Tag: M.W=300-400

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 914306-50-6

A 50 mL Schlenk tube flask was charged with N-(2,6-diisopropyl phenyl)-2- phenylimidazole (7.60 g, 25 mmol), tris(acetylacetonate)iridium(III) (2.45 g, 5.0 mmol) and tridecane (1 mL). The reaction mixture was stirred under a nitrogen atmosphere and heated at EPO 240 C for 48 hours. After cooling, the solidified mixture was washed first with absolute ethanol followed by hexane. The residue was further purified by a silica gel column to give fac-mc6 (1.5 g). The product was further purified by vacuum sublimation. 1H and MS results confirmed the desired compound. lambdamax of emission = 476, 504 nm (CH2Cl2 solution at room temperature), CIE = (0.22, 0.43).

The synthetic route of 914306-50-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; WO2008/54584; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 53525-60-3, name is Ethyl 1-trityl-1H-imidazole-4-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53525-60-3, name: Ethyl 1-trityl-1H-imidazole-4-carboxylate

To a stirred solution of acetonitrile (0.32 g; 7.80 mmol) in tetrahydrofuran (20 ml) was addedsodium bis(trimethylsilyl)amide (15.7m1, 1.OM in THF, 15.69 mmol at 0C. The stirring wascontinued for 30 minutes and then a solution of ethyl 1 -trityl- 1 H-imidazole-4-carboxylate (XLV; 2 g; 5.23 mmol) in THF (20 ml) was added. The reaction mixture was stirred at 80C for 12 h. The reaction mixture was cooled, concentrated at reduced pressure and diluted with ice cold water. The aqueous layer was extracted with ethyl acetate, and the resulting organiclayer washed with brine, dried over Na2504, filtered and concentrated under vacuum to afford3-oxo-3-(1-trityl-1H-imidazol-4-yl)propanenitrile as a brown solid (XLVI; 1 g, 50% yield). MS (M+1) 378.34.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1-trityl-1H-imidazole-4-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; NORGINE B.V.; BAKTHAVATCHALAM, Rajagopal; BASU, Manas Kumar; BEHERA, Ajit Kumar; VENKATESHAPPA, Chandregowda; HEWSON, Christopher Alexander; KADNUR, Sanjay Venkatachalapathi; KALINDJIAN, Sarkis Barret; KULKARNI, Bheemashankar; SAXENA, Rohit; SURESH, Juluri; VISWANATHAN, Vellarkad; ZAINUDDIN, Mohd; DHARSHINIS, Akila Parvathy; KRISTAM, Rajenda; WO2015/97122; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 31250-80-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31250-80-3, name is 1-Benzyl-2,4,5-tribromo-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: PdCl2(dppf), PdCl2(tbpf) and (A.caPhos)PdCl2. A mixture of the halogenated heterocycle (0.66 mmol) in anhydrous THF (13.2 mL) was degassed by bubbling argon for few minutes. Then, PdCl2(dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv) and finally NaBH4 (42.4 mg, 1.12 mmol, 1.7 equiv) were introduced in sequence. The mixture was stirred at room temperature under argon for the proper time and then worked up as described above.

The synthetic route of 1-Benzyl-2,4,5-tribromo-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chelucci, Giorgio; Figus, Susanna; Journal of Molecular Catalysis A: Chemical; vol. 393; (2014); p. 191 – 209;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 53525-60-3, name is Ethyl 1-trityl-1H-imidazole-4-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53525-60-3, Recommanded Product: Ethyl 1-trityl-1H-imidazole-4-carboxylate

Add 600 mL Methanol and 650 ml tetrahydrofuran to a 5 L dried four-mouth bottle equipped with a mechanical stirring and a thermometer, then add 125 g (0.327mol, 1.0 eq) 1-trityl -1H-imidazole-4-ethyl formate; stir to form a suspension; 1 L sodium hydroxide solution (2M, 6 eq) is dropped into the suspension, wherein the temperature is controlled to be 1020 C. Stir for 5 hrs and then the reaction ends. 1 L Hydrochloric acid solution (2M) is slowly dropped and a great amount of white solids are generated when the mixed solution is stirred. Adjust pH value to 56. Filter and dry to obtain 112 g 1-trityl-1H-imidazole-4-formic acid, with a yield of 96% and a purity of 97% (HPLC).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; TIANJIN WEIJIE PHARMACEUTICAL CO., LTD; SONG, Honghai; SUN, Zhicun; HUANG, Haiping; ZHANG, Chao; (5 pag.)US2016/272594; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 914306-50-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.

3.50 g (11.5 mmol) of 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole are initially charged in 200 ml of 2-ethoxyethanol/water (ratio 3/1) and admixed with 1.84 g (5.2 mmol) of iridium(III) chloride trihydrate. The reaction mixture is heated at reflux for 18 h. After cooling, 50 ml of distilled water are added. The precipitate is filtered off, washed with distilled water and dried. This gives 3.50 g (80%) of ?-dichloro dimer D1 as a yellow powder. 1H NMR (CD2Cl2, 400 MHz):delta=0.95 (d, 12H), 1.18 (d, 12H), 1.27 (d, 12H), 1.34 (d, 12H), 2.80-2.91 (m, 8H), 6.08 (d, 4H), 6.24 (d, 4H), 6.39 (pt, 4H), 6.53 (pt, 4H), 6.97 (d, 4H), 7.39-7.45 (m, 8H), 7.59 (t, 4H), 7.67 (d, 4H).

The chemical industry reduces the impact on the environment during synthesis 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole. I believe this compound will play a more active role in future production and life.

50257-40-4, name is 1-((2,4,6-Triisopropylphenyl)sulfonyl)-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 50257-40-4

To a stirred suspension of NaH (60percent in oil dispersion) (2.9 g, 72 mmol) in dry THF (200 mL) at 0C was added in portions 16 (2.5 g, 15.8 mmol), followed by 2,4,6-triisopropyl-benzenesulfonylimidazole (13 g, 39.6 mmol), and the whole mixture was then stirred for 3 h. Cold H2O (80 mL) was added, and the resulting mixture was extracted with EtOAc (3 × 50 mL). The combined extracts were washed with brine (50 mL) and then dried (anhydrous Na2SO4). Evaporation of the solvent gave the crude product, which was purified by flash chromatography on silica gel (hexane/EtOAc, 50:1) to afford 17 (2.5 g, 42percent yield) as colorless oil. [alpha]D20 -2.0 (c = 1.00, CH2Cl2); 96percent ee; 1H NMR (300 MHz, CDCl3): delta 1.04 (t, J = 7.5 Hz, 3 H), 1.22-1.28 (m, 18 H), 2.02-2.07 (m, 2 H), 2.62-2.68 (m, 2 H), 2.81 (dd, J = 2.5, 4.8 Hz, 1 H), 2.90-2.93 (m, 2 H), 3.22-3.25 (m, 1 H), 4.12-4.16 (m, 2 H), 4.50-4.55 (m, 1 H), 7.18 (s, 2 H); 13C NMR (75 MHz, CDCl3): delta 12.4, 13.9, 22.9, 23.6, 24.7, 24.8, 29.8, 34.3, 45.5, 52.5, 72.9, 79.4, 85.2, 123.8, 130.7, 150.6, 153.7; HRMS (ESI): m/z [M+Na]+ calcd for C23H34O4SNa: 429.2070; found: 429.2073.

The synthetic route of 50257-40-4 has been constantly updated, and we look forward to future research findings.

Related Products of 33016-47-6, A common heterocyclic compound, 33016-47-6, name is 1-Trityl-1H-imidazole-4-carbaldehyde, molecular formula is C23H18N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 100 ml, three-necked flask fitted with a magnetic stirrer, under inert atmosphere, ethyl iodide (1.1 ml, 0.0136 mol) is dissolved in Et2theta (25 ml). At -70 0C, a1.5 M solution of t-BuLi in pentane (17 ml, 0.026 mol) is added dropwise. The mixture is stirred 0.3 h at this temperature and 0.75 h at room temperature. A solution of 1-trityl-1 H- imidazole-4-carbaldehyde x43 (2 g, 0.00591 mole) in THF (25 ml) is added dropwise at 0 0C. The mixture is stirred for 1 h and poured onto ice. HCI is added until the pH is slightly acid (pH : 3-5) and the aqueous phase is extracted twice with Et^O. The combined organic phases are dried over MgSOphi filtered and concentrated to dryness. The crude product is purified by chromatography on silicagel (CH2Cl2/MeOH/NH4thetaH: 95/4.5/0.5 (v/v/v)) to afford 1.21 g of 1-(1-trityl-1H-imidazol-4-yl)propan-1-ol x88. Yield: 56 %.LC-MS (MH+): 369.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 103057-10-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103057-10-9 as follows.

1.1 triphenyl[[(1-triphenylmethyl)-1H-imidazol-4-yl]methyl]phosphonium chloride 77.7 g (296 mmoles) of triphenylphosphine was added to a solution of 105.5 g (294 mmoles) of 4-(chloromethyl)-1-(triphenylmethyl)-1H-imidazole in 670 ml of dimethylformamide. The resulting mixture was heated at 80 C. for three hours before being allowed to cool to room temperature. The solvent then was evaporated and the crude residue taken up in ether and triturated. The precipitate was filtered and dried under vacuum over phosphorus pentoxide to provide 162 g of the title compound in the form of yellowish crystals. Melting point=210 C. Yield=89%

According to the analysis of related databases, 103057-10-9, the application of this compound in the production field has become more and more popular.

Related Products of 87941-55-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87941-55-7, name is 4-Bromo-1-trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of (3-(hydroxymethyl)phenyl)boronic acid (58.6 mg, 0.3 85 mmol),4-bromo-1-trityl-1H-immdazole (100 mg, 0.257 mmol), PdC12(dppf)-DCM adduct (10 mg,0.013 mmol) and potassium carbonate (178 mg, 1.28 mmol) in 1,4-dioxane (2 mL) and water (0.5 mL) was sparged 3 times with Ar. The reaction mixture then was heated at 150C in a microwave for 30 mm. The mixture was partitioned between DCM and water. The organic layer was washed with brine. The combined aqueous layers were extracted withDCM. The combined organics were dried with Na2SO4, filtered, and concentrated. The crude was purified by flash chromatography to give 278A (89 mg, 83%) as a white solid.MS(ESI) m/z 417.2 (M+H).

The synthetic route of 4-Bromo-1-trityl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Electric Literature of 152628-02-9,Some common heterocyclic compound, 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a container equipped with a thermometer, a stirrer, and a condenser, 2-n-propyl-4-methyl-6- (1?-methylbenzimidazol-2-yl) benzimidazole (purity 94.4%) 30. 0 part by weight and 124 parts by weight of N-methyl-2-pyrrolidone were charged and dissolved at 20-25 C. with stirring. Next, 11.1 parts by weight of t-butoxypotassium was charged at 20-30 C. over about 30 minutes, and then cooled to 2-5 C.In this mixed solution, 124 parts by weight of N-methyl-2-pyrrolidone and 33.1 parts by weight of 4?-bromomethylbiphenyl-2-carboxylic acid methyl ester were charged and dissolved at 15 to 20 C. with stirring. The total amount of 157.1 parts by weight of N-methyl-2-pyrrolidone solution containing 4?-bromomethylbiphenyl-2-carboxylic acid methyl ester was added dropwise over a period of 30 minutes in the range of 2 to 5 C. The mixture was kept at the same temperature for about 3 hours to obtain a reaction mixture of telmisartan methyl ester (I). Thereafter, the mixture is heated to about 55 C., and then 211 parts by weight of water is added dropwise in the range of 50 to 55 C. over about 1 hour to precipitate crystals, and then kept at the same temperature for 3 hours. The solution was cooled to 0 C., filtered, washed with methanol water, and dried at 50 C./1 kPa to obtain 42.8 parts by weight of telmisartan methyl ester (I) crystals. The crystals were analyzed by liquid chromatography.

The synthetic route of 152628-02-9 has been constantly updated, and we look forward to future research findings.