Tag: M.W=50-100

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Reference of 1739-84-0.

Kumar, Sunil;Singh, Sohan;Gadwal, Jitendra;Makar, Parvesh;Joshi, Hemant research published 《 Regioselective C-H arylation of imidazoles employing macrocyclic palladium(II) complex of organoselenium ligand》, the research content is summarized as follows. In this report, a new air stable bidentate selenium ligand was synthesized by the reaction of 1,8-bis(2-(chloromethyl)phenoxy)octane with sodium salt of phenylselenol. The reaction of this ligand with Pd(CH₃CN)₂Cl₂ in acetonitrile under reflux conditions resulted in 19-membered ring macrocyclic palladium(II) complex. The structure of ligand precursors, ligand, and macrocyclic palladium(II) complex were authenticated by using ¹H, ¹³C{1H} NMR spectroscopy and elemental anal. The obtained air and moisture stable, thermally robust macrocyclic palladium(II) complex was employed as catalyst for regioselective arylation of 1-methylimidazole and 1,2-dimethylimidazole with a variety of aryl bromides. The mild reaction conditions, exclusive C-5 regioselectivity, excellent yields (∼73-95%), low catalyst loading (1.5 mol%) and functional group tolerance are the advantages of this protocol. Homogeneous nature of catalysis process was confirmed with the help of mercury and triphenylphosphine poisoning tests. The catalyst can be recycled and reused with significant loss (22%) in efficiency.

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., Reference of 1739-84-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Application In Synthesis of 3034-50-2.

Kumar, Yeeshu;Mahendar, Chinthakuntla;Kalam, Abul;Dubey, Mrigendra research published 《 Li⁺-Zn²⁺ tailored nanostructured metallohydrogel based mixed ionic-electronic conductors》, the research content is summarized as follows. A conductive metallohydrogel (MHG) has been obtained via in situ LiOH deprotonation of mandelic acid derived ligand H2IML followed by coordination of Zn2+ with an objective to fabricate a mixed ionic-electronic conductor (MIEC) without using any external dopant to the gel matrix. The MHG has been well characterized by UV-vis, ESI-mass, FT-IR, NMR, PXRD, FE-SEM, TEM and rheol. techniques to gain insight into the mechanism of gel formation. The conductive nature of the MHG (3.06 x 10-2 S cm-1) and its utilization as a mixed ionic-electronic conductor have been well established by EIS measurements.

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Application In Synthesis of 3034-50-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Product Details of C5H8N2.

Kundu, Abhinanda;Chandra, Shubhadeep;Mandal, Debdeep;Neuman, Nicolas I.;Mahata, Alok;Anga, Srinivas;Rawat, Hemant;Pal, Sudip;Schulzke, Carola;Sarkar, Biprajit;Chandrasekhar, Vadapalli;Jana, Anukul research published 《 Twisted Push-Pull Alkenes Bearing Geminal Cyclicdiamino and Difluoroaryl Substituents》, the research content is summarized as follows. The systematic combination of N-heterocyclic olefins (NHOs) with fluoroarenes resulted in twisted push-pull alkenes. These alkenes carry electron-donating cyclicdiamino substituents and two electron-withdrawing fluoroaryl substituents in the geminal positions. The synthetic method can be extended to a variety of substituted push-pull alkenes by varying the NHO as well as the fluoroarenes. Solid-state mol. structures of these mols. reveal a notable elongation of the central C-C bond and a twisted geometry in the alkene motif. Absorption properties were investigated with UV-vis spectroscopy. The redox properties of the twisted push-pull alkenes were probed with electrochem. as well as UV-vis/NIR and EPR spectroelectrochem., while the electronic structures were computationally evaluated and validated.

Product Details of C5H8N2, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Recommanded Product: 1H-Imidazole-2-carbaldehyde.

Lakshmanan, Kaviarasan;Hemanth, Kantabathina;Krishnamurthy, Praveen T.;Rajagopal, Kalirajan;Byran, Gowramma research published 《 Design, Synthesis, and In-Vitro Biological Evaluation of PARP-1 Inhibitors Based on a 4-(Benzylideneamino)-N-(Quinolin-8-yl)Benzamide Scaffold》, the research content is summarized as follows. Novel poly(ADP-ribose)polymerase (PARP)-1 inhibitors containing, the 4-(benzylideneamino)-N-(quinolin-8-yl)benzamide moiety, were designed and synthesized. The docking study revealed that the designed compounds possess significant to moderate interaction with the targeted enzyme PARP1. Among them compound I (-52.04 K/cal) and II (-50.234 K/cal) showed similar Glidescore compared to Olaprib (-57.76 K/cal). Some of the synthesized compounds displayed good PARP-1 inhibitory activity, and among them, I and II were the most potent one. Enzyme inhibitory assay indicated that the compounds I, II, III and IV exhibited an enzyme inhibitory activity against PARP-1 enzyme similar to that of olaparib. All the synthesized compounds were screened for their in vitro anticancer activity against MCF-7 and MDA-MB-232 cell lines. Among them, compound I (60.63 μg/mL and 56.38 μg/mL) and II (368.03 μg/mL and 54.42 μg/mL) were the most potent ones. In addition, ADMET prediction results indicated that these compounds might be less toxic and display more interesting pharmacokinetic properties.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Recommanded Product: 1H-Imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. COA of Formula: C4H4N2O.

Lee, Sumin;Chung, Clive Yik-Sham;Liu, Pei;Craciun, Laura;Nishikawa, Yuki;Bruemmer, Kevin J.;Hamachi, Itaru;Saijo, Kaoru;Miller, Evan W.;Chang, Christopher J. research published 《 Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper》, the research content is summarized as follows. Copper is a required nutrient for life and particularly important to the brain and central nervous system. Indeed, copper redox activity is essential to maintaining normal physiol. responses spanning neural signaling to metabolism, but at the same time copper misregulation is associated with inflammation and neurodegeneration. As such, chem. probes that can track dynamic changes in copper with spatial resolution, especially in loosely bound, labile forms, are valuable tools to identify and characterize its contributions to healthy and disease states. The authors present an activity-based sensing (ABS) strategy for copper detection in live cells that preserves spatial information by a copper-dependent bioconjugation reaction. Specifically, the authors designed copper-directed acyl imidazole dyes that operate through copper-mediated activation of acyl imidazole electrophiles for subsequent labeling of proximal proteins at sites of elevated labile copper to provide a permanent stain that resists washing and fixation. To showcase the utility of this new ABS platform, the authors sought to characterize labile copper pools in the three main cell types in the brain: neurons, astrocytes, and microglia. Exposure of each of these cell types to physiol. relevant stimuli shows distinct changes in labile copper pools. Neurons display translocation of labile copper from somatic cell bodies to peripheral processes upon activation, whereas astrocytes and microglia exhibit global decreases and increases in intracellular labile copper pools, resp., after exposure to inflammatory stimuli. This work provides foundational information on cell type-dependent homeostasis of copper, an essential metal in the brain, as well as a starting point for the design of new activity-based probes for metals and other dynamic signaling and stress analytes in biol.

COA of Formula: C4H4N2O, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Safety of 1,2-Dimethyl-1H-imidazole.

Lee, Yun-Yang;Penley, Drace;Klemm, Aidan;Dean, William;Gurkan, Burcu research published 《 Deep Eutectic Solvent Formed by Imidazolium Cyanopyrrolide and Ethylene Glycol for Reactive CO₂ Separations》, the research content is summarized as follows. Solvents made from a reactive ionic liquid, with an imidazolium cation and pyrrolide anion, and ethylene glycol at a wide compositional range were studied for separations of CO₂ at low partial pressures (≪0.1 bar up to 1 bar). Thermal anal. and measurements of viscosity and d. show compacting of the liquid upon mixing with enhanced stability achieved by hydrogen bonding. A detailed mechanistic study was performed by IR, quant. NMR, and ab initio calculations that show significant CO₂ absorption capacity below 5000 ppm of CO₂ in N₂. Three reversible routes are found that yield carbonate (major product), carboxylate (moderate), and carbamate (minor) species. With CO₂ at 100% RH, bicarbonate along with carbonate species form. The CO₂-ethlyene glycol reaction complex, the carbonate anion, is stabilized by the hydrogen bonding and Coulombic interactions, thus preventing evaporation of the solvent during regeneration. This study demonstrates a promising approach to designer green solvents for CO₂ separations in open systems such as direct air capture. Functional solvents with very low volatility are demonstrated for reactive CO₂ separations suitable for direct air capture.

Safety of 1,2-Dimethyl-1H-imidazole, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Recommanded Product: 1H-Imidazole-2-carbaldehyde.

Lei, Yuting;Zhang, Guihua;Zhang, Qinglan;Yu, Ling;Li, Hua;Yu, Haili;He, Yi research published 《 Visualization of gaseous iodine adsorption on single zeolitic imidazolate framework-90 particles》, the research content is summarized as follows. Zeolitic imidazolate frameworks (ZIFs) are very useful as high-capacity iodine (I2) adsorbents. The adsorption performance is usually probed by measuring a statistical average property over an entire sample consisting of a large number of ZIF particles, leaving the interparticle heterogeneity information among individuals. Here we report a dark-field microscopy (DFM) method to visualize gaseous I2 adsorption on single ZIF-90 particles in situ and in real time. The adsorption of I2 is found to alter the scattering spectrum of ZIF-90 particles, inducing a distinct color change from bluewhite to yellow. According to correlating the adsorption amount of gaseous I2 with the change of B value from DFM images, we quant. image the adsorption process and estimate the related kinetic parameters at the single particle level. Single particle measurements clarify the large particle-to-particle heterogeneity in adsorption reactivity and significant adsorption activity improvement of ZIF-90 after introduction of linker defects, which provides a microscopic understanding of the structure-activity relationship. We further demonstrate the capacity of this strategy for studying gaseous I2 adsorption on single ZIF-91 particle as a derivative of ZIF-90 to illustrate the generality.

Recommanded Product: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Quality Control of 10111-08-7.

Lei, Zhiwen;Shen, Jinlai;Wang, Jun;Qiu, Qi;Zhang, Guangzhao;Chi, Shang-Sen;Xu, Hongli;Li, Shuai;Zhang, Weide;Zhao, Yusheng;Deng, Yonghong;Wang, Chaoyang research published 《 Composite polymer electrolytes with uniform distribution of ionic liquid-grafted ZIF-90 nanofillers for high-performance solid-state Li batteries》, the research content is summarized as follows. The stable structure, high porosity and surface functionality endow metal organic frameworks (MOFs) nanoparticles as excellent nanofillers for high-performance poly (ethyleneoxide)-based solid polymer electrolytes (PEO SPEs). However, the agglomeration of MOFs severely limits their potential applications. Herein, a novel zeolitic imidazolate framework-90 nanofiller grafted with imidazole ionic liquid containing siloxane groups (ZIF-90-g-IL) is prepared by dehydration condensation reaction, which enables the uniform distribution of the nanofiller in PEO SPEs. The resulting composite PEO SPE with ZIF-90-g-IL nanofillers delivers higher ionic conductivity of 1.17 x 10-4 S/cm at 30°C and lithium ion transference number of 0.44, wider electrochem. stability window of 4.8 V, and stronger ability to inhibit lithium dendrite growth than the PEO SPE with unmodified ZIF-90. The strong interaction of ZIF-90-g-IL with PEO is caused by the chelation of quaternary ammonium cations of ionic liquid groups on the ZIF-90-g-IL surface with oxygen containing a lone pair of electrons of PEO, resulting in a uniform distribution of the nanofillers in PEO. The LFP||Li half cells with the PEO/ZIF-90-g-IL SPE exhibit good cycling performance with 71% capacity retention (101 mAh g-1) after 500 cycles at 2C under 60°C, and show excellent cycling performance with 97.4% capacity retention (148 mAh g-1) after 30 cycles at 0.1C under 30°C. The composite SPE is also used for high-voltage NCM811||Li half cells. The capacity retention is 63% (99 mAh g-1) after 100 cycles at 0.1C under 60°C. The results imply ZIF-90-g-IL as effective nanofillers for SPEs showing a great potential application in all solid-state lithium metal batteries.

Quality Control of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. HPLC of Formula: 10111-08-7.

Li, Baicun;Zhu, Feifeng;He, Fengming;Huang, Qingqing;Liu, Xiaoguang;Wu, Tong;Zhao, Taige;Qiu, Yingkun;Wu, Zhen;Xue, Yuhua;Fang, Meijuan research published 《 Synthesis and biological evaluations of N’-substituted methylene-4-(quinoline-4-amino)benzoylhydrazides as potential anti-hepatoma agents》, the research content is summarized as follows. In the effort to develop novel quinoline derivatives for the treatment of liver cancer, a series of N’-substituted methylene-4-(quinoline-4-amino)benzoyl hydrazides I (R = n-Pr, 2,6-(MeO)₂C₆H₃, 1H-benzo[d]imidazole-2-yl, etc.) was synthesized and evaluated for their biol. activities as anticancer agents. Compounds I [R = 3,4-dimethoxyphenyl (II), 2,5-dihydroxyphenyl (III)] were found to be the most potent antiproliferative agents against HepG2 cell line with an IC₅₀ value of 12.6 ± 0.1μM and 27.3 ± 1.7μM, resp. Compound II also exhibited potent cytotoxicity against SMMC-7721 and Huh7 cells with IC₅₀ values of 9.6 ± 0.7μM and 6.3 ± 0.2μM, resp. Inspiringly, both II and III exhibited lower cytotoxic property in normal cells than hepatic carcinoma cells. Compounds II and III could down-regulate mRNA level of c-Myc and expression level of c-Myc. Meanwhile, they decreased expression level of anti-apoptotic protein Bcl-2 and increased expression levels of pro-apoptotic protein Bax and cleaved PARP with reference to tubulin. So various assays including cell colony formation, cell cycle distribution, as well as cell apoptosis and migration were performed to understand their antitumor role. It was confirmed that II and III inhibited the growth of HepG2 cells due to their anti-survival effect, induction of cell cycle arrest and cell apoptosis, and inhibition of cell migration. These results demonstrated that II might be a potential lead compound to develop anticancer agents for the treatment of hepatocellular carcinoma.

HPLC of Formula: 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Synthetic Route of 1739-84-0.

Li, Beibei;Xu, Conglei;Yu, Danning;Qi, Ziyuan;Wang, Yifei;Peng, Yongzhen research published 《 Enhanced phosphate remediation of contaminated natural water by magnetic zeolitic imidazolate framework-8@engineering nanomaterials (ZIF8@ENMs)》, the research content is summarized as follows. The efficient enrichment and reutilization of phosphate from natural water still remains a daunting challenge to satisfy the increasingly stringent phosphate discharge criteria. In response to this problem, the presented study successfully synthesizes a series of magnetic zeolitic imidazolate framework-8@engineering nanomaterials (ZIF8@ENMs) via a two-step hydrothermal and coprecipitation method by facilely growing ZIF8 and/or Fe₃O₄ on various functional ENMs. Structure morphol., chem. composition and hysteresis curve characterizations demonstrate the successful formation of magnetic Fe₃O₄-ZIF8@ENM. Amongst the prepared magnetic ZIF8@ENMs hybrids, the Fe₃O₄-ZIF8@ENMs possessing massive hydroxyl groups is demonstrated to harvest the maximum adsorption capacity of 441.7 mg g^-1 under neutral condition. Such-acquired adsorption capacity evidently surpass state-of-the-art adsorbents. Systematic assessment of the chem. condition effects on phosphate removal, revealing its conspicuous merits of robust pH independence (94.63-98.20%), high selectivity pinpointing phosphate within complex cations, ease-of-separation and satisfactory recycle. The outstanding performance of magnetic ZIF8@ENMs are mainly derived from the formed strong Zn-O-P, Fe-O-P and electrostatic interactions between phosphate and adsorbents. Along this line, designing magnetic MOFs-based hybrids towards phosphate are anticipated to be promising avenues for advanced treatment of phosphate-like contaminants and efficient recycle in practical applications.

Synthetic Route of 1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem