In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4857-06-1 as follows. name: 2-Chloro-1H-benzo[d]imidazole
2-Chlorobenzimidazole (10 g, 65.56 mmol)was dissolved in 80 ml of 2.5N NaOH (175 mM) and dimethyl sulfate (11.0 mL, 116 mM) wasadded drop wise under stirring at room temperature. After the addition the mixture was stirredfor further 2 h and the precipitate formed was filtered by suction and the product washed severaltimes with ice-water mixture till the filtered solution was neutral. Petrol ether was suckedthrough the solid product several times and then dried in vacuo to afford a light brown solid(8.76 g, 81% yield). 1H NMR (200 MHz, d6-DMSO, delta): 3.78 (s, 3H, CH3), 7.26 (dq, J = 1.2Hz,J = 7.4Hz, BZI-H5/H6), 7.54-7.60 (m, 2H, BZI-H4/H7).
According to the analysis of related databases, 4857-06-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wang, Lei; Kofler, Marina; Brosch, Gerald; Melesina, Jelena; Sippl, Wolfgang; Martinez, Elisabeth D.; Easmon, Johnny; PLoS ONE; vol. 10; 12; (2015);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem