Tag: M.W=400-450

Lahann, Joerg published the artcileMicroengineered surfaces for biomedical applications based on a polymer active ester, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2001), 42(2), 113-114, database is CAplus.

A generic method for generating patterns of proteins and/or cells based on reactive coating and spatially directed self-assembly was developed. [2.2]Paracyclophane-4-carboxylic acid pentafluorophenol (I) ester was synthesized via three step synthesis. A reactive coating process was done by chem. vapor deposition polymerization of I to produce a reactive film of poly[p-xylylene carboxylic acid pentafluorophenol ester-co-para-xylylene] on the substrate. Surface patterns of biotin-conjugated human antibody against α₅-integrin were designed by the following procedure: (1) reactive coating process, (2) surface patterning using microcontact printing, and (3) generating cell patterns by layer-by-layer self-assembly on the patterned substrates. The method was demonstrated in patterns of endothelial cells.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Blom, Elisabeth published the artcile⁶⁸Ga-Labeling of Biotin Analogues and their Characterization, COA of Formula: C18H34N4O5S, the publication is Bioconjugate Chemistry (2009), 20(6), 1146-1151, database is CAplus and MEDLINE.

Biotin- and ⁶⁸Ga-based tracers have been suggested as tools that could be used to monitor the survival of avidin-coated islets of Langerhans isolated from pancreas and used in transplantation, i.e., to liver. Three biotin analogs with various alkyl and poly(ethylene glycol) (PEG) chains coupled to DOTA were synthesized and labeled with ⁶⁸Ga. The ⁶⁸Ga labeling was studied at room temperature as well as elevated temperature using either conventional or microwave heating. Radioactivity incorporation reached 95% within 5 and 2 min using the, resp., conventional and microwave heating modes. The specific activity of the tracers was improved by preconcentration and purification of the generator eluate. The binding of the labeled and nonlabeled conjugates to avidin in solution was compared to the binding of native biotin. All compounds maintained good affinity for avidin, though introducing the linkers and chelator, especially the PEG-groups, somewhat decreased the binding affinity. The extent of binding of the labeled compounds to avidin was 54-91% after 5 min. Blocking experiments were performed confirming the specificity of the binding of biotin analogs to avidin. The stability of the three labeled compounds in human serum was studied. The stability of the biotin analog 8 (65% within 30 min) and avidin-biotin complex (80% within 120 min) might be sufficient for the monitoring of the islets of Langerhans. The tracers will be evaluated in in vitro experiments of avidin-coated islets of Langerhans and in transplantation models in vivo.

Bioconjugate Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, COA of Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chi, Young Shik published the artcileAsymmetrically functionalized, four-armed, poly(ethylene glycol) compounds for construction of chemically functionalizable non-biofouling surfaces, Synthetic Route of 359860-27-8, the publication is Chemistry – An Asian Journal (2009), 4(1), 135-142, database is CAplus and MEDLINE.

Asym. functionalized, four-armed, Tween20 derivatives that formed stable monomol. films on solid substrates were designed and synthesized. Thiol-modified Tween20 was used for forming self-assembled monolayers (SAMs) on gold, and maleimide-modified Tween20 was introduced onto SiO₂ surfaces with SAMs of (3-mercaptopropyl)trimethoxysilane through Michael addition These structurally modified Tween20 compounds gave the original characteristics of Tween20, non-biofouling (from ethylene glycol groups) and functionalizable (from OH groups) properties, to each substrate. The non-biofouling properties of the Tween20-coated gold and SiO₂ surfaces were investigated by surface plasmon resonance spectroscopy and ellipsometry, and these surfaces showed strong resistance against nonspecific adsorption of proteins. In addition, the biospecific binding of streptavidin was achieved after coupling of (+)-biotinyl-3,6,9-trioxaundecanediamine onto the non-biofouling surfaces through amide-bond formation.

Chemistry – An Asian Journal published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jeong, Seung Pyo published the artcileBinding behaviors of protein on spatially controlled poly[oligo(ethylene glycol) methacrylate] brushes grafted from mixed self-assembled monolayers on gold, Category: imidazoles-derivatives, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(40), 5291-5293, database is CAplus and MEDLINE.

Binding behaviors of streptavidin were studied with different lateral packing densities of biotin-functionalized, nonbiofouling pOEGMA brushes, synthesized by surface-initiated polymerization from mixed SAMs with different mole fractions of the polymerization initiator on Au surfaces.

Chemical Communications (Cambridge, United Kingdom) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jung, Chan-Hee published the artcileA study on the immobilization of biomolecules on poly(acrylic acid)-grafted MWCNTs prepared by radiation-induced graft polymerization, HPLC of Formula: 359860-27-8, the publication is Polymer (Korea) (2010), 34(2), 150-153, database is CAplus.

In this research. biomol.-immobilized multi-walled carbon nanotubes (MWCNTs) were prepared by using radiation-induced graft polymerization For the immobilization of biomols., the surface of MWNCTs was functionalized by radiation-induced graft polymerization of acrylic acid. Based on the results of TGA and Raman spectroscopy it was found that acrylic acid was effectively graft-polymerized on the MWCNTs. Biomols. such as DNA and proteins were immobilized onto the resultant poly(acrylic acid)-grafted MWCNTs. The results of the XPS and fluorescence microscopy confirmed that the biomols. were successfully immobilized on the poly(acrylic acid)-grafted MWCNTs.

Polymer (Korea) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, HPLC of Formula: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ganesan, Ramakrishnan published the artcilePhotoactive Diazoketo-Functionalized Self-Assembled Monolayer for Biomolecular Patterning, Category: imidazoles-derivatives, the publication is Langmuir (2009), 25(16), 8888-8893, database is CAplus and MEDLINE.

A diazoketo-functionalized alkoxysilane compound was synthesized, and its self-assembled monolayer (SAM) formation was studied on glass and silicon substrates. IR spectroscopy was employed to follow the photoreaction in this system, which proved that carboxylic groups were generated from diazoketo groups in the surface of the substrate. Photopatterning of biotin/streptavidin on the diazoketo-functionalized SAM shows the potential of this novel platform for biomol. patterning.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Garcia-Dominguez, Patricia published the artcileSynthesis of L-Au(I)-CF₂H Complexes and Their Application as Transmetalation Shuttles to the Difluoromethylation of Aryl Iodides, SDS of cas: 258278-25-0, the publication is Organometallics (2021), 40(17), 2923-2928, database is CAplus.

We describe herein two alternative protocols to efficiently prepare difluoromethylgold(I) complexes bearing ancillary ligands with different electronic and steric properties. LAu-OX (X = H and t-Bu) species, formed in the presence of base, have been identified as intermediate complexes involved in these transformations. The application of these compounds as “CF₂H transmetalation shuttles” from gold to palladium has been demonstrated in a Pd-catalyzed difluoromethylation reaction of aryl iodides, in which the Au-to-Pd transfer of “CF₂H” is feasible under stoichiometric conditions. These findings will pave the way for catalytic manifolds in gold chem.

Organometallics published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, SDS of cas: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jang, Kwang-Suk published the artcileBiolabeling and binding evaluation of amphiphilic nanocrystallopolymers, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Journal of Nanomaterials (2016), 7416532/1-7416532/7, database is CAplus.

Surfactant-like inorganic-organic hybrid mols. named as nanocrystallopolymers were designed by conjugation of the hydrophilic synthetic poly(amino acid), poly-α,β-(N-(2-hydroxyethyl)l-aspartamide), with hydrophobic inorganic nanoparticles. In aqueous media, amphiphilic nanocrystallopolymers form self-aggregates with unique morphologies. Here, a simple biolabeling method of nanocrystallopolymers was developed. Biotin was selected as a model biomol. The specific binding of biotin-labeled nanocrystallopolymers to the targeted surface was evaluated with a surface plasmon resonance sensor.

Journal of Nanomaterials published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ott, Ingo published the artcileMetal N-heterocyclic carbene complexes in medicinal chemistry, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Advances in Inorganic Chemistry (2020), 121-148, database is CAplus.

A review. Based on their strong s-donor properties N-heterocyclic carbene (NHC) ligands can form stable complexes with many transition metals. Numerous applications of metal NHC complexes have been developed in the field of chem. catalysis. The option to generate very stable complexes as well as the convenient access to a high number of structurally diverse NHC ligands have made them also attractive target compounds in inorganic medicinal chem. A fast increasing number of reports demonstrates that metal NHC complexes provide an excellent scaffold for metallodrug design and many examples have been studied pharmacol. in great detail. This chapter focuses on metal NHC complexes containing the selected metals ruthenium, rhodium, silver, iridium and gold.

Advances in Inorganic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yang, Jin published the artcilePreparation and catalytic properties of the triphenylarsine and triphenylstibine-stabilized tri-heteroleptic NHC-Pd-allyl complexes, SDS of cas: 258278-25-0, the publication is Journal of Organometallic Chemistry (2019), 35-40, database is CAplus.

A series of triphenylarsine and triphenylstibine-stabilized tri-heteroleptic NHC-Pd-allyl complexes were synthesized and characterized. The solid-state structures of the complexes shown mononuclear carbene palladium complexes, in which, each palladium center was coordinated by an N-heterocyclic carbene, the η³-coordinated allyl moiety and an As or Sb donor. Further investigation of the Pd complexes as catalysts in Sonogashira coupling reaction was carried out and the obtained complexes exhibited good reactivities for aryl bromides.

Journal of Organometallic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C15H20O6, SDS of cas: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem