Tag: M.W=300-400

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31250-80-3, name is 1-Benzyl-2,4,5-tribromo-1H-imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H7Br3N2

Reflux a mixture of [1-BENZYL-2,] 4, [5-TRIBROMOIMIDAZOLE] (1.043 g, 2.42 mmol), 2,4- difluorophenyl boronic acid (0.682 g, 4.32 mmol), palladium acetate (0.027 g, 0.12 mmol), R (+) -2, 2′-bis [(DI-P-TOLYL-PHOSPHINO) 1, 1′-BINAPHTHYL] (0.098 g, 0.14 mmol), 2 M sodium carbonate (3.6 [ML,] 4.83 mmol), methanol (3.6 [ML)] and toluene (36 mL) for [18] hours. Cool to ambient temperature and dilute with ethyl acetate. Wash with saturated sodium carbonate, saturated sodium chloride, dry with magnesium sulfate and purify the residue on silica gel eluting with hexane/ethyl acetate mixtures to provide [1-BENZYL-4,] 5- [DIBROMO-2- (2, 4-DIFLUORO-PHENYL)-LH-IMIDAZOLE] (0.39 g). MS [(ES+)] : [NILZ] = 461.1 (M+H) [+]

The synthetic route of 31250-80-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2004/14900; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 50257-40-4,Some common heterocyclic compound, 50257-40-4, name is 1-((2,4,6-Triisopropylphenyl)sulfonyl)-1H-imidazole, molecular formula is C18H26N2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred suspension of NaH (60percent in oil dispersion) (2.9 g, 72 mmol) in dry THF (240 mL) at 0C was added in portions 7 (3.8 g, 24 mmol), followed by 2,4,6-triisopropyl-benzenesulfonylimidazole (20 g, 60 mmol), and the whole mixture was then stirred for 3 h. Cold H2O (100 mL) was added, and the resulting mixture was extracted with EtOAc (3 × 40 mL). The combined extracts were washed with brine (50 mL) and then dried (anhydrous Na2SO4). Evaporation of the solvent gave the crude product, which contains 12 and its regioisomer 13 with a ratio of 3:1. The mixture was purified by flash chromatography on silica gel (hexane/EtOAc, 50:1) to afford 12 and 13. For 12 (4.1g, 41percent yield; colorless oil): [alpha]D20 +2.0 (c = 1.00, CH2Cl2); 94.6percent ee; 1H NMR (300 MHz, CDCl3): delta 1.04 (t, J = 7.5 Hz, 3 H), 1.22-1.29 (m, 18 H), 2.01-2.08 (m, 2 H), 2.60-2.70 (m, 2 H), 2.81 (dd, J = 2.55, 4.81 Hz, 1 H), 2.90-2.93 (m, 2 H), 3.20-3.28 (m, 1 H), 4.12-4.16 (m, 2 H), 4.50-4.54 (m, 1 H), 7.18 (s, 2 H); 13C NMR (75 MHz, CDCl3): delta 12.3, 14.0, 23.0, 23.6, 24.7, 24.8, 29.8, 34.3, 45.5, 52.4, 72.8, 79.4, 85.2, 123.8, 130.7, 150.6, 153.7; HRMS (ESI): m/z [M+Na]+ calcd for C23H34O4SNa: 429.2070; found: 429.2073. For 13 (1.3g, 14percent yield; colorless oil): 1H NMR (400 MHz, CDCl3): delta 1.08 (t, J =7.5 Hz, 3H), 1.25-1.28 (m, 18H), 2.07-2.26 (m, 3H), 2.52-2.61 (m, 1H), 2.85-2.99 (m, 1H), 3.18-3.28 (m, 2H), 4.03-4.22 (m, 3H), 4.39 (dd, J = 3.81, 11.42 Hz, 1H), 7.20 (s, 2H); 13C NMR (100 MHz, CDCl3): delta 12.4, 14.0, 19.1, 23.7, 24.8, 24.8, 29.8, 34.4, 53.5, 54.7, 67.1, 73.1, 84.9, 124.0, 129.1, 151.0, 154.1; HRMS (ESI): m/z [M+Na]+ calcd for C23H34O4SNa: 429.2070; found: 429.2073. The enantiomeric excess of 12 was determined by chiral HPLC analysis (column, Chiralpak AD-H, 4.6 mm × 250mm, n-hexane / i-PrOH = 97:3; flow rate: 0.5 mL/min, lambda = 230nm). The retention times corresponding to 12 and its enantiomer are 12.8 min and 10.2 min, respectively.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-((2,4,6-Triisopropylphenyl)sulfonyl)-1H-imidazole, its application will become more common.

Reference:
Article; Xu, Kai; Zhao, Shuai; Xu, Jia-Kuan; Shan, Ming-Wei; Yu, Jia-Li; Wang, Yu-Bo; Zhang, Cheng-Fang; Chen, Xin; Synthetic Communications; vol. 47; 20; (2017); p. 1848 – 1853;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 914306-50-6,Some common heterocyclic compound, 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, molecular formula is C21H24N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 500 ml round bottom flask flushed with argon were introducedIrCl3.xH20 (6.48 g, 18.3 mmol) and l-(2,6-diisopropylphenyl)-2-phenyl-lH- imidazole ligand (16.74 g, 55 mmol) followed by addition of 356 ml of a 3: 1 (v/v) mixture of 2-ethoxy-ethanol and water. The resulting mixture was outgassed and heated under stirring at reflux for 21h. After cooling, the precipitate was filtered off with suction, washed with methanol and dried under vacuum. The reaction yield was 84 %.2nd step: preparation of a fac-isomer of the metal complex of formula (IV)A fac-isomer of the metal complex of formula (IV) was obtained in an identical manner to Example 1 except that l-(2,6-diisopropylphenyl)-2-phenyl- lH-imidazole was used as ligand instead of l-(2,6-dimethylphenyl)-2-phenyl- lH-imidazole. The fac-isomer yield estimated, as in example 1, from NMR analysis of the recovered precipitate is equal to 85 %; no mer-isomer was detected.

The synthetic route of 914306-50-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SOLVAY SA; VAN PEE, Veronique; CATINAT, Jean-Pierre; WO2012/84219; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, A new synthetic method of this compound is introduced below., Safety of 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole

Preparation of compound (15):0.39 g (1 .1 1 mmol) of iridium(lll) chloride trihydrate are dissolved in 1 1.5 ml of an argon-sparged solution consisting of three parts of 2-ethoxyethanol and one part of demineralized water, and also 0.71 g (2.33 mmol, 2.1 eq) of 1 -(2′,6′-di- isopropylphenyl)-2-phenyl-7/-/-imidazole (synthesized analogously to Example 14 in WO 2006/12181 1 ) at room temperature while stirring. The dark green solution is refluxed. Shortly after attainment of reflux, a yellow substance precipitates out. After reaction overnight, the pale yellow suspension cools down and is filtered off with suction. The residue which had been washed with methanol and finally with n-pentane was vacuum-dried at 50C to obtain 0.76 g (82% yield) of the product (15).1H NMR (CD2CI2, 400 MHz): delta = 0.93 (d, 3H), 1.17 (d, 3H), 1.25 (d, 3H), 1 .32 (d, 3H), 2.81 (m, 2H), 6.07 (d, 1 H), 6.23 (d, 1 H), 6.37 (dd, 1 H), 6.51 (dd, 1 H), 6.95 (s, 1 H), 7.39 (m, 2H), 7.56 (d, 1 H), 7.65 (s, 1 H).

The synthetic route of 914306-50-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; BASF (CHINA) COMPANY LIMITED; MOLT, Oliver; LENNARTZ, Christian; DORMANN, Korinna; FUCHS, Evelyn; GEssNER, Thomas; LANGER, Nicolle; WATANABE, Soichi; SCHILDKNECHT, Christian; WAGENBLAST, Gerhard; WO2012/20327; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

53525-60-3, name is Ethyl 1-trityl-1H-imidazole-4-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of Ethyl 1-trityl-1H-imidazole-4-carboxylate

To a stirred solution of compound LXIX (3 g; 8.87 mmol) and ethyl 1-trityl-1H-imidazole-4- carboxylate (XLV; 10 g; 26.62 mmol) in THF (50 ml) was added sodium bis(trimethylsilyl)amide (44 ml, 1 .OM in THF, 44.35 mmol) dropwise at 0C. Upon complete addition, the resultant solution was stirred at ambient temperature for 2 h. The reaction mixturewas diluted with a saturated solution of ammonium chloride and extracted with ethyl acetate. The organic layer was washed with brine solution and dried over anhydrous Na2SO4, filtered and evaporated under reduced pressure to obtain 4-(tert-butyl)-N-(5-chloro-6-(2-oxo-2-(1- trityl- 1 H-imidazol-4-yl)ethyl)pyridin-2-yl)benzenesulfonamide LXXV, as a keto-enol tautomeric mixture. MS (M+1): 675.12. The crude material was carried forward to next stepwithout purification.

The synthetic route of 53525-60-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NORGINE B.V.; BAKTHAVATCHALAM, Rajagopal; BASU, Manas Kumar; BEHERA, Ajit Kumar; VENKATESHAPPA, Chandregowda; HEWSON, Christopher Alexander; KADNUR, Sanjay Venkatachalapathi; KALINDJIAN, Sarkis Barret; KULKARNI, Bheemashankar; SAXENA, Rohit; SURESH, Juluri; VISWANATHAN, Vellarkad; ZAINUDDIN, Mohd; DHARSHINIS, Akila Parvathy; KRISTAM, Rajenda; WO2015/97122; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 914306-50-6 as follows. Computed Properties of C21H24N2

Synthesis of (OC-6-22)-bis{5-(9H-carbazol-9-yl)-2-[1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl-kappaN3]phenyl-kappaC}{2-[1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl-kappaN3]phenyl-kappaC}iridium(III) (abbreviation: [fac-Ir(iPrCzpim)2(iPrpim)]) (0430) First, 1.8 g (0.8 mmol) of [Ir(iPrCzpim)2Cl]2 and 150 mL of dichloromethane were put into a 200-mL three-neck flask. A solution obtained by dissolving 0.6 g (2.3 mmol) of silver trifluoromethanesulfonate in 62 mL of methanol in a dark place was put in a dropping funnel attached to the 200-mL three-neck flask in a dark place. This methanol solution of silver trifluoromethanesulfonate was added dropwise into the reaction solution, and stirring was performed at room temperature for 26 hours. After reaction for the predetermined time, the reaction solution was filtered through Celite and the solvent of the resulting filtrate was distilled off to give an ocher solid. Then, all of the obtained ocher solid, 0.94 g (3.1 mmol) of 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole (abbreviation: HiPrpim), 15 mL of methanol, and 15 mL of ethanol were put in a 200-mL three-neck flask, and the mixture was refluxed for 36 hours. After reaction for the predetermined time, the solvent of the reaction solution was distilled off to give a yellow solid. A solution obtained by dissolving this yellow solid in tetrahydrofuran (THF) was filtered through a filter aid in which Celite, neutral silica, and Celite were stacked in this order, so that a yellow solution was obtained. The solvent in this yellow solution was distilled off to give a yellow solid. This yellow solid was purified by silica gel column chromatography. Toluene was used as a developing solvent. The solvent of the resulting fraction was distilled off, so that a yellow oily substance was obtained. This yellow oily substance was recrystallized with ethyl acetate and hexane to give a yellow solid. Purification by a train sublimation method was performed on this yellow solid, so that 240 mg (0.17 mmol) of a yellow solid was obtained in a yield of 11%. The synthesis scheme is shown in (c-1). (0431) Protons (1H) of the yellow solid obtained as described above were measured by nuclear magnetic resonance (NMR). The obtained values are shown below. The 1H-NMR chart is shown in FIG. 32. The results revealed that [fac-Ir(iPrCzpim)2(iPrpim)], which is the organometallic complex represented by Structural Formula (600), was obtained in Synthesis Example 2. (0432) 1H-NMR. delta (CD2Cl2): 0.57 (d, 3H), 0.70 (d, 3H), 0.92 (m, 18H), 1.14 (d, 3H), 1.19 (dd, 6H), 1.24 (d, 3H), 2.27 (m, 1H), 2.34 (m, 1H), 2.54 (m, 1H), 2.62 (m, 2H), 2.81 (m, 1H), 6.07 (d, 1H), 6.27 (t, 2H), 6.39 (d, 1H), 6.44 (dd, 1H), 6.52 (t, 1H), 6.67 (dd, 1H), 6.82 (d, 1H), 6.90 (m, 7H), 6.99 (m, 8H), 7.12 (d, 1H), 7.22 (d, 1H), 7.34 (m, 9H), 7.49 (m, 3H), 7.90 (d, 2H), 7.95 (m, 2H). (0433) Next, an ultraviolet-visible absorption spectrum (absorption spectrum) and an emission spectrum of a dichloromethane solution of [fac-Ir(iPrCzpim)2(iPrpim)] were measured. The measurement of the absorption spectrum was conducted at room temperature, for which an ultraviolet and visible spectrophotometer (V550 type manufactured by JASCO Corporation) was used and the dichloromethane solution (0.0100 mmol/L) was put in a quartz cell. In addition, the measurement of the emission spectrum was performed at room temperature in such a manner that an absolute PL quantum yield measurement system (C11347-01 manufactured by Hamamatsu Photonics K.K.) was used and the deoxidized dichloromethane solution (0.0100 mmol/L) was sealed in a quartz cell under a nitrogen atmosphere in a glove box (LABstar M13 (1250/780) manufactured by Bright Co., Ltd.). Measurement results of the obtained absorption and emission spectra are shown in FIG. 33, in which the horizontal axis represents wavelength and the vertical axes represent absorption intensity and emission intensity. Note that the absorption intensity is shown in FIG. 33 using the results obtained in such a way that the absorbance measured by putting only dichloromethane in a quartz cell was subtracted from the absorbance measured by putting the dichloromethane solution (0.0100 mmol/L) in a quartz cell. (0434) As shown in FIG. 33, the organometallic complex [fac-Ir(iPrCzpim)2(iPrpim)] has emission peaks at 479 nm and 514 nm, and blue-green light emission was observed from the dichloromethane solution. (0435) Next, [fac-Ir(iPrCzpim)2(iPrpim)] obtained in this example was analyzed by liquid chromatography-mass spectrometry (LC-MS). (0436) In the analysis by LC-MS, liquid chromatography (LC) separation was carried out with UltiMate 3000 produced by Thermo Fisher Scientific K.K., and the MS analysis was carried out with Q Exactive produced by Thermo Fisher Scientific K.K. (0437) In the LC separation, a given column was used at a column temperature of 40 C., and solution sending was performed in such a manner that an appropriate solvent was selected, the sample w…

According to the analysis of related databases, 914306-50-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Semiconductor Energy Laboratory Co., Ltd.; TSUNOI, Toshiaki; INOUE, Hideko; ISHISONE, Takahiro; WATABE, Takeyoshi; (129 pag.)US2017/213989; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 914306-50-6

A 50 mL Schlenk tube flask was charged with iV-(2,6-diisopropyl phenyl)-2- phenylimidazole (7.60 g, 25 mmol), tris(acetylacetonate)iridium(III) (2.45 g, 5.0 mmol) and tridecane (1 mL). The reaction mixture was stirred under a nitrogen atmosphere and heated at 240 0C for 48 hours. After cooling, the solidified mixture was washed first with absolute ethanol followed by hexane. The residue was further purified by a silica gel column to give EPO fac-vacbeta (1.5 g). The product was further purified by vacuum sublimation. 1H and MS results confirmed the desired compound. lambdamax of emission = 476, 504 nm (CH2Cl2 solution at room temperature), CIE = (0.22, 0.43).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 914306-50-6.

Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; WO2006/121811; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 914306-50-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 914306-50-6 name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3: Synthesis of (OC-6-21)-bis{5-(9H-carbazol-9-yl)-2-[1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl-kappaN3]phenyl-kappaC}{2-[1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl-kappaN3]phenyl-kappaC}iridium(I II) (abbreviation: [mer-Ir(iPrCzpim)2(iPrpim)]) (0417) Into a 100-mL three-neck flask were put 2.8 g (2.3 mmol) of [Ir(iPrCzpim)2(acac)] (abbreviation) obtained in Step 2, 1 g (3.3 mmol) of 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole (abbreviation: HiPrpim), and 20 mL of glycerol, and the mixture was heated and stirred at 150 C. for 12 hours. After reaction for the predetermined time, the reaction solution was filtered and a precipitate was washed with methanol to give a yellow solid. This yellow solid was recrystallized with tetrahydrofuran (THF) to give a yellow solid. The yield was 2.1 g (1.5 mmol) and 64%. Purification by a train sublimation method was performed on 1.0 g of this yellow solid, so that 790 mg (0.52 mmol) of a yellow solid was obtained. The synthesis scheme of Step 3 is shown in (b-3). (0418) Protons (1H) of the yellow solid obtained through Step 3 described above were measured by nuclear magnetic resonance (NMR). The obtained values are shown below. The 1H-NMR chart is shown in FIG. 29. The results revealed that [mer-Ir(iPrCzpim)2(iPrpim)], which is the organometallic complex represented by Structural Formula (600), was obtained in Synthesis Example 2. (0419) 1H-NMR. delta (CD2Cl2): 0.26 (dd, 6H), 0.32 (d, 6H), 1.00 (m, 18H), 1.13 (d, 3H), 1.26 (d, 3H), 2.10 (m, 2H), 2.23 (m, 1H), 2.38 (m, 2H), 2.86 (m, 1H), 6.25 (dd, 2H), 6.32 (d, 1H), 6.48 (d, 1H), 6.56 (m, 2H), 6.63 (dd, 1H), 6.69 (dd, 1H), 6.70 (d, 1H), 6.76 (d, 1H), 6.84 (m, 2H), 6.88 (d, 1H), 7.07 (d, 1H), 7.16 (m, 8H), 7.28 (m, 8H), 7.41 (m, 6H), 7.56 (t, 1), 8.06 (dd, 4H). (0420) Next, an ultraviolet-visible absorption spectrum (absorption spectrum) and an emission spectrum of a dichloromethane solution of [mer-Ir(iPrCzpim)2(iPrpim)] were measured. The measurement of the absorption spectrum was conducted at room temperature, for which an ultraviolet and visible spectrophotometer (V550 type manufactured by JASCO Corporation) was used and the dichloromethane solution (0.0100 mmol/L) was put in a quartz cell. In addition, the measurement of the emission spectrum was performed at room temperature in such a manner that an absolute PL quantum yield measurement system (C11347-01 manufactured by Hamamatsu Photonics K.K.) was used and the deoxidized dichloromethane solution (0.0100 mmol/L) was sealed in a quartz cell under a nitrogen atmosphere in a glove box (LABstar M13 (1250/780) manufactured by Bright Co., Ltd.). Measurement results of the obtained absorption and emission spectra are shown in FIG. 30, in which the horizontal axis represents wavelength and the vertical axes represent absorption intensity and emission intensity. Note that the absorption intensity is shown in FIG. 30 using the results obtained in such a way that the absorbance measured by putting only dichloromethane in a quartz cell was subtracted from the absorbance measured by putting the dichloromethane solution (0.0100 mmol/L) in a quartz cell. (0421) As shown in FIG. 30, the organometallic complex [mer-Ir(iPrCzpim)2(iPrpim)] has emission peaks at 481 nm and 515 nm, and blue-green light emission was observed from the dichloromethane solution. (0422) Next, [mer-Ir(iPrCzpim)2(iPrpim)] obtained in this example was analyzed by liquid chromatography-mass spectrometry (LC-MS). (0423) In the analysis by LC-MS, liquid chromatography (LC) separation was carried out with UltiMate 3000 produced by Thermo Fisher Scientific K.K., and the MS analysis was carried out with Q Exactive produced by Thermo Fisher Scientific K.K. (0424) In the LC separation, a given column was used at a column temperature of 40 C., and solution sending was performed in such a manner that an appropriate solvent was selected, the sample was prepared by dissolving [mer-Ir(iPrCzpim)2(iPrpim)] in an organic solvent at an arbitrary concentration, and the injection amount was 5.0 muL. (0425) A component with m/z of 1432.64, which is an ion derived from [mer-Ir(iPrCzpim)2(iPrpim)], was subjected to the MS2 analysis by a Targeted-MS2 method. For the Targeted-MS2 analysis, the mass range of a target ion was set to m/z=1432.64±2.0 (isolation window=4) and detection was performed in a positive mode. Measurement was performed with energy (normalized collision energy: NCE) for accelerating a target ion in a collision cell set to 30. The obtained MS spectrum is shown in FIG. 31. (0426) FIG. 31 shows that product ions of [mer-Ir(iPrCzpim)2(iPrpim)] are mainly detected around m/z=1129 and m/z=964. The results in FIG. 31 show characteristics derived from [mer-Ir(iPrCzpim)2(iPrpim)] and therefore can be regarded as important data for identifying [mer-Ir(iPrCzpim)2(iPrpim)] contained in a mixture. (0427) It is presumed that the product ion around m/z=1129 is a cation in a state where the ligand HiPrpim (abbreviation) is …

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Patent; Semiconductor Energy Laboratory Co., Ltd.; TSUNOI, Toshiaki; INOUE, Hideko; ISHISONE, Takahiro; WATABE, Takeyoshi; (129 pag.)US2017/213989; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C21H24N2

xample 8[0146] To a round-bottom flask was added l-(2,6-diisopropylphenyl)-2-phenyl- lH-imidazole (8.00 g, 26.3 mmol) and iridium(III) chloride hydrate (3.09 g, 8.76 mmol) with 2-ethoxyethanol (90 mL) and water (30 mL) under N2 atmosphere. The resulting reaction mixture was refluxed at 130 C for 18 h. The green precipitate was filtered, washed with ethanol (3 – 4 times) and hexane (3 – 4 times) to yield 7.3 g (98.9%) of a green solid after drying. The product was used without further purification.

According to the analysis of related databases, 914306-50-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; KOTTAS, Gregg; XIA, Chuanjun; ELSHENAWY, Zeinab; ANSARI, Narin; WO2012/158851; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 914306-50-6

1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole (2) (14.77 g, 48.5 mmol) was dissolved in DMF (200 ml) and NB S (9.50 g, 53.4 mmol) was added and the mixture was stirred at room temperature for 48 hours. More NBS (8.63 g, 48.5 mmol) was added and the reaction was stirred in a 70 C. oil bath for another 24 hours. Solvents were removed by kugelrohr and the residue was partitioned between EtOAc and water, filtering through a frit to remove black insoluble materials. The aqueous layer was extracted twice more with EtOAc, the organics were washed with water and brine, dried and purified by column chromatography to yield 3 as a colorless solid, 18.27 (81%).

The synthetic route of 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Universal Display Corporation; Szigethy, Geza; (140 pag.)US2018/319830; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem