Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives
Step B:; To a solution of 77.1 b (300 mg, 1.01 mmol) in THF (5 ml) was added ‘PrMgCI. LiCI (1 M in THF, 1.3 ml, 1.3 mmol) and stirred at room temperature for 10 min, followed with addition of 77.1c (216 mg, 1.01 mmol). The resulting mixture was stirred overnight, then quenched with saturated aqueous NH4CI, extracted with EtOAc (3 X). The combination of organic layers was washed with brine, dried (Na2SO4), concentrated and purified by flash chromatography to afford product 77.1 as colorless oil (210 mg, 48%). 1H NMR (CDCI3, ppm) 7.39-7.36 (m, 1 H), 7.31-7.25 (m, 3H), 7.20- 7.10 (m, 2H), 7.09-7.02 (m, 4H), 6.44-6.35 (m, 1 H), 6.28-6.20 (m, 1 H), 5.85 (d, 1 H), 3.89 (d, 3H), 2.47 (s, 3H), 1.75-1.70 (m, 3H); MS (ES-LCMS, M+1 ) 434.2. Retention time: 2.55 min.
The synthetic route of 870837-18-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; WO2009/32277; (2009); A1;,
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