Reference of 45676-04-8,Some common heterocyclic compound, 45676-04-8, name is 1-tert-Butylimidazole, molecular formula is C7H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
This ligand was prepared according to a literature method [15] with slight modifications. A mixture of 2,6-dichloropyridine (1.5g, 10mmol) and 1-tert-butylimidazole (5.0g, 40mmol) was heated in an autoclave at 150C for 3 days. Upon cooling, the reaction mixture was dissolved in MeOH (5mL), followed by addition of a large amount of diethyl ether. After filtration, the precipitate was washed with acetone (20mL) and dried to give 2,6-bis(3-tert-butylimidazolium-1-yl)pyridine dichloride as an off-white solid (2.7g, 68%). 1H NMR (CD3CN): delta 10.37 (brs, 2H, NCHN), 8.97 (brs, 2H, imid), 8.58 (t, J=8.1Hz, 1H, 4-py), 8.46 (d, J=8.0Hz, 2H, 3,5-py), 8.36 (brs, 2H, imid), 1.72 (s, 18H, tBu). ESI-MS (m/z): 360.4 [M-Cl]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-tert-Butylimidazole, its application will become more common.
Reference:
Article; Nakamura, Takuo; Ogushi, Shinji; Arikawa, Yasuhiro; Umakoshi, Keisuke; Journal of Organometallic Chemistry; vol. 803; (2016); p. 67 – 72;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem