Tag: M.W=400-450

Das, Rajesh published the artcileStrategic design of a bifunctional Ag(I)-grafted NHC-MOF for efficient chemical fixation of CO₂ from a dilute gas under ambient conditions, Synthetic Route of 258278-25-0, the publication is Inorganic Chemistry Frontiers (2022), 9(11), 2583-2593, database is CAplus.

The chem. fixation of carbon dioxide into valuable products constitutes a promising step toward reducing the atm. CO₂ concentration Consequently, herein we report the strategic design of a bifunctional catalyst by grafting catalytically active Ag(I) ions onto N-heterocyclic carbene (NHC) sites in a MOF for efficient chem. fixation of CO₂ from a dilute gas to oxazolidinones, bio-relevant commodity chems. Indeed, Ag(I)@MOF-NHC demonstrated excellent catalytic activity for efficient fixation of CO₂ from a dilute gas (CO₂ : N₂ = 13 : 87%) with alkynes to afford valuable chems., oxazolidinones, under RT and atm. pressure (balloon) conditions. The superior activity of the Ag(I) anchored MOF over the individual (AgNO₃ and MOF-NHC) components has been ascribed to the synergistic effect between the CO₂-philic NHC and alkynophilic Ag(I) sites exposed in the 1D channels of the MOF. Furthermore, the Ag(I) anchored MOF showed high recyclability without significant loss of catalytic activity and structural rigidity. Overall, this is a unique demonstration of the utilization of dilute CO₂ under environmentally friendly mild conditions and can pave the way for the development of efficient catalytic systems for sustainable utilization of CO₂ from dilute gases.

Inorganic Chemistry Frontiers published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Synthetic Route of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Park, Tae Jung published the artcileAlignment of SWNTs by protein-ligand interaction of functionalized magnetic particles under low magnetic fields, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Journal of Nanoscience and Nanotechnology (2011), 11(5), 4540-4545, database is CAplus and MEDLINE.

A simple method to controllably align single-walled CNTs (SWNTs) by magnetic particles embedded with superparamagnetic iron oxide as an accelerator under the magnetic field was developed. The functionalization of SWNTs using biotin, interacted with streptavidin-coupled magnetic particles (micro-to-nano in diameter), and layer-by-layer assembly were performed for the alignment of a particular direction onto the clean Si and the Au substrate at very low magnetic forces (0.02-0.89 T) at room temperature The successful alignment of the SWNTs with multi-layer film was observed by SEM and TEM. By changing the orientation and location of the substrates, crossed-networks of SWNTs-magnetic particle complex could easily be fabricated. It is suggested that this approach, which consists of a combination of biol. interaction among streptavidin-biotin and magnetite particles, should be useful for lateral orientation of individual SWNTs with controllable direction.

Journal of Nanoscience and Nanotechnology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sung, Daekyung published the artcileFacile Method for Selective Immobilization of Biomolecules on Plastic Surfaces, HPLC of Formula: 359860-27-8, the publication is Langmuir (2009), 25(19), 11289-11294, database is CAplus and MEDLINE.

A key aspect of biochip and biosensor preparation is optimizing surface attachment of biomols. Here, the authors report a facile approach for selectively immobilizing biomols. on amphiphilic polymer-coated plastic surfaces with anti-biofouling properties. To modify plastic surfaces, the authors synthesized two types of random copolymers by radical polymerization, which consisted of three parts: an anchoring group; a PEG component, which acted as a repellent of nonspecific biomols.; and a functional group, to which biomols. were conjugated. Dodecyl- and benzyl-based copolymers were highly soluble in water, presumably due to the presence of multiple PEG groups, and could easily coat the model plastic surface (polystyrene) in an aqueous environment. The antibiofouling property of each polymer-coated plastic surface was examined by measuring the extent of nonspecific protein adsorption using bovine serum albumin (BSA). Both polymer-coated plastic surfaces showed a very low level of BSA adsorption relative to that of an uncoated plastic surface (control). Finally, the authors showed that streptavidin and antibodies, as representative biomols., could be selectively immobilized on the polymer-coated plastic surfaces imprinted with biotin and protein A, resp., by microcontact printing, exhibiting an intense signal with low background.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C9H11BO4, HPLC of Formula: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Asano, Shigehiro published the artcileSite-selective labeling of a lysine residue in human serum albumin, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Angewandte Chemie, International Edition (2014), 53(44), 11783-11786, database is CAplus and MEDLINE.

Conjugation to human serum albumin (HSA) has emerged as a powerful approach for extending the in vivo half-life of many small mol. and peptide/protein drugs. Current HSA conjugation strategies, however, can often yield heterogeneous mixtures with inadequate pharmacokinetics, low efficacies, and variable safety profiles. Here, we designed and synthesized analogs of TAK-242, a small mol. inhibitor of Toll-like receptor 4, that primarily reacted with a single lysine residue of HSA. These TAK-242-based cyclohexene compounds demonstrated robust reactivity, and Lys64 was identified as the primary conjugation site. A bivalent HSA conjugate was also prepared in a site-specific manner. Addnl., HSA-cyclohexene conjugates maintained higher levels of stability both in human plasma and in mice than the corresponding maleimide conjugates. This new conjugation strategy promises to broadly enhance the performance of HSA conjugates for numerous applications.

Angewandte Chemie, International Edition published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Aslan, Kadir published the artcileQuenched Emission of Fluorescence by Ligand Functionalized Gold Nanoparticles, COA of Formula: C18H34N4O5S, the publication is Journal of Fluorescence (2004), 14(4), 401-405, database is CAplus and MEDLINE.

A fluorescence-based detection scheme that uses ligand functionalized Au nanoparticles is proposed. The transduction scheme is based on the strong quenching of the fluorescence emission exerted by metallic surfaces on fluorophores positioned in their immediate vicinity (<5 nm). Binding of fluorophore-labeled antibiotin to biotinylated Au nanoparticles resulted in decreased fluorescence emission intensity. Subsequent competitive dissociation of labeled antibiotin with D-biotin resulted in increased fluorescence emission intensity. These interactions occurred by specific mol. recognition because when the binding sites of antibiotin were saturated with D-biotin prior to interaction with the Au nanoparticles; changes in the fluorescence emission intensity were not observed

Journal of Fluorescence published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, COA of Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Sunmook published the artcileDextran-Gold Nanoparticle Hybrid Material for Biomolecule Immobilization and Detection, HPLC of Formula: 359860-27-8, the publication is Analytical Chemistry (2005), 77(22), 7204-7211, database is CAplus and MEDLINE.

The formation of a hybrid metal-biopolymer material is described. The synthesis of this material consists of functionalizing the surface of gold nanoparticles through a series of steps that lead to epoxy-functionalized nanoparticles. These are subsequently reacted with hydroxyl moieties of the α-D-glucopyranosyl groups of dextran. Subsequently, the dextran chains are carboxylated through treatment with bromoacetic acid. The resultant material combines the unique optical properties of gold nanoparticles with the versatility that carboxylated dextran offers for further functionalization with biomols. The interaction of this material with three proteins was then investigated through changes in the plasmon resonance properties of the gold nanoparticles. Con A, a lectin that binds glucose and mannose by specific mol. recognition, interacts readily with this material and such interaction is easily detected using optical absorption spectroscopy. Through reaction of the carboxyl groups with (+)-biotinyl-3,6,9,-trioxaundecanediamine, a material bearing biotin groups was obtained. This could interact with streptavidin or antibiotin by specific mol. recognition. Further confirmation of biospecific interactions was obtained with control experiments in which the binding sites were blocked through preincubation of the proteins with the corresponding ligand in solution Binding of these proteins was concentration-dependent over a wide concentration range. This material provides a simple and convenient colorimetric method for biospecific interaction anal.

Analytical Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, HPLC of Formula: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Scattolin, Thomas published the artcileIndenyl and Allyl Palladate Complexes Bearing N-Heterocyclic Carbene Ligands: an Easily Accessible Class of New Anticancer Drug Candidates, Synthetic Route of 258278-25-0, the publication is European Journal of Inorganic Chemistry (2022), 2022(16), e202200103, database is CAplus.

The mechanochem. syntheses of allyl and indenyl palladate complexes are reported. All compounds were obtained in quant. yields and microanalytically pure without the need of any workup. These complexes are stable in chlorinated and polar (DMSO or DMSO/H₂O solutions) solvents. In chlorinated solvents, they appear as ionic pairs of which crystals suitable for single x-ray diffraction studies have been obtained. Bonding and solvation properties are rationalized through scalar relativistic DFT calculations Moreover, most complexes showed excellent cytotoxicity towards ovarian cancer cell lines, with IC₅₀ values comparable or lower than cisplatin. The potent anticancer activity of two IPr^Cl and IPr*-based palladate complexes was examined in a high-grade serous ovarian cancer (HGSOC) patient-derived tumoroid. Moreover, the inhibition of the antioxidant enzyme thioredoxin reductase (TrxR) was noticed, and structure-activity relationships could be derived, suggesting the ROS detoxifying system is involved in the mode of action.

European Journal of Inorganic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Synthetic Route of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pavli, P. published the artcileChemical binding of biomolecules to micropatterned epoxy modified surfaces for biosensing applications, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Microelectronic Engineering (2009), 86(4-6), 1473-1476, database is CAplus.

The formation of micro/nanostructures that can be used for binding of specific biomols. is of great importance for the development of multi-analyte biosensing devices and high-throughput microarrays. In this paper, we report on the chem. binding of biotin on an epoxy photolithog. patterned surface. In particular, we used a neg. chem. amplified epoxy resist (EPR) in order to create very small structures by photolithog., in which biotin derivatives functionalized with succinimidyl ester or an amine group were immobilized through covalent bonding. Lithog. process with exposure at 248 nm was optimized, and structures with diameter down to 0.5 μm were demonstrated, where biomols. were successfully bound.

Microelectronic Engineering published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Monsigny, Louis published the artcileActivated Hoveyda-Grubbs Olefin Metathesis Catalysts Derived from a Large Scale Produced Pharmaceutical Intermediate – Sildenafil Aldehyde, Application of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Advanced Synthesis & Catalysis (2021), 363(19), 4590-4604, database is CAplus.

Two EWG-activated Hoveyda-Grubbs-type ruthenium complexes (Sil-II and Sil-II’) were obtained, characterized, and screened in a set of olefin metathesis reactions. These catalysts were conveniently synthesized from a com. available pharmaceutical building block – Sildenafil aldehyde – in two steps only. Stability and catalytic activity tests disclosed that the bulkier NHC-ligand bearing catalyst Sil-II’ is visibly more stable and productive than its smaller NHC-analog Sil-II. Good application profile of catalyst Sil-II’ was confirmed in a set of diverse metathesis reactions including ring-closing metathesis (RCM) and cross-metathesis (CM) of complex polyfunctional substrates of medicinal chem. interest, including a challenging macrocyclization of the Pacritinib precursor. Compatibility of the new catalyst with various green solvents was checked and metathesis of Sildenafil and Tadalafil-based substrates was successfully conducted in acetone. The mechanism of Sil-II’ initiation has been investigated through kinetic experiments unveiling that the decrease of the steric hindrance of the chelating alkoxy moiety (from iPrO to EtO) favors the interchange initiation pathway over the typical dissociation pathway for other popular 2^nd generation Hoveyda-Grubbs catalysts.

Advanced Synthesis & Catalysis published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Application of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jankowska-Anyszka, Marzena published the artcileSynthesis of a new class of ribose functionalized dinucleotide cap analogs for biophysical studies on interaction of cap-binding proteins with the 5′ end of mRNA, Synthetic Route of 359860-27-8, the publication is Organic & Biomolecular Chemistry (2011), 9(15), 5564-5572, database is CAplus and MEDLINE.

MRNAs of primitive eukaryotes such as Caenorhabditis elegans and Ascaris summ possess two different caps at their 5′ terminus. They have either a typical cap which consists of 7-methylguanosine linked via a 5′,5′-triphosphate bridge to the first transcribed nucleotide (MMG cap) or an atypical hypermethylated form with two addnl. Me groups at the N2 position (TMG cap). Studies on interaction between the 5′ end of mRNA and proteins that specifically recognize its structure have been carried out for several years and they often require chem. modified cap analogs. Here, we present the synthesis of five novel dinucleotide MMG and TMG cap analogs designed for binding studies using biophys. methods such as ESR and surface plasmon resonance. New analogs were prepared by derivatization of the 2′,3′-cis diol of the second nucleotide in the cap structure with levulinic acid, and coupling of the obtained acetal through its carboxylic group with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino TEMPO), ethylenediamine (EDA) or (+)-biotinyl-3,6,9-trioxaundecanediamine (amine-PEO₃-biotin).

Organic & Biomolecular Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem