288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 288-32-4
The imidazole was weighed into a round-bottomed flask containing 51% anhydrous tetrahydrofuran and shaken for use.Lithium hydride( 168,221] 11] 1 0 1)Under ice-cooling conditions, was slowly added to a solution containing 51] 11 anhydrous tetrahydrofuran.Flask, shake ready; in the ice bath and nitrogen protection conditions, the imidazole solution slowly dropping into the lithium hydride solution, and then 1-Chloro-3-bromopropane (1 mL, 10 mmol) in tetrahydrofuran was slowly added dropwise to the above mixed solution under a nitrogen atmosphere, and 25 C for 24 h. The reaction was quenched by slow addition of distilled water until a clear layer was formed; and the vacuum was distilled at room temperature to remove tetrahydro-Furan; extraction with carbon dioxide (5 X 5 mL), combining organic layers, and evaporation of carbon dioxide to give intermediate 1. Preparation of the middleThe structure was confirmed by 1Hz NMR, 13C NMR. Said intermediate 1 has the following structure:
Statistics shows that 288-32-4 is playing an increasingly important role. we look forward to future research findings about 1H-Imidazole.
Reference:
Patent; Taizhou University; Ying, Anguo; Chen, Gang; Yang, Jianguo; Hou, Hailiang; Hu, Huanan; (11 pag.)CN105439908; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem