Tag: M.W=400-450

Menendez, Guillermo O. published the artcileA Versatile Near-Infrared Asymmetric Tricarbocyanine for Zinc Ion Sensing in Water, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Photochemistry and Photobiology (2013), 89(6), 1354-1361, database is CAplus and MEDLINE.

We have synthesized a near-IR emissive asym. tricarbocyanine conveniently functionalized to improve bioconjugation. The leading structure contains a versatile derivatization point at the meso position for facile radical-nucleophilic aromatic substitution. We have evaluated a DPEN (N,N-di(2-picolyl)ethylendiamine) derivative of this dye as a highly selective sensor for zinc (II) in aqueous medium, which performs in an appropriate sensitivity range for biol. studies. The probe was successfully conjugated to a protein-ligand model with high affinity and specificity (biotin-streptavidin technol.) rendering an excellent performance of sensing. In a general strategy to obtain sensitive probes combining fluorescent nanoparticles and mol. fluorophores, a preliminary design of a supramol. assembly derived from the conjugation of the mol. sensor to quantum dots (QDs) was also investigated. The advantages and problems of FRET-based sensors are also discussed.

Photochemistry and Photobiology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sioriki, Eleni published the artcileIn vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds, Product Details of C27H39ClN2, the publication is ChemMedChem (2018), 13(23), 2484-2487, database is CAplus and MEDLINE.

The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC·H][AuCl₂] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in anal. pure form. In addition, the biol. activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*·H][AuCl₂] (6) being the most potent inhibitor of PAF at micromolar concentration Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.

ChemMedChem published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C9H13NO2, Product Details of C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Youshan published the artcileBioorthogonal Ligation and Cleavage by Reactions of Chloroquinoxalines with ortho-Dithiophenols, Category: imidazoles-derivatives, the publication is Angewandte Chemie, International Edition (2020), 59(9), 3671-3677, database is CAplus and MEDLINE.

A bioorthogonal ligation and cleavage method via reactions of chloroquinoxalines (CQ) and ortho-dithiophenols (DT) is presented. Double nucleophilic substitutions of ortho-dithiophenols to chloroquinoxalines provide conjugates containing tetracyclic benzo[5,6][1,4]dithiino[2,3-b]quinoxaline with strong built-in fluorescence together with release of the other functional mols. Three cleavable linkers were designed and successfully used in release of the mols. containing biotin from the protein conjugates. The CQ-DT bioorthogonal reactions can be applied for the bioorthogonal ligations, bioorthogonal cleavages, and trans-tagging of proteins, and show advantages of readily accessible unnatural orthogonal groups, appealing reaction kinetics (k₂ â‰?1.3 m^-1 s^-1), excellent biocompatibility of orthogonal groups, and high stability of conjugates. This complements previous bioorthogonal reactions and is a new route for protein-fishing applications and in-gel fluorescence anal.

Angewandte Chemie, International Edition published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gu, Yang published the artcileLigand-Controlled Copper-Catalyzed Highly Regioselective Difluoromethylation of Allylic Chlorides/Bromides and Propargyl Bromides, Product Details of C27H39ClN2, the publication is Chinese Journal of Chemistry (2018), 36(1), 55-58, database is CAplus.

Highly regiodivergent copper-catalyzed allylic/propargylic difluoromethylation reactions by employing different ligands were described. When 5,6-dimethyl-1,10-phenanthroline was used as the ligand, exclusively α-difluoromethylated products I [R = 4-ClC₆H₄, 4-CF₃C₆H₄, 1-naphthyl, etc.] were obtained, while γ-selective difluoromethylated products II were generated when N-heterocyclic carbene-SIPr was used as the ligand. Likewise, α-difluoromethylated products III [Ar = 4-ClC₆H₄, 4-CF₃C₆H₄, 4-t-BuC₆H₄, etc.] and γ-difluoromethylated products IV were achieved in the presence of similar copper catalysts for the reactions of propargyl bromides. Moreover, a copper-catalyzed asym. allylic difluoromethylation reaction with moderate to good enantioselectivity by the use of chiral ligands was afforded α-difluoromethylated products II [R = 3-ClC₆H₄, 4-CO₂MeC₆H₄, 2,5-(Br)₂C₆H₃, etc.].

Chinese Journal of Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Product Details of C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jiang, Cheng published the artcileNi-Catalyzed 1,2-Acyl Migration Reactions Triggered by C-C Bond Activation of Ketones, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is ACS Catalysis (2020), 10(3), 1947-1953, database is CAplus.

A Ni-catalyzed 1,2-acyl migration triggered by C-C bond cleavage was developed. The process of 1,2-acyl migration followed by olefin isomerization provides a convenient access to α,β-unsaturated ketones, which are well-known building blocks in organic synthesis. Exptl. and computational studies show that the selective β-hydride elimination and Ni-hydride reinsertion play an essential role in this reaction.

ACS Catalysis published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Aslan, Kadir published the artcileControlled and Reversible Aggregation of Biotinylated Gold Nanoparticles with Streptavidin, SDS of cas: 359860-27-8, the publication is Journal of Physical Chemistry B (2004), 108(40), 15631-15639, database is CAplus.

Biotinylated gold nanoparticles were prepared by using a two-step surface modification procedure. First, a carboxyl-terminated alkanethiol was chemisorbed onto the surface of gold nanoparticles in the presence of a stabilizing agent. Subsequently, the carboxyl groups were reacted with (+)-biotinyl-3,6,9,-trioxaundecanediamine and 2-(2-aminoethoxy)ethanol. This procedure resulted in stable, ligand-modified gold nanoparticles. Upon interaction with streptavidin, the biotinylated gold nanoparticles aggregated by means of specific biomol. recognition. Their aggregation was studied by optical absorption spectroscopy. Controlled aggregation of biotinylated gold nanoparticles resulted in a shift in the surface plasmon resonance peak and broadening of the absorption spectrum of the nanoparticles. The spectral changes were used to assess the extent of aggregation. Aggregation was found to be dependent on the concentrations of streptavidin, biotinylated gold nanoparticles, and the surface mole fraction of biotin groups on the nanoparticles. Maximum aggregation was observed when 24 nM streptavidin and 0.80 nM biotinylated gold nanoparticles were used. Reversal of nanoparticle aggregation was accomplished by the addition of soluble biotin to the streptavidin-nanoparticle aggregates. Kinetic anal. of the absorbance data showed that streptavidin-induced aggregation of biotinylated gold nanoparticles could be interpreted in terms of a Reaction-Limited Colloidal Aggregation (RLCA) model. This indicates that optical absorption spectroscopy can provide a quant. measurement of the aggregation process.

Journal of Physical Chemistry B published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

He, Xi published the artcileEffect of mixed ionic liquids on chain entanglement and relaxation of poly (methyl methacrylate), Synthetic Route of 862731-66-6, the publication is Gaofenzi Xuebao (2021), 52(1), 84-93, database is CAplus.

A kind of dicationic ionic liquid (DIL) [C₈(MIM)₂][TFSI]₂ with double charged imidazole rings was successfully synthesized and mixed with a monocationic ionic liquids (MIL) [C₈ (MIM) ][TFSI]. Compared with MIL, the double imidazolium rings on the DIL cation greatly limits the vibration ability of the alkyl chain, which shows a much higher wavenumber in IR spectrum. The DIL/MIL mixtures show Arrhenius fluid behavior, and their viscosities follow the logarithmic mixing rule. With the increase of DIL content in the ILs mixtures, the viscosity and flow activation energy gradually increase, which is closely related to the mol. size and intermol. interaction of DIL. Then, the effect of mixed ILs on the entanglement and relaxation of poly (Me methacrylate) (PMMA) was extensively investigated by rheol. tests. The master curves obtained by time-temperature superposition principle show that DIL could significantly change the relaxation behavior and entanglement state of PMMA chains in mixed ILs. With increasing DIL content in the mixed ILs, both the terminal relaxation τ1 and entanglement relaxation τe of PMMA chains were retarded, and the entanglement network of the PMMA/ILs becomes more compact, showing higher plateau modulus and greater viscosity. More interaction sites could be formed between PMMA chains and DIL mols. due to its unique double imidazolium rings structure, which results in more cohesive entanglements among PMMA chains and thus restrict their relaxation. Moreover, there is a math. relationship between the rheol. parameters (such as τ₁ and τ_e) of PMMA/ILs and the viscosity of ILs mixtures, so the rheol. behavior of the system could be approx. predicted. On the other hand, thermal stability, glass transition and ion conductivity of PMMA/ILs were also discussed. The thermal decomposition temperature and glass transition temperature of PMMA/ILs increased with the DIL content, while the ionic conductivity decreased slightly.

Gaofenzi Xuebao published new progress about 862731-66-6. 862731-66-6 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid, name is 1-octyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide, and the molecular formula is C16H23F6N3O2, Synthetic Route of 862731-66-6.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Han, Bo published the artcileChromium- and Cobalt-Catalyzed, Regiocontrolled Hydrogenation of Polycyclic Aromatic Hydrocarbons: A Combined Experimental and Theoretical Study, Computed Properties of 258278-25-0, the publication is Journal of the American Chemical Society (2019), 141(22), 9018-9026, database is CAplus and MEDLINE.

Polycyclic aromatic hydrocarbons are difficult substrates for hydrogenation because of the thermodn. stability caused by aromaticity. We report here the first chromium- and cobalt-catalyzed, regiocontrolled hydrogenation of polycyclic aromatic hydrocarbons at ambient temperature These reactions were promoted by low-cost chromium or cobalt salts combined with diimino/carbene ligand and methylmagnesium bromide and are characterized by high regioselectivity and expanded substrate scope that includes tetracene, tetraphene, pentacene, and perylene, which have rarely been reduced. The approach provides a cost-effective catalytic protocol for hydrogenation, is scalable, and can be utilized in the synthesis of tetrabromo- and carboxyl-substituted motifs through functionalization of the hydrogenation product. The systematic theor. mechanistic modelings suggest that low-valent Cr and Co monohydride species, most likely from zerovalent transition metals, are capable of mediating these hydrogenations of fused PAHs.

Journal of the American Chemical Society published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Computed Properties of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yu, Hua-Zhong published the artcileReading Disc-Based Bioassays with Standard Computer Drives, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Accounts of Chemical Research (2013), 46(2), 258-268, database is CAplus and MEDLINE.

Traditional methods of disease diagnosis are both time-consuming and labor-intensive, and many tests require expensive instrumentation and trained professionals, which restricts their use to biomedical laboratories Because patients can wait several days (even weeks) for the results, the consequences of delayed treatment could be disastrous. Therefore, affordable and simple point-of-care (POC) biosensor devices could fill a diagnostic niche in the clinic or even at home, as personal glucose meters do for diabetics. These devices would allow patients to check their own health conditions and enable physicians to make prompt treatment decisions, which could improve the chances for rapid recovery and cure. Compact disks (CDs) provide inexpensive substrate materials for the preparation of microarray biochips, and conventional computer drives/disk players can be adapted as precise optical reading devices for signal processing. Researchers can employ the polycarbonate (PC) base of a CD as an alternative substrate to glass slides or silicon wafers for the preparation of microanal. devices. Using the characteristic optical phenomena occurring on the metal layer of a CD, researchers can develop biosensors based on advanced spectroscopic readout (interferometry or surface plasmon resonance). If researchers integrate microfluidic functions with CD mechanics, they can control fluid transfer through the spinning motion of the disk, leading to “lab-on-a-CD” devices. Over the last decade, the authors’ laboratory has focused on the construction of POC biosensor devices from off-the-shelf CDs or DVDs and standard computer drives. Besides the initial studies of the suitability of CDs for surface and materials chem. research (fabrication of self-assembled monolayers and oxide nanostructures), an ordinary optical drive, without modification of either the hardware or the software driver, can function as the signal transducing element for reading disk-based bioassays quant. In this Account, the authors first provide a brief introduction to CD-related materials chem. and microfluidics research. Then the authors describe the mild chem. developed in the authors’ laboratory for the preparation of computer-readable biomol. screening assays: photochem. activation of the polycarbonate (PC) disk surface and immobilization and delivery of probe and target biomols. The authors thoroughly discuss the anal. of the mol. recognition events: researchers can “read” these devices quant. with an unmodified optical drive of any personal computer. Finally, and critically, the authors illustrate the authors’ digitized mol. diagnosis approach with three trial systems: DNA hybridization, antibody-antigen binding, and ultrasensitive lead detection with a DNAzyme assay. These examples demonstrate the broad potential of this new anal./diagnostic tool for medical screening, on-site food/water safety testing, and remote environmental monitoring.

Accounts of Chemical Research published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C7H16ClNO2, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tran, Van T. published the artcileNi(COD)(DQ): An Air-Stable 18-Electron Nickel(0)-Olefin Precatalyst, Formula: C27H39ClN2, the publication is Angewandte Chemie, International Edition (2020), 59(19), 7409-7413, database is CAplus and MEDLINE.

We report that Ni(COD)(DQ) (COD = 1,5-cyclooctadiene, DQ = duroquinone), an air-stable 18-electron complex originally described by Schrauzer in 1962, is a competent precatalyst for a variety of nickel-catalyzed synthetic methods from the literature. Due to its apparent stability, use of Ni(COD)(DQ) as a precatalyst allows reactions to be conveniently performed without use of an inert-atm. glovebox, as demonstrated across several case studies.

Angewandte Chemie, International Edition published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C14H10O4, Formula: C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem