagadish, Swamy; Raghava, Byregowda; Balaji, Kyathegowdanadoddi Srinivas; Jayarama, Shankar; Basappa; Rangappa, Kanchugarakoppal Subbegowda; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2589 – 2593;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 33016-47-6,Some common heterocyclic compound, 33016-47-6, name is 1-Trityl-1H-imidazole-4-carbaldehyde, molecular formula is C23H18N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1Under a nitrogen atmosphere, 6-bromo-N-methyl-2- naphthamide (7.0 g, 26.5 mmol) was added to tetrahydrofuran (175 mL) , and then 2.0 mol/L isopropylmagnesium chloridetetrahydrofuran solution (13.7 mL) was added dropwise thereto at room temperature. The reaction mixture was cooled to -30C, 1.6 mol/L n-butyllithium hexane solution (26.6 mL) was added dropwise thereto, and the mixture, was stirred at the same temperature for 2 hr. To the reaction mixture was addeddropwise a solution of l-trityl-4-formyl-lH-imidazole (13.5 g, 39.9 mmol) in tetrahydrofuran (140 mL) at -20C, and themixture was stirred at the same temperature for 2 hr. The reaction mixture was allowed to warm to 0C, and stirred for 1 hr, and 20w/v% aqueous ammonium chloride solution (105 mL) was added dropwise thereto. The organic layer was separated, and concentrated to the volume of about 90 mL under reducedpressure. To the residue was added tetrahydrofuran (140 mL) , and the mixture was concentrated to the volume of about 90 mL under reduced pressure. To the residue was added acetone (140 mL) , and the mixture was concentrated to the volume of about 140 mL under reduced pressure. These operations were repeated three times. To the residue was added acetone to adjust the volume to about 180 mL, and the mixture was stirred at room temperature. The crystals were collected by filtration, and washed with acetone (70 mL) . The obtained wet crystals were dried under reduced pressure to give 6- [hydroxy ( 1-trityl-lH- imidazol-4-yl) methyl] -N-methyl-2-naphthamide (10.3 g, 19.7 mmol) . yield 74%.½ NMR (500 MHz , DMSO-d6) delta 2.84 (d, J = 4.7 Hz, 3H) , 5.76 (d, J = 5.0 Hz, 1H), 5.82 (d, J = 4.7 Hz, 1H) , 6.80 (s, 1H) , 6.98- 7.13 (m, 6H) , 7.28 (d, J = 1.6 Hz, 1H) , 7.32-7.50 (m, 9H) , 7.55 (dd, J = 8.5, 1.6. Hz, 1H) , 7.83-7.99 (m,. 4H) 8.37 (s, 1H) 8.58 (d, J = 4.4 Hz, 1H) ; HRMS (ESI) m/z Calcd for aC35H30 3O2 [M+H] +: 524.2338, Found: 524.2325; Anal. Calcd for a C35H29 3O2: C, 80.28; H, 5.58; N, 8.02. Found: C, 80.17; H, 5.80; N, 7.81.[0097]

The synthetic route of 33016-47-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KAWABATA, Yoichi; SAWAI, Yasuhiro; KANNO, Kazuaki; SAWADA, Naotaka; WO2012/173280; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 2620-76-0,Some common heterocyclic compound, 2620-76-0, name is 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole, molecular formula is C19H13BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[Example 4] This example will give descriptions of a method of synthesizing 2-[4-(6-phenyldibenzothiophen-4-yl)phenyl]-1-phenyl-1H-benzimidazole (abbreviation: DBTBIm-IV) represented by the following Structural formula (188). [Show Image] [Synthesis of 2-[4-(6-phenyldibenzothiophen-4-yl)phenyl]-1-phenyl-1H-benzimidazole (abbreviation: DBTBIm-IV)] The synthesis scheme of 2-[4-(6-phenyldibenzothiophen-4-yl)phenyl]-1-phenyl-1H-benzimidazole (abbreviation: DBTBIm-IV) is illustrated in (B-4). [Show Image] In a 100-mL three-neck flask, a mixture of 1.7 g (5.0 mmol) of 2-(4-bromophenyl)-1-phenyl-1H-benzimidazole, 1.5 g (5.0 mmol) of 6-phenyldibenzothiophen-4-boronic acid, 22 mg (0.1 mmol) of palladium(II) acetate, 60 mg (0.2 mmol) of tri(ortho-tolyl)phosphine, 20 mL of toluene, 2 mL of ethanol, and 7.5 mL of a 2 mol/L aqueous solution of potassium carbonate was stirred to be degassed under reduced pressure. Then, the mixture was heated and stirred at 90 °C for 2.5 hours under a nitrogen stream. After a predetermined time, 150 mL of toluene was added to this mixture solution, and the organic layer of the resulting suspension was suction filtered through Celite (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 531-16855). The resulting filtrate was concentrated, followed by purification using silica gel column chromatography. The silica gel column chromatography was carried out using a mixed solvent of toluene and ethyl acetate in a ratio of 19 to 1 as a developing solvent. The obtained fractions were concentrated, and acetone and methanol were added to the mixture, followed by irradiation with ultrasonic waves. The precipitated solid was collected by suction filtration. Thus, 2.2 g of a white powder was obtained in 83percent yield, which was the substance to be produced. The Rf values of the produced substance and 2-(4-bromophenyl)-1-phenyl-1H-benzimidazole were respectively 0.21 and 0.36, which were found by silica gel thin layer chromatography (TLC) (with a developing solvent containing ethyl acetate and hexane in a ratio of 1 to 5). The nuclear magnetic resonance (NMR) measurement identified this compound as 2-[4-(6-phenyldibenzothiophen-4-yl)phenyl]-1-phenyl-1H-benzimidazole (abbreviation: DBTBIm-IV). 1H NMR data of the obtained compound are as follows: 1H NMR (CDCl3, 300 MHz): delta (ppm) = 7.26-7.59 (m, 15H), 7.64-7.71 (m, 6H), 7.90-7.93 (d, J = 7.8 Hz, 1H), 8.15-8.19 (m, 2H). FIGS. 18A and 18B illustrate the 1H NMR charts. Note that FIG. 18B is a chart showing an enlarged part of FIG. 18A in the range of 7.0 ppm to 8.5 ppm. Further, FIG. 19A shows an absorption spectrum of a toluene solution of DBTBIm-IV, and FIG. 19B shows an emission spectrum thereof. FIG. 20A shows an absorption spectrum of a thin film of DBTBIm-IV, and FIG. 20B shows an emission spectrum thereof. The absorption spectrum was measured using an ultraviolet-visible spectrophotometer (V-550, produced by JASCO Corporation). The measurements were performed with samples prepared in such a manner that the solution was put in a quartz cell while the thin film was obtained by evaporation onto a quartz substrate. The absorption spectrum of the solution was obtained by subtracting the absorption spectra of quartz and toluene from those of quartz and the solution, and the absorption spectrum of the thin film was obtained by subtracting the absorption spectrum of a quartz substrate from those of the quartz substrate and the thin film. In FIGS. 19A and 19B and FIGS. 20A and 20B, the horizontal axis represents wavelength (nm) and the vertical axis represents intensity (arbitrary unit). In the case of the toluene solution, an absorption peak was observed at around 316 nm and emission wavelength peaks were 371 nm and 387 nm (excitation wavelength: 320 nm). In the case of the thin film, absorption peaks were observed at around 242 nm, 304 nm, and 319 nm, and an emission wavelength peak was 402 nm (excitation wavelength: 349 nm).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole, its application will become more common.

Reference:
Patent; SEMICONDUCTOR ENERGY LABORATORY CO., LTD.; EP2354135; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 152628-02-9, These common heterocyclic compound, 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of an appropriate benzimidazole (5.03mmol) and NaH (0.12g, 5.53mmol, 60%) in 100mL anhydrous THF was stirred for 30minat 50C. After cooling to rt, a mixture of an appropriate bromide (6.04mmol) in anhydrous THF (50mL) was added dropwise to the solution. The solution was stirred for 3hat 50C. Then the resulting mixture was poured into 30mL ice water, and extracted with ethyl acetate (50mL×3). The combined organic layer was dried over MgSO4. After filtration, the solvent was removed under reduced pressure and the residue was purified by CC to give the product as white solid 4.1.7.3 [4-[[2-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl](phenyl)methanone (12c) 12c was prepared by following the above general procedure. Yield: 91.9%. MP: 214-216 C. 1H NMR (400 MHz, CDCl3): delta 8.34 (d, 1H), 8.04 (s, 1H), 7.27-7.73 (m, 12H), 6.74 (d, 1H), 6.52 (d, 1H), 5.67 (s, 2H), 3.89 (s, 3H), 2.89 (t, 2H), 2.78 (s, 3H), 1.85 (m, 2H), 1.02 (t, 3H). MS (ESI): [M + H]+ calcd 538.3; found 538.3.

The synthetic route of 152628-02-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhu, Weibo; Bao, Xiaolu; Ren, He; Da, Yajing; Wu, Dan; Li, Fuming; Yan, Yijia; Wang, Li; Chen, Zhilong; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 161 – 178;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15469-97-3 as follows. HPLC of Formula: C22H18N2

Compounds 6 and 7: To a solution of tritylimidazole (2.67 g, 8.6 mmol) in THF (85 ml) cooled to -20 C a stock 1.6 M solution n-butyl lithium in hexanes (5.13 ml, 8.2 mmol) was added dropwise. The resulting wine red coloured solution was allowed to warm up to RT and stirred for 30 min. The solution was then cooled to -78 C and a solution of aldehyde (4.17 g, 7.8 mmol) in THF (15ml) was added dropwise. The resulting solution was stirred for 30 min and then allowed to warm to RT in 30 min. The reaction was quenched by addition of ammonium chloride solution and extracted with ethyl acetate. The aqueous layer was extracted with ethyl acetate once more. The combined organic layer was dried and evaporated. The residue was purified by flash column chromatography in PE-EA gradient 10-20-30percent to give 1.18 g (1.4 mmol, 18percent) of 6 (Rf = 0.55 PE- EA 20percent) and 3.48 g (4.13 mmol, 53percent) of 7 (Rf = 0.4 PE-EA 20percent) .6: [?]D = -10.5 c 1.24 CHCl3HRMS: Positive mode, m/z = 845.4344; expected for C54H6IN2O5Si [M+H]+ = 845.4350.?H (500 MHz) : 0.0 and 0.02 (6H, 2*s, -Si (CH3) C (CH3) 3) , 0.89 (9H, s, -Si(CH3)C(CH3)S) , 2.94 (IH, dd, J4, 5 = 6.5 Hz, J4/3 = 4.1 Hz, H-4) , 3.1 (IH, bs, 2-OH) , 3.14 (IH, dd, J6a,5 = 5.4, Jea,6b = 10.2 Hz, H-6a) , 3.37 (IH, dd, J6b,5 = 3 Hz, H- 6b) , 3.8 (IH, dd, J3, 2 = 3.2 Hz, H-3) , 3.93 (IH, ddd, H-5) , 3.97 and 4.41 (2H, AB spectrum, Jgem = 11.5 Hz, PhCH2O-) , 4.3 (IH, bs, H-2) , 4.33 (2H, s, PhCH2O-) , 4.71 and 4.93 (2H, AB spectrum, Jgem = 11.2 Hz, PhCH2O-) , 6.78 (IH, m) , 7.02 (2H, m) , 7.13-7.4 (28H, m) .?c (125 MHz) : -4.4, 18.2, 26.1, 66.6 (C-2) , 72.8 (C-6) , 72.9 (C-5) , 73.2, 73.8, 74.4, 75.3, 78.8 (C-3) , 81.7 (C-4) , 122.2, 126.08, 127.06, 127.3, 127.4, 127.8, 128.1, 128.3, 128.5, 130, 138.6, 138.8, 138.9, 142.9, 150.7.7: [?]D = -67.5 c 1.34 CHCl3HRMS: Positive mode, m/z = 845.4344; expected for C54H6IN2O5Si [M+H]+ = 845.4350.?H (500 MHz) : -0.09 and 0.0 (6H, 2*s, -Si (CH3) C (CH3) 3) , 0.82 (9H, s, -Si (CH3) C (CH3) 3) , 3.52 (IH, dd, J6a,5 = 6.5 Hz, J6a,6b = 10.4 Hz, H-6a) , 3.73 (IH, dd, J4, 5 = 7.3, J4, 3 = 2.6 Hz, H- A) 1 3.78 (IH, dd, J6b,5 = 2.2 Hz, H-6b) , 4.12 (IH, ddd, J5, 4 =6.7 Hz, H-5) , 4.24 (IH, dd, J3, 2 = 8.7 Hz, H-3) , 4.27 and 4.57 (2H, AB spectrum, Jgem = 12.4 Hz, PhCH2O-) , 4.41 (2H, s, PhCH2O-) , 4.48 and 4.6 (2H, AB spectrum, Jgem = 10.7 Hz, PhCH2O-) , 4.5 (IH, dd, J2, 0H = 4 Hz, H-2) , 6.79 (IH, m) , 6.85-7.4 (31H, m) .?c (125 MHz) : -4.7, 18.2, 26, 65.9 (C-2) , 72.6 (C-5) ,73.1, 73.2 (C-6) , 73.8, 75.5, 79.6 (C-4) , 80.13 (C-3) , 122.3, 125.9, 126.17, 126.5, 127, 127.2, 127.6, 127.8,127.9, 128.1, 128.4, 128.6, 130, 130.2, 138.7, 139, 139.3, 141, 142.5, 150.2 (C-I) .

According to the analysis of related databases, 15469-97-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE; WO2008/59267; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 760212-58-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 760212-58-6, name is 1-(4-Bromophenyl)-2-phenyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.

Intermediate I-3 4.23 g (11.0 mmol), Intermediate I-4 3.49 g (10.0 mmol), Pd (PPh3) 4 0.06 g (0.5 mmol) and K2CO34.15 g (30.0 mmol) of THF/H2O (2/1 volume ratio) mixed solution and then dissolved in 40 mL, was stirred at 80 for 5 hours. after cooling to room temperature the reaction solution was added to 40 mL water and extracted three times with diethyl ether, 50 mL. The combined organic layers were dried over magnesium sulfate, and separation of the residue obtained by evaporation of the solvent by silica jelgwan chromatography to give the compound 4 4.33 g (yield 81%). The resulting compound was confirmed by LC-MS and 1H NMR.

The chemical industry reduces the impact on the environment during synthesis 1-(4-Bromophenyl)-2-phenyl-1H-benzo[d]imidazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Samsung Display Co., Ltd.; Kim, Young Kuk; Kim, Kwang Hyun; Lee, Uhn Young; (77 pag.)KR2015/39485; (2015); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem