Tag: M.W=400-450

Wei, Kaijie published the artcileIron-Catalyzed 1,4-Phenyl Migration/Ring Expansion of α-Azido N-Phenyl Amides, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Organic Letters (2021), 23(21), 8650-8654, database is CAplus and MEDLINE.

A novel iron-catalyzed skeleton rearrangement of alkyl azides was reported. Upon treatment with FeCl₂ and N-heterocyclic carbene S_IPr·HCl in the presence of H₂O and Et₃N, 2-azido-N,N-diphenylamides underwent 1,4-Ph migration and ring expansion to give azepin-2-ones in good yield. The reaction proceeds via intramol. nitrene cycloaddition followed by C-N cleavage, water addition, and electrocyclic ring opening.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C18H10F3NO3S2, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yang, Peng-Yu published the artcileChemical Modification and Organelle-Specific Localization of Orlistat-Like Natural-Product-Based Probes, COA of Formula: C18H34N4O5S, the publication is Chemistry – An Asian Journal (2011), 6(10), 2762-2775, database is CAplus and MEDLINE.

Orlistat, also known as tetrahydrolipstatin (THL), is an FDA-approved anti-obesity drug with potential anti-cancer activity. Previously, we developed a chem. proteomic approach, based on the Orlistat-like probe (I) for large-scale identification of unknown cellular targets of Orlistat in human hepatocytes. In this article, we report the chem. synthesis and biol. evaluation of an expanded set of Orlistat-like compounds, with the intention to further dissect and manipulate potential cellular targets of Orlistat. In doing so, we carried out proteome-wide activity-based profiling and large-scale pull-down/LCMS anal. of these compounds in live HepG2 cells, and successfully identified many putative cellular targets for Orlistat and its structural analogs. By qual. assessing the spectra counts of potential protein hits against each of the seventeen Orlistat analogs, we obtained both common and unique targets of these probes. Our results revealed that subtle structural modifications of Orlistat led to noticeable changes in both the cellular potency and target profiles of the drug. In order to further improve the cellular activity of Orlistat, we successfully applied the well-established AGT/SNAP-tag technol. to our cell-permeable, benzylguanine (BG)-containing Orlistat variant (II). We showed that the drug could be delivered and effectively retained in different sub-cellular organelles of living cells. This strategy may provide a general and highly effective chem. tool for the potential sub-cellular targeting of small mol. drugs.

Chemistry – An Asian Journal published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C11H9NO3, COA of Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Bong Soo published the artcileSurface-Initiated, Atom Transfer Radical Polymerization of Oligo(ethylene glycol) Methyl Ether Methacrylate and Subsequent Click Chemistry for Bioconjugation, Quality Control of 359860-27-8, the publication is Biomacromolecules (2007), 8(2), 744-749, database is CAplus and MEDLINE.

Click chem. was applied to polymeric nanobrushes presenting azide groups at the terminal. Specifically, the non-biofouling oligoethylene glycol Me ether methacrylate film was functionalized to achieve maximized biospecific interactions between surface-attached ligands and target mols. with PEG as an inert background.

Biomacromolecules published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Zee-Won published the artcileSingle cell array of biotinylated cells using surface functionalization and microcontact printing, Category: imidazoles-derivatives, the publication is Chemistry Letters (2005), 34(5), 648-649, database is CAplus.

This paper describes a versatile method for generating single cell arrays on a glass substrate, which could be applicable to any arbitrary cell types, by a combination of surface functionalization, biotinylation of cells, and microcontact printing (μCP).

Chemistry Letters published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Park, Sangjin published the artcileDual Functional, Polymeric Self-Assembled Monolayers as a Facile Platform for Construction of Patterns of Biomolecules, Formula: C18H34N4O5S, the publication is Langmuir (2007), 23(22), 10902-10905, database is CAplus and MEDLINE.

The authors report a facile approach to the construction of patterns of biomols. based on polymeric self-assembled monolayers (pSAMs) that possess dual functions: “bio-reactive (post-functionalizable)” and “bio-inert (anti-biofouling)” properties. To prepare pSAMs on Si/SiO₂ wafers were new random copolymers synthesized by radical polymerization of poly(ethylene glycol) Me ether methacrylate (PEGMA), 3-(trimethoxysilyl)propyl methacrylate (TMSMA), and N-acryloxysuccinimide (NAS), and referred to as poly(TMSMA-r-PEGMA-r-NAS). Poly(TMSMA-r-PEGMA-r-NAS) was designed to play triple roles: “surface-reactive”, “bio-reactive”, and “bio-inert” ones. The pSAMs of poly(TMSMA-r-PEGMA-r-NAS) were formed on Si/SiO₂ wafers with 1 h incubation of the substrates in the polymer solution, which showed approx. a 1 nm-thick film as measured by ellipsometry. After the formation of the pSAMs, the feasibility of the pSAMs as a dual functional surface (bio-inert and bio-reactive properties) was examined The ability of the pSAMs to block nonspecific adsorption of proteins was evaluated against bovine serum albumin as a model protein. High-resolution N(1s) XPS anal. on the protein adsorption revealed that significant reduction up to âˆ?7% was observed compared to the unmodified Si/SiO₂ wafer. In addition, micropatterns of streptavidin with high signal-to-noise ratios were achieved using microcontact printing (μCP) of NH₂-bearing biotin onto the pSAMs of poly(TMSMA-r-PEGMA-r-NAS) on glass slides, which suggests that other biomols. could also be efficiently immobilized onto the pSAMs with high specificity while minimizing nonspecific adsorption. The surface d. of both bio-reactive and anti-biofouling functionality could be tailored by simply changing initial feed ratios of each monomer in the polymer synthesis:different molar ratios of the bio-reactive group (NAS: 33%, 20%, and 10%, resp.) were employed. When micropatterns of streptavidin were constructed, the pSAMs with 33% NAS moiety showed the highest immobilization of the protein. Taken together, the present dual functional, random copolymers may have warrant applications in the field of biosensors and biochips.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Sang Hyun published the artcileThe Hildebrand solubility parameters, cohesive energy densities and internal energies of 1-alkyl-3-methylimidazolium-based room temperature ionic liquids, Formula: C16H23F6N3O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2005), 3469-3471, database is CAplus and MEDLINE.

The Hildebrand solubility parameters, cohesive energy densities and internal energies of 1-alkyl-3-methylimidazolium-based room temperature ionic liquids were determined by the intrinsic viscosity method and their dependencies on the length of the alkyl group analyzed.

Chemical Communications (Cambridge, United Kingdom) published new progress about 862731-66-6. 862731-66-6 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid, name is 1-octyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide, and the molecular formula is C16H23F6N3O2, Formula: C16H23F6N3O2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hyun, Jinho published the artcileFabrication of “smart” protein nanostructures using molecular recognition and dip-pen nanolithography, Application of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is PMSE Preprints (2003), 261-262, database is CAplus.

Dip-pen nanolithog. in combination with the high-affinity streptavidin-biotin and streptavidin-iminobiotin protein ligand system provide a simple bottom-up approach to creating smart nanoscale biomol. structures in a step-wise fashion by patterning a self-assembled monolayer of a CO₂H-terminated alkanethiol on a gold substrate, followed by covalent immobilization of a high-affinity, small mol. ligand (biotin) on the nanopatterned self-assembled monolayer and mol. recognition of its protein binding partner, streptavidin from solution The resulting nanopattern provides a universal platform for mol. recognition-mediated protein immobilization. Both irreversible immobilization of a biotin-tagged protein and stimulus-triggered, reversible immobilization of N-hydroxysuccinimidoiminobiotin are presented.

PMSE Preprints published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Application of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhu, Shaoli published the artcileA localized surface plasmon resonance nanosensor based on rhombic Ag nanoparticle array, SDS of cas: 359860-27-8, the publication is Sensors and Actuators, B: Chemical (2008), 134(1), 193-198, database is CAplus.

A localized surface plasmon resonance (LSPR) nanosensor by using a rhombic Ag nanoparticle array is proposed and developed. The LSPR extinction spectra of the antigen or antibody with lower concentration are detected. The obtained results detected from 100 nM target mol. indicate a larger wavelength shift for the rhombic based nanosensor than the triangular based nanosensor. By exptl. detection, we demonstrated that the refractive index sensitivity is 266.2 nm per refractive index unit for Ag rhombic nanoparticle with in-plane width of �40 nm and out-of-plane height of 47 nm.

Sensors and Actuators, B: Chemical published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C6H10F3NO, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhou, Tongliang published the artcile[Pd(NHC)(acac)Cl]: Well-Defined, Air-Stable, and Readily Available Precatalysts for Suzuki and Buchwald-Hartwig Cross-coupling (Transamidation) of Amides and Esters by N-C/O-C Activation, Quality Control of 258278-25-0, the publication is Organic Letters (2019), 21(9), 3304-3309, database is CAplus and MEDLINE.

A general class of well-defined, air-stable, and readily available Pd(II)-NHC precatalysts (NHC = N-heterocyclic carbene) for Suzuki and Buchwald-Hartwig cross-coupling of amides (transamidation) and esters by selective N-C/O-C cleavage is reported. Since these precatalysts are highly active and the easiest to synthesize, the study clearly suggests that [Pd(NHC)(acac)Cl] should be routinely included during the development of new cross-coupling methods. An assay for in situ screening of NHC salts in this cross-coupling manifold is presented.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C18H23N3O4S, Quality Control of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yao, Wei-Wei published the artcileNi-catalyzed hydroaminoalkylation of alkynes with amines, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Nature Communications (2021), 12(1), 3800, database is CAplus and MEDLINE.

Here, a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes RCCR¹ (R = Me, n-Bu, Ph, 4-methoxyphenyl, etc.; R¹ = Me, i-Pr, TMS, 4-ethylphenyl, etc.) with N-sulfonyl amines R²CH₂NHR³ (R² = pentyl, cyclohexyl, Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R³ = Ms, Ts, [2,4,6-tris(propan-2-yl)phenyl]sulfonyl, etc.), providing a series of allylic amines R²CH(NHR³)C(=CHR¹)(R) in up to 94% yield was reported. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy₃) effectively promote the reaction.

Nature Communications published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C5H11NO2S, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem