M.W=400-450 Archives - Page 29 of 35 - Imidazoles-derivatives

Segato, Jacopo team published research in Catalysis Science & Technology in 2020 | 250285-32-6

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride.

Segato, Jacopo;Del Zotto, Alessandro;Belpassi, Leonardo;Belanzoni, Paola;Zuccaccia, Daniele research published 《 Hydration of alkynes catalyzed by [Au(X)(L)(ppy)]X in the green solvent γ-valerolactone under acid-free conditions: the importance of the pre-equilibrium step》, the research content is summarized as follows. [AuCl(NHC)(ppy)]Cl and [AuCl(PPh₃)(ppy)]OTf complexes [ppy = 2-phenylpyridine, NHC = 1,3-bis(2,6-di-isopropylphenyl)-imidazol-2-ylidene] successfully catalyze the hydration of alkynes in γ-valerolactone (GVL), under acid-free conditions. The solution structure, reactivity, and catalytic properties of [AuCl(NHC)(ppy)]Cl and [AuCl(PPh₃)(ppy)]OTf were established by means of multinuclear NMR and computational (DFT) studies. Structural features of [AuCl(NHC)(ppy)]Cl during the catalysis, inferred by NMR spectroscopy, clearly indicate that complex [AuCl(NHC)(ppy)]Cl retains its square planar structure and no reduction to Au(I) and/or Au(0) nanoparticles was observed The overall catalytic and kinetic investigations [kinetic isotopic effect (KIE), effect of acid additives, the order of reaction with respect to the catalyst, alkyne and nucleophile and the effect of the temperature] supported by computational results confirm that the pre-equilibrium step of the reaction mechanism is the RDS: water or counterion substitution by 3-hexyne in the first co-ordination sphere of Au(III) is the key step of the whole process. The description of the mechanism of the hydration of 3-hexyne catalyzed by [AuCl(NHC)(ppy)]Cl here reported appears therefore to be of high significance because comprehensive mechanistic studies of the Au(III)-catalyzed hydration reaction of the CC bond are scarce in the literature and generally lack exptl. basis.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rzhevskiy, Sergey A. team published research in Journal of Organometallic Chemistry in 2020 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. HPLC of Formula: 250285-32-6.

Rzhevskiy, Sergey A.;Topchiy, Maxim A.;Lyssenko, Konstantin A.;Philippova, Anna N.;Belaya, Maria A.;Ageshina, Alexandra A.;Bermeshev, Maxim V.;Nechaev, Mikhail S.;Asachenko, Andrey F. research published 《 New expanded-ring NHC platinum(0) complexes: Synthesis, structure and highly efficient diboration of terminal alkenes》, the research content is summarized as follows. The synthesis and structural characterization of novel Pt(0) complexes are reported. A number of (NHC)Pt(dvtms) (dvtms = 1,3-divinyl-1,1,3,3-tetramethyldisiloxane) complexes were studied in catalytic addition of B₂Pin₂ to terminal alkenes. The novel expanded ring N-heterocyclic carbene complex (7-Dipp)Pt(dvtms) showed highest performance, turnover numbers up to 3800 were achieved. The scope of the reaction was illustrated by 20 examples with a variety of alkyl, alkoxy, halogen, ester, ketone and acetal substituents.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Saab, Marina team published research in Dalton Transactions in | 250285-32-6

Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride.

Saab, Marina;Nelson, David J.;Tzouras, Nikolaos V.;A. C. A. Bayrakdar, Tahani;Nolan, Steven P.;Nahra, Fady;Van Hecke, Kristof research published 《 Straightforward access to chalcogenoureas derived from N-heterocyclic carbenes and their coordination chemistry》, the research content is summarized as follows. Chalcogen-based urea compounds supported by a wide range of N-heterocyclic carbenes were synthesized and fully characterized. Coordination of selenoureas is further explored with Group 11 transition metals to form new copper, gold and silver complexes. Single crystal x-ray analyses unambiguously establish the solid-state coordination of these complexes and show that the geometry of a complex is highly influenced by a combination of electronic properties – mainly π-accepting ability – and steric hindrance of the ligands, as well as the nature of the metal, affording a variety of coordination behaviors. The authors study these phenomena using several exptl. methods.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pein, Wesley L. team published research in Organic Letters in 2021 | 250285-32-6

Computed Properties of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Computed Properties of 250285-32-6.

Pein, Wesley L.;Wiensch, Eric M.;Montgomery, John research published 《 Nickel-Catalyzed Ipso-Borylation of Silyloxyarenes via C-O Bond Activation》, the research content is summarized as follows. The conversion of silyloxyarenes to boronic acid pinacol esters via Ni catalysis is described. In contrast to other borylation protocols of inert C-O bonds, the method is competent in activating the C-O bond of silyloxyarenes in isolated aromatic systems lacking a directing group. The catalytic functionalization of benzyl silyl ethers was also achieved under these conditions. Sequential cross-coupling reactions were achieved by leveraging the orthogonal reactivity of silyloxyarenes, which could then be functionalized subsequently.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Piontek, Aleksandra team published research in ChemCatChem in 2021 | 250285-32-6

Application In Synthesis of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Piontek, Aleksandra;Ochedzan-Siodlak, Wioletta;Bisz, Elwira;Szostak, Michal research published 《 Cobalt-NHC Catalyzed C(sp²)-C(sp³) and C(sp²)-C(sp²) Kumada Cross-Coupling of Aryl Tosylates with Alkyl and Aryl Grignard Reagents》, the research content is summarized as follows. The first cobalt-catalyzed cross-coupling of aryl tosylates with alkyl and aryl Grignard reagents were reported. The catalytic system used CoF₃ and NHC (NHC=N-heterocyclic carbene) as ancillary ligands. The reaction proceeded via highly selective C-O bond functionalization, which leaded to the corresponding products in up to 98% yield. The employment of alkyl Grignard reagents allows to achieve a rare C(sp₂)-C(sp₃) cross-coupling of C-O electrophiles, circumvented isomerization and β-hydride elimination problems. The use of aryl Grignards resulted in formation of biaryls. The C-O cross-coupling sets the stage for a sequential cross-coupling by exploiting the orthogonal selectivity of the catalytic system.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pisano, Gianmarco team published research in ACS Sustainable Chemistry & Engineering in 2021 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Pisano, Gianmarco;Cazin, Catherine S. J. research published 《 General Mechanochemical Synthetic Protocol to Late Transition Metal-NHC (N-Heterocyclic Carbene) Complexes》, the research content is summarized as follows. A user-friendly and highly efficient mechanochem. strategy for the synthesis of a number of well-defined, catalytically relevant N-heterocyclic carbene-metal complexes under aerobic conditions is reported. This protocol proceeds in good to excellent yields and limits solvent usage to the purification step, which can be carried out, after judicious selection, using minimal amounts of environmentally benign solvents.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pisano, Gianmarco team published research in Green Chemistry in 2020 | 250285-32-6

HPLC of Formula: 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Pisano, Gianmarco;Cazin, Catherine S. J. research published 《 Mechanochemical synthesis of Cu(I)-N-heterocyclic carbene complexes》, the research content is summarized as follows. It is reported a general, operationally simple and scalable mechanochem. method for the synthesis of [Cu(Cl)(NHC)] complexes. This solid-state and solvent-less methodol. was shown to be applicable to a wide range of NHC ligand precursors, allowing access to complexes of the type [Cu(Cl)(NHC)] under aerobic conditions and with minimised environmental impact.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Prima, Darya O. team published research in Catalysis Science & Technology in 2021 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Prima, Darya O.;Madiyeva, Malena;Burykina, Julia V.;Minyaev, Mikhail E.;Boiko, Daniil A.;Ananikov, Valentine P. research published 《 Evidence for “cocktail”-type catalysis in Buchwald-Hartwig reaction. A mechanistic study》, the research content is summarized as follows. The mechanism of the C-N cross-coupling reaction, catalyzed by palladium complexes with N-heterocyclic carbene ligands (Pd/NHC), was evaluated in detail at the mol. and nanoscale levels. For the first time, the formation of a “cocktail”-type catalytic system was proven for the Buchwald-Hartwig reaction. The unique ability of the Pd/NHC system to generate several types of catalytic centers (Pd complexes, clusters and nanoparticles) and the involvement of complementary pathways (homogeneous and heterogeneous) were discovered to take place in a “one pot” manner directly in the reaction vessel. Access to various catalytic centers from a single and readily available Pd/NHC complex is the key to designing a universal catalytic system with adaptive tuning capability.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ng, Shan Shan team published research in Advanced Synthesis & Catalysis in 2022 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Ng, Shan Shan;Chen, Zicong;Yuen, On Ying;So, Chau Ming research published 《 Palladium-Catalyzed Chemoselective Borylation of (Poly)halogenated Aryl Triflates and Their Application in Consecutive Reactions》, the research content is summarized as follows. Chemoselective palladium-phosphine-catalyzed borylation of halogenated aryl triflates TfOC₆H_nY_4-nX (X = Cl, Br; Y = H, OMe, F, Me, PhCH₂, aryl, CN) gave boryl triflates TfOC₆H_nY_4-nBpin, which can be applied for Suzuki coupling with aryl chlorides in one-pot two-step procedure, giving functionalized biaryls. This study reports the palladium-catalyzed chemoselective borylation of (poly)halogenated aryl triflates with a reactivity order of C-Cl>C-OTf. A catalyst system comprising Pd(OAc)₂ and SelectPhos (L1) enables a reaction with high reactivity and chemoselectivity. The consecutively chemoselective borylation reaction followed by the chemoselective intermol. Suzuki-Miyaura reaction can be performed using a one-pot two-step approach to synthesize unsym. biaryl compounds containing the triflate moiety. The reaction can be scaled up to the gram scale without diminishing the yield and chemoselectivity.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Obst, Marc F. team published research in Organometallics in 2020 | 250285-32-6

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Obst, Marc F.;Gevorgyan, Ashot;Bayer, Annette;Hopmann, Kathrin H. research published 《 Mechanistic Insights into Copper-Catalyzed Carboxylations》, the research content is summarized as follows. The Cu-NHC-catalyzed carboxylation of organoboranes with CO₂ was studied using computational and exptl. methods. The DFT and DLPNO-CCSD(T) results indicate that nonbenzylic substrates are converted via an inner-sphere carboxylation of an organocopper intermediate, whereas benzylic substrates may simultaneously proceed along both inner- and outer-sphere CO₂ insertion pathways. The computations predict that two conceptually different carboxylation mechanisms are possible for benzylic organoboranes, one being Cu-catalyzed and one being mediated by the reaction additive CsF. The authors’ exptl. evaluation of the computed reactions confirms that carboxylation of nonbenzylic substrates requires Cu catalysis, whereas benzylic substrates can be carboxylated with and without Cu.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem