Tag: M.W=400-450

Gibard, Clementine published the artcileAccess to silver-NHC complexes from soluble silver species in aqueous or ethanolic ammonia, COA of Formula: C27H39ClN2, the publication is Journal of Organometallic Chemistry (2017), 70-74, database is CAplus.

In this communication, we report the use of aqueous ammonia as original conditions for the metalation of imidazol(in)ium ligands. This reaction, performed in homogeneous conditions via a soluble silver-ammine complex is a rapid, scalable and often efficient access to silver-NHC complexes. Moreover, modification of the reported reaction conditions allowed the preparation of unprecedented heteroleptic NHC-Ag-phosphine in case of bulky IPr and SIPr ligands.

Journal of Organometallic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, COA of Formula: C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jonsson, Helgi Freyr published the artcileRapid and mild synthesis of Au-NHC complexes in a simple two-phase flow reactor, Application In Synthesis of 258278-25-0, the publication is Dalton Transactions (2021), 50(23), 7969-7975, database is CAplus and MEDLINE.

We describe a simple two-phase flow reactor which allows for the rapid synthesis of several Au(I)-NHC complexes in high yields (>88%), under mild conditions, and with minimal workup. Translation of the standard weak base method to a two-phase flow reaction prevents the common problem of decomposition to Au(0). The reaction can be scaled up more than ten-fold without loss in conversion efficiency. An optional second stage allows for direct synthesis of Au(III)-NHC complexes, without isolation of the Au(I)-NHC intermediate, with a two-step isolated yield of 82%.

Dalton Transactions published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Application In Synthesis of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Munoz, Salvador B. published the artcileCombined Effects of Backbone and N-Substituents on Structure, Bonding, and Reactivity of Alkylated Iron(II)-NHCs, Related Products of imidazoles-derivatives, the publication is Organometallics (2018), 37(18), 3093-3101, database is CAplus and MEDLINE.

Iron and N-heterocyclic carbenes (NHCs) have proven to be a successful pair in catalysis, with reactivity and selectivity being highly dependent on the nature of the NHC ligand backbone saturation and N-substituents. Four (NHC)Fe(1,3-dioxan-2-ylethyl)₂ complexes have been isolated and spectroscopically characterized to correlate their reactivity to steric effects of the NHC from both the backbone saturation and N-substituents. Only in the extreme case of SIPr where NHC backbone and N-substituent steric effects are the largest is there a major structural perturbation observed crystallog. The addition of only two hydrogen atoms is sufficient for a drastic change in product selectivity in the coupling of 1-iodo-3-phenylpropane with (2-(1,3-dioxan-2-yl)ethyl)magnesium bromide due to resulting structural perturbations to the precatalyst. Mossbauer spectroscopy and magnetic CD enabled the correlation of covalency and steric bulk in the SIPr case to its poor selectivity in alkyl-alkyl cross-coupling with iron. D. functional theory calculations provided insight into the electronic structure and MO effects of ligation changes to the iron center. Finally, charge donation anal. and Mayer bond order calculations further confirmed the stronger Fe-ligand bonding in the SIPr complex. Overall, these studies highlight the importance of considering both N-substituent and backbone steric contributions to structure, bonding, and reactivity in iron-NHCs.

Organometallics published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Balmer, Markus published the artcileLow-Valent Group 14 Phosphinidenide Complexes [({SIDipp}P)₂M] Exhibit P-M pπ-pπ Interaction (M=Ge, Sn, Pb), Application of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Chemistry – A European Journal (2020), 26(1), 192-197, database is CAplus and MEDLINE.

Herein, the synthesis of new low-valent Group 14 phosphinidenide complexes [({SIDipp}P)₂M] exhibiting P-M pπ-pπ interactions (SIDipp = 1,3-bis(2,6-diisopropylphenyl)-imidazolidin-2-ylidene, M = Ge, Sn, Pb), is presented. These compounds were studied by structural, spectroscopic, and quantum-chem. methods. Furthermore, the monosubstituted compounds [(SIDippP)MX]₂ (M = Sn, X=Cl; M = Pb, X = Br) are presented, which show dimeric structures instead of multiple bonding interaction.

Chemistry – A European Journal published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Application of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kim, Younggyu published the artcileNonradioactive, ultrasensitive site-specific protein-protein photocrosslinking: interactions of α-helix 2 of TATA-binding protein with general transcription factor TFIIA and transcriptional repressor NC2, Computed Properties of 359860-27-8, the publication is Nucleic Acids Research (2008), 36(19), 6143-6154, database is CAplus and MEDLINE.

The authors have developed an approach that enables nonradioactive, ultrasensitive (attamole sensitivity) site-specific protein-protein photocrosslinking, and we have applied the approach to the anal. of interactions of α-helix 2 (H2) of human TATA-element binding protein (TBP) with general transcription factor TFIIA and transcriptional repressor NC2. TBP H2 can be crosslinked to TFIIA in the TFIIA-TBP-DNA complex and in higher order transcription-initiation complexes, and the crosslink was mapped to the ‘connector’ region of the TFIIA α/β subunit (TFIIAα/β). Furthermore, TBP H2 can be crosslinked to NC2 in the NC2-TBP-DNA complex, and the crosslink was mapped to the C-terminal ‘tail’ of the NC2 α-subunit (NC2α). Interactions of TBP H2 with the TFIIAα/β connector and the NC2α C-terminal tail were not observed in crystal structures of TFIIA-TBP-DNA and NC2-TBP-DNA complexes, since relevant segments of TFIIA and NC2 were not present in truncated TFIIA and NC2 derivatives used for crystallization The authors propose that interactions of TBP H2 with the TFIIAα/β connector and the NC2α C-terminal tail provide an explanation for genetic results suggesting importance of TBP H2 in TBP-TFIIA interactions and TBP-NC2 interactions, and provide an explanation – steric exclusion – for competition between TFIIA and NC2.

Nucleic Acids Research published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Computed Properties of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Addy, Partha Sarathi published the artcileA Chemoselective Rapid Azo-Coupling Reaction (CRACR) for Unclickable Bioconjugation, Computed Properties of 359860-27-8, the publication is Journal of the American Chemical Society (2017), 139(34), 11670-11673, database is CAplus and MEDLINE.

Chemoselective modification of complex biomols. has become a cornerstone of chem. biol. Despite the exciting developments of the past two decades, the demand for new chemoselective reactions with unique abilities, and those compatible with existing chemistries for concurrent multisite-directed labeling, remains high. Here the authors show that 5-hydroxyindoles exhibit remarkably high reactivity toward aromatic diazonium ions and this reaction can be used to chemoselectively label proteins. The authors have previously genetically encoded the noncanonical amino acid 5-hydroxytryptophan in both E. coli and eukaryotes, enabling efficient site-specific incorporation of 5-hydroxyindole into virtually any protein. The 5-hydroxytryptophan residue was shown to allow rapid, chemoselective protein modification using the azo-coupling reaction, and the utility of this bioconjugation strategy was further illustrated by generating a functional antibody-fluorophore conjugate. Although the resulting azo-linkage is otherwise stable, the authors show that it can be efficiently cleaved upon treatment with dithionite. The work establishes a unique chemoselective “unclickable” bioconjugation strategy to site-specifically modify proteins expressed in both bacteria and eukaryotes.

Journal of the American Chemical Society published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Computed Properties of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem