Tag: M.W=400-450

Yang, Jin published the artcile(N-heterocyclic carbene)PdCl(N-heterocyclic carboxylate) complexes: Synthesis and catalytic activities towards arylation of benzoxazoles with aryl halides, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Applied Organometallic Chemistry (2018), 32(7), n/a, database is CAplus.

A series of N-heterocyclic carboxylate-stabilized N-heterocyclic carbene palladium complexes has been synthesized and fully characterized. The solid-state structures indicate that each of the palladium centers is coordinated by an N-heterocyclic carbene, a chloride and a bidentate N,O-donor N-heterocyclic carboxylate ligand. The catalytic performance of the complexes was screened and the results revealed that the complexes exhibit moderate to high catalytic activities for the direct C-H bond arylation of benzoxazoles with aryl bromides.

Applied Organometallic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C15H12O8, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Yan-Qing published the artcileQuinolinyl Imidazolidin-2-imine Nickel Catalyzed Efficient Copolymerization of Norbornene with para-Chlorostyrene, Category: imidazoles-derivatives, the publication is Chinese Journal of Polymer Science (2020), 38(9), 941-949, database is CAplus.

A series of novel quinolinyl imidazolidin-2-imine nickel complexes with different substituents on the imidazolidin-2-imine ligand were synthesized and characterized. The complexes in the presence of methylaluminoxane (MAO) as a cocatalyst catalyzed the copolymerization of norbornene (N) and styrene (S) or para-chlorostyrene (CS) with high activity (up to 1070 kg·mol^-1·h^-1). The installation of sterically bulky substituents on the imidazolidine-2-imine ligand was effective for the increase of the mol. weight and the comonomer content, affording high mol. weight copolymers with tunable CS content (0.57 mol%-11.7 mol%), in which the existence of Cl group can provide reaction site for the further functionalization of copolymers as well as the synthesis of graft or crosslinked polymers. The linear relationship between the comonomer content and the glass transition temperature of the copolymers and the monomer reactivity ratios in the copolymerization indicated the formation of the expected functionalized cyclic olefin copolymers (COC).

Chinese Journal of Polymer Science published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Xiao-qian published the artcileCationic polymerization of p-methylstyrene in ionic liquids media, Related Products of imidazoles-derivatives, the publication is Gaofenzi Xuebao (2019), 50(4), 375-383, database is CAplus.

In this study, cationic polymerization of p-methylstyrene (p-MeSt) was studied in ionic liquid (IL) reaction media. The effects of ILs on p-MeSt cationic polymerization were analyzed through d. functional theory (DFT) and exptl. method. The influences of various initiating systems on p-MeSt cationic polymerization were investigated, and the efficiencies of various ILs as reaction solvents were discussed. The structure of the polymerization product was characterized through ¹H-NMR and FTIR characterization analyses; number-average mol. weight (M_n) and mol. weight distribution were measured through gel permeation chromatog. (GPC); a temperature recorder tracked the relationship between polymerization system temperature variation and reaction time. The results showed that a CumOH (2-phenyl-2-propanol)/BF₃·OEt₂ initiating system is relatively effective in IL media over those frequently used in cationic polymerization reactions. The products polymerized in 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl) imide ([Bmim][NTf₂]) IL media have higher mol. weight and yield (up to 99%) and narrower mol. weight distribution (M_w/M_n is ∼ 2.0) than those in traditional mol. solvents (such as CH₂Cl₂). An anal. of the effects of ILs on polymerization indicated that ILs act as inert solvents in p-MeSt cationic polymerization and do not directly participate in the polymerization reaction. The ionic environment of IL cannot inhibit a chain transfer reaction completely, but can stabilize active species and disperse pos. charges. Thus, the polymerization reaction is milder in IL media than that in traditional mol. solvents. The results of IL recovery and reuse showed that these solvents can be used as reaction medium over a number of cycles without remarkable influence on the products. Finally, the corresponding elementary reaction mechanism of the cationic polymerization of p-MeSt initiated by the CumOH/BF₃·OEt₂ system in [Bmim][NTf₂] IL media was proposed in this study. As is known, ILs are recyclable and environmentally friendly green solvents. This study expands the reaction solvent of cationic polymerization and promotes the development of green chem.

Gaofenzi Xuebao published new progress about 862731-66-6. 862731-66-6 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid, name is 1-octyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide, and the molecular formula is C18H28B2O4, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lu, Bing published the artcileIron-catalyzed esterification of allylic sp³ C-H bonds with carboxylic acids: Facile access to allylic esters, HPLC of Formula: 258278-25-0, the publication is Tetrahedron Letters (2017), 58(25), 2490-2494, database is CAplus.

The first general and efficient iron-catalyzed esterification of allylic sp³ C-H bonds with carboxylic acids using ionic iron(III) complexes as a catalyst and DTBP (DTBP = di-tert-Bu peroxide) as an oxidant is achieved. A variety of allylic esters were synthesized in good to excellent yields using an ionic iron(III) complex as catalyst in a 5 mol% loading. This reaction is characterized by its high efficiency, broad substrate scope with excellent steric hindrance tolerance and good functional group compatibility.

Tetrahedron Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, HPLC of Formula: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hyun, Jinho published the artcileMicrostamping on an activated polymer surfaces: Patterning biotin and streptavidin onto common polymeric biomaterials, Synthetic Route of 359860-27-8, the publication is Langmuir (2001), 17(20), 6358-6367, database is CAplus.

Microstamping on an activated polymer surface (MAPS) is a methodol. that enables biomols. to be patterned on polymers with micrometer spatial resolution MAPS combines homogeneous surface derivatization of a polymer to introduce a reactive functional group followed by reactive microcontact printing (μCP) of a biol. ligand of interest, linked to an appropriate reactive group. We demonstrate here that polyethylene, polystyrene, poly(Me methacrylate), and poly(ethylene terephthalate) films can be successfully modified to introduce COOH groups on their surfaces, which can be subsequently patterned by reactive μCP of amine-terminated biotin after derivatization of the COOH groups with pentafluorophenol. XPS and time-of-flight secondary ion mass spectrometry (TOF-SIMS) confirmed the chem. of MAPS at each stage of the derivatization of the polymer surfaces and reactive μCP of biotin. Micropatterned biotin surfaces fabricated by MAPS were patterned with streptavidin by exploiting mol. recognition between biotin and streptavidin. The formation of streptavidin patterns was examined by fluorescence microscopy of Alexa488-labeled streptavidin and by TOF-SIMS imaging of ¹⁵N-labeled recombinant streptavidin, bound to biotin patterns. The contrast in the streptavidin micropatterns was optimized by examining the effect of blocking agents and streptavidin incubation time. Maximum contrast was obtained for binding of 0.1 μM streptavidin from a buffer containing 0.02% (volume/volume) Tween 20 detergent for an incubation time of 1 min.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pampalakis, G. published the artcile“Activography”: a novel, versatile and easily adaptable method for monitoring enzymatic activities in situ, Product Details of C18H34N4O5S, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(22), 3246-3248, database is CAplus and MEDLINE.

We developed “activog.” to map enzymic activities on tissue sections using activity-based probes. The assay was validated using a new protease-activity probe on skin biopsies to provide proof-of-concept. Activog. is more selective and tech. easier than the established in situ zymog., thus, adaptable in routine running clinico-chem. laboratories

Chemical Communications (Cambridge, United Kingdom) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Product Details of C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Vineberg, Jacob G. published the artcileDesign, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid-Camptothecin Combination Chemotherapy, Quality Control of 359860-27-8, the publication is Journal of Medicinal Chemistry (2014), 57(13), 5777-5791, database is CAplus and MEDLINE.

Novel tumor-targeting dual-warhead camptothecin conjugates with SB-T-1214, (two warheads), self-immolative disulfide linkers for drug release, biotin as the tumor-targeting moiety, and 1,3,5-triazine as the tripod splitter module, were designed and synthesized. The potency of these conjugates were evaluated against MX-1, MCF-7, ID8, L1210FR (BR+, biotin receptor overexpressed) and WI38 (BR-, normal) cell lines in the absence and presence of glutathione (GSH), which is an endogenous thiol that triggers drug release inside the cancer cells. With the GSH and resuspension protocol, one of them exhibited IC₅₀ values of 3.22-9.80 nM against all BR+ cancer cell lines, and 705 nM against WI38. Thus, there was a two orders of magnitude higher selectivity to cancer cells. Also, a clear cooperative effect was observed for the taxoid-camptothecin combination when two drugs were delivered to the cancer cells specifically in the form of a dual-warhead conjugate.

Journal of Medicinal Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C8H8O2, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ren, Wei published the artcilePalladium-NHC-Catalyzed Allylic Alkylation of Pronucleophiles with Alkynes, COA of Formula: C27H39ClN2, the publication is Organic Letters (2019), 21(19), 7956-7960, database is CAplus and MEDLINE.

The palladium-N-heterocyclic carbene (NHC)-catalyzed allylic alkylation of various pronucleophiles with alkynes has been accomplished under mild conditions. The protocol exhibits broad functional group compatibility and high atom economy. Moreover, the catalytic process avoids the use of external oxidants and acid as additives.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, COA of Formula: C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Huang, Shuai published the artcilePd-Catalyzed umpolung asymmetric allylic alkylation of hydrazones to vicinal tertiary and quaternary chiral carbon centers, Quality Control of 258278-25-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(21), 3513-3516, database is CAplus and MEDLINE.

Diastereo- and enantioselective construction of vicinal tertiary and quaternary carbon centers is a great challenge in synthetic chem. Herein, a facile and efficient protocol to construct unsaturated azo compounds I [R¹ = Ph, 4-FC₆H₄, 2-naphthyl, 2-thienyl, etc., R² = Me; R¹ = Ph, R² = Et; R¹R² = (CH₂)₅; R³ = Ph, 4-MeOC₆H₄, 1,3-benzodioxol-5-yl, 2-furyl, etc.] with vicinal tertiary and quaternary chiral carbon centers in high yields with high regio-, diastereo- and enantioselectivities via Pd-catalyzed umpolung asym. allylic alkylation of hydrazones II with monosubstituted allylic pivalates R³CH:CHCH₂OC(O)Bu-t by using Kundig-type chiral N-heterocyclic carbene as the ligand is reported. The control experiments revealed that the reaction proceeds via the inner-sphere mechanism.

Chemical Communications (Cambridge, United Kingdom) published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Quality Control of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lin, Lei published the artcileHigh-throughput method for in process monitoring of 3-O-sulfotransferase catalyzed sulfonation in bioengineered heparin synthesis, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Analytical Biochemistry (2019), 113419, database is CAplus and MEDLINE.

Bioengineered heparin (BEH) offers a potential alternative for the preparation of a safer pharmacol. heparin. Construction of in-process control assays for tracking each enzymic step during bioengineered heparin synthesis remains a challenge. Here, we report a high-throughput sensing platform based on ELISA (ELISA) and enzymic signal amplification that allows the rapid and accurate monitoring of the 3-OST sulfonation in BEH synthesis process. The anticoagulant activity of target BEH was measured to reflect the degree of sulfonation by testing its competitive antithrombin (AT) binding ability. BEH samples with different sulfonation degrees show different AT protein binding capacity and thus changes the UV response to a different extent. This BEH-induced signal can be conveniently and sensitively monitored by the plate sensing system, which benefits from its high sensitivity brought in by the enzymic signal amplification. Furthermore, modification convenience and mech. robustness also ensure the stability of the test platform. This proposed strategy exhibits excellent anal. performance in both BEH activity anal. and 3-OST sulfonation evaluation. The simple and sensitive plate system shows great potential in developing on-chip, high-throughput methods for fundamental biochem. process research, drug discovery, and clinic diagnostics.

Analytical Biochemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem