Tag: M.W=50-100

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Formula: C4H4N2O.

Naidu, Bandameeda Ramesh;Lakshmidevi, Jangam;Naik, Bukke Siva Sankar;Venkateswarlu, Katta research published 《 Water extract of pomegranate ash as waste-originated biorenewable catalyst for the novel synthesis of chiral tert-butanesulfinyl aldimines in water》, the research content is summarized as follows. Renewable materials-catalyzed reactions in aqueous media are urgently needed and highly fascinating tasks in the current state of organic synthesis. Here, we report a novel and sustainable protocol for the biorenewable, waste-originated water extract of pomegranate ash (WEPA) catalyzed condensation reaction of tert-butanesulfinamides and aldehydes in water to produce chiral tert-butanesulfinyl aldimines (tBSAIs) in high yields. The products are separated by filtration and purified by recrystallization, avoiding extraction and column chromatog. separation steps. The reaction was performed with high yields in several consecutive recycles of the catalyst and medium; and further, this method is highly effective for the multi-gram scale synthesis of tBSAIs. The application of biorenewable catalyst, added metal/catalyst-free conditions, absence of volatile organic solvents and additives, vast substrate feasibility, economical profiles, easy operation, reusability of the catalyst, large scale viability, non-chromatog. purification of products, and tremendous future perspective are the sparkling insights of this development.

Formula: C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Safety of Imidazole-4-carbaldehyde.

Nguyen, Hai Truong;Le, Tan Van;Tran, Phuong Hoang research published 《 AC-SO₃H/[CholineCl][Urea]₂ as a green catalytic system for the synthesis of pyrano[2,3-c]pyrazole scaffolds》, the research content is summarized as follows. A sulfonated amorphous carbon (AC-SO₃H) was prepared from rice husk with sulfuric acid and fully characterized using FT-IR spectroscopy, X-ray diffraction (XRD), SEM (SEM), energy-dispersive X-ray spectroscopy (EDS). Deep eutectic solvent between choline chloride and urea was obtained from cheap and available material. The as-synthesized AC-SO₃H was applied to prepare pyrano[2,3-c]pyrazoles I [Ar = Ph, 2-furyl, 4-MeC₆H₄, etc.] through a four-component reaction of aromatic aldehydes, Et acetoacetate, hydrazines and malononitrile with moderate to good yields in deep eutectic solvent at room temperature The catalytic system was synthesized easily through a low-cost, non-toxic, eco-friendly and simple procedure with potential application in large-scale process.

Safety of Imidazole-4-carbaldehyde, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Electric Literature of 3034-50-2.

Nguyen, Huong T. D.;Nguyen, The T.;Nguyen, Phuong T. K.;Tran, Phuong Hoang research published 《 A highly active copper-based metal-organic framework catalyst for a Friedel-Crafts alkylation in the synthesis of bis(indolyl)methanes under ultrasound irradiation》, the research content is summarized as follows. A robust copper-based metal-organic framework (MOF) catalyst, termed as MOF-891, was successfully applied to the synthesis of the family of bioactive compounds, bis(indolyl)methanes I (R¹ = H, 5-NO₂, 5-Me, 5-Br; R² = 3-bromophenyl, 4-methoxyphenyl, 1H-imidazol-4-yl, etc.), through a Friedel-Crafts alkylation under ultrasound irradiation The remarkable catalytic activity of MOF-891 was proven by the successful synthesis of bis(indolyl)methanes I in high yield (up to 96%) and purity. In MOF-891, there exist two types of copper clusters, one discrete and one infinite rod, both are formed through water mols. triggering hydrogen bonds demonstrated the participation as catalytic active site for the Friedel-Crafts alkylation reaction. The well-defined construction of hydrogen bonds in MOF-891 along with Lewis copper sites attributed a stable catalysis activity and exhibited the heterogeneous nature with no significant loss of catalytic performance after six cycles.

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Electric Literature of 3034-50-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Reference of 1739-84-0.

Nie, Yiwen;Chen, Junjie;Wu, Zhihui;Zhou, Jinyue;Li, Zhenghan;Gao, Shanjun;Shen, Chunhui research published 《 Crosslinked anion exchange membranes based on styrene/acrylonitrile/vinylimidazole copolymer and PPO》, the research content is summarized as follows. Aliphatic polymers, such as polypropylene, styrene ethylene butylene styrene and norbornene, which show great alk. stability and flexibility, have become the main research trend of the skeleton of anion exchange membranes. Here, we prepared a copolymer with all carbon atoms on the main chain. Firstly, a new vinylimidazole cationic monomer was prepared, and then copolymerized with styrene and acrylonitrile to obtain a copolymer (PASIm). Furthermore, (2,6-dimethyl-1,4-phenylene oxide) (PPO) was introduced to crosslink with PSAIm to prepare AEMs with different crosslinking degrees (CEM-X, X = 6,12,18,24,30). 1H NMR and FT-IR showed that PASIm was successfully synthesized and crosslinked with PPO. The prepared membranes had high hydroxide ionic conductivity and excellent alk. stability. AFM showed that the CEM-18 had obvious microphase separation structure, which was beneficial to the construction of ion channels in the membrane. Thus, the CEM-18 showed the highest ionic conductivity, up to 59.21 mS cm-1 at 80°C. CEM-24 with higher crosslinking degree showed the highest alk. stability. After immersing in 1 M KOH solution at 80°C for 240 h, 86.52% of the initial ionic conductivity was retained. These results indicate that the prepared anion exchange membranes have broad application prospects.

Reference of 1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. COA of Formula: C5H8N2.

Niizeki, Takeru;Hoshina, Taka-Aki;Takahashi, Tomoki research published 《 Characterizations of thermo-responsive alkyl imidazolium perchlorates for forward osmosis membrane process》, the research content is summarized as follows. The forward osmosis (FO) process uses a spontaneous water permeation phenomenon driven by an osmotic pressure difference between a feed solution (FS) and a draw solution (DS) through a semipermeable membrane. Hence, it is assumed that seawater desalination and feed solution concentration using FO processes can be conducted at low energy and cost. It is crucial to develop an optimal DS for the FO process before it can be put into practical use. The DS must have the following characteristics: (1) Develops higher osmotic pressure than FS, (2) Easy to regenerate and recover, (3) Low leakage, and (4) Low viscosity. Particularly, we propose low-grade waste heat to reduce energy consumption during DS regeneration and chose a temperature phase transition type DS that separates into water and solute components based on thermal response. In this study, we synthesized six alkyl imidazolium type ionic liquids (ILs) having perchlorate anion ([ClO₄]), phase transition characteristics, and osmotic pressure, and the consequent FO performance was examined The synthesized ILs, 1-ethyl-3-propylimidazolium perchlorate [Im (2.0.3)] [ClO4] and 1,2-dimethyl-3-propylimidazolium perchlorate [Im(1.1.3)][ClO₄], showed an upper critical solution temperature type phase transition in the temperature range of 25 ° to 50 °. The FO test confirms that pure water can be derived from saltwater using the osmotic pressure of DS. In comparison to other synthesized ILs, [Im (1.1.3)] [ClO₄] showed higher performance in phase diagrams and osmotic pressure.

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., COA of Formula: C5H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Related Products of 1739-84-0.

Niu, Zhen;Wu, Ruiyao;Yang, Yinxin;Huang, Lingyun;Fan, Weifeng;Dai, Quanquan;Cui, Long;He, Jianyun;Bai, Chenxi research published 《 Recyclable, robust and shape memory vitrified polyisoprene composite prepared through a green methodology》, the research content is summarized as follows. Due to the weak mech. performance of raw rubber, it cannot meet the actual use requirements, thus crosslinking and reinforcement have been the eternal theme of rubber materials. However, this permanent crosslinking structure brings the dilemma that the rubber materials cannot be recycled after the life cycle, which causes energy waste and serious environmental pollution. Herein, we present a facile and green methodol. to prepare covalently cross-linked yet recyclable and robust polyisoprene-based vitrimer. The carboxylated carbon nanodots (CNDs) were selected as both crosslinkers and reinforcing components to react with epoxidized polyisoprene (EPI) for the construction of dynamic crosslinked networks with exchangeable β-hydroxyl ester bonds for the first time. The dynamic covalent linkages endowed the EPI-based vitrimers with reprocessability and excellent shape memory performance. In addition, the dynamic exchangeable interface enables CNDs well-dispersed in the EPI matrix, which exhibited high reinforcement efficiency on the mech. properties of EPI composite.

Related Products of 1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Safety of 1H-Imidazole-2-carbaldehyde.

Novendra, Novendra;Marrett, Joseph M.;Katsenis, Athanassios D.;Titi, Hatem M.;Arhangelskis, Mihails;Friscic, Tomislav;Navrotsky, Alexandra research published 《 Linker substituents control thermodynamic stability in metal organic frameworks》, the research content is summarized as follows. We report the first systematic exptl. and theor. study of the relationship between the linker functionalization and the thermodn. stability of metal-organic frameworks (MOFs) using a model set of eight isostructural zeolitic imidazolate frameworks (ZIFs) based on 2-substituted imidazolate linkers. The frameworks exhibit a significant (30 kJ·mol^-1) variation in the enthalpy of formation depending on the choice of substituent, which is accompanied by only a small change in molar volume. These energetics were readily reproduced by d. functional theory (DFT) calculations We show that these variations in the enthalpy of MOF formation are in linear correlation to the readily accessible properties of the linker substituent, such as the Hammett σ-constant or electrostatic surface potential. These results provide the first quantifiable relationship between the MOF thermodn. and the linker structure, suggesting a route to design and tune MOF stability.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Safety of 1H-Imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Related Products of 1739-84-0.

Oba, Yasuhiro;Takano, Yoshinori;Furukawa, Yoshihiro;Koga, Toshiki;Glavin, Daniel P.;Dworkin, Jason P.;Naraoka, Hiroshi research published 《 Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites》, the research content is summarized as follows. The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chem. models and laboratory experiments have predicted that these compounds can also be produced from chem. precursors found in meteorites. Here we report the detection of nucleobases in three carbonaceous meteorites using state-of-the-art anal. techniques optimized for small-scale quantification of nucleobases down to the range of parts per trillion (ppt). In addition to previously detected purine nucleobases in meteorites such as guanine and adenine, we identify various pyrimidine nucleobases such as cytosine, uracil, and thymine, and their structural isomers such as isocytosine, imidazole-4-carboxylic acid, and 6-methyluracil, resp. Given the similarity in the mol. distribution of pyrimidines in meteorites and those in photon-processed interstellar ice analogs, some of these derivatives could have been generated by photochem. reactions prevailing in the interstellar medium and later incorporated into asteroids during solar system formation. This study demonstrates that a diversity of meteoritic nucleobases could serve as building blocks of DNA and RNA on the early Earth.

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., Related Products of 1739-84-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Product Details of C4H4N2O.

Oggianu, Mariangela;Mameli, Valentina;Monni, Noemi;Sahadevan, Suchithra Ashoka;Angotzi, Marco Sanna;Cannas, Carla;Mercuri, Maria Laura research published 《 Nanoscaled metal-organic frameworks: challenges towards biomedical applications》, the research content is summarized as follows. Achieving metal-organic frameworks (MOFs) in the form of nanoparticles (NanoMOFs) represents a recent challenge due to the possibility to combine the intrinsic porosity of these materials with the nanometric dimension, a fundamental requirement for strategic biomedical applications. In this outlook we envision the current/future opportunities of the NanoMOFs in the field of biomedicine, with particular emphasis on (i) biocompatible MOFs composition; (ii) MOFs miniaturization and (iii) nanoMOFs applications.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Product Details of C4H4N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Quality Control of 3034-50-2.

Onyedibe, Kenneth I.;Dayal, Neetu;Sintim, Herman O. research published 《 SF₅– and SCF₃-substituted tetrahydroquinoline compounds as potent bactericidal agents against multidrug-resistant persister Gram-positive bacteria》, the research content is summarized as follows. Bacteria persister cells are immune to most antibiotics and hence compounds that are active against persister bacteria are needed. We screened a chem. library of SF₅– and SCF₃-substituted tetrahydroquinoline compounds, synthesized via the Povarov reaction, for antibacterial activity and identified active compounds that displayed good activities against many Gram-pos. bacteria, including persisters. The most potent of these compounds, HSD1835, inhibited the growth of drug-resistant Gram-pos. bacterial pathogens (including clin. strains) at concentrations ranging from 1 μg mL^-1 to 4 μg mL^-1. Several of the SCF₃– and SF₅-containing compounds were active against methicillin-resistant Staphylococcus aureus (MRSA) and against the two most fatal strains of vancomycin-resistant Enterococcus (VRE), VRE faecalis and VRE faecium. The compounds showed bactericidal activity against stationary phase persister MRSA in time-kill assays. Mechanistic studies showed that HSD1835 acts by disrupting bacterial membranes. SEM (SEM) was used to confirm bacterial membrane disruption. Interestingly, in a 30 day serial exposure experiment, MRSA remained susceptible to low-dose HSD1835 while resistance to ciprofloxacin and mupirocin emerged by day 10. Analogs of HSD1835, which did not bear the SF₅ or SCF₃ moieties, were inactive against bacteria. Recent reports (G.A.Naclerio, N.S.Abutaleb, K.I.Onyedibe, M.N.Seleem and H.O.Sintim, RSC Med.Chem. 2020, 11, 102-110 and G.A.Naclerio, N.S.Abutaleb, D.Li, M.N.Seleem and H.O.Sintim, J.Med.Chem. 2020, 63(20), 11934-11944) also demonstrated that adding the SF₅ or SCF₃ groups to a different scaffold (oxadiazoles) enhanced the antibacterial properties of the compounds, so it appears that these groups are privileged moieties that enhance the antimicrobial activities of compounds Naclerio, N. S. Abutaleb, D. Li, M. N. Seleem and H. O. Sintim, J. Med. Chem. 2020, 63(20), (11934-11944) also demonstrated that adding the SF5 or SCF3 groups to a different scaffold (oxadiazoles) enhanced the antibacterial properties of the compounds, so it appears that these groups are privileged moieties that enhance the antimicrobial activities of compounds

Quality Control of 3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem