Month: November 2022

Iaroshenko, Viktor O. published the artcileTransition-Metal-Catalyzed Arylation of Nitroimidazoles and Further Transformations of Manipulable Nitro Group, Application of 5-Bromo-2-methyl-4-nitroimidazole, the main research area is palladium nickel catalyst arylation nitroimidazole aryl bromide.

Pd- or Ni-catalyzed C-H arylation of 4-nitroimidazole derivatives directed by a manipulable nitro group was developed. The reaction tolerates a wide range of substituted aryl halides and 4-nitroimidazoles. The experiments indicated that the nitro group has influence on the regioselectivity of the reaction. In addition, we have shown that the efficiency of the Suzuki-Miyaura cross-coupling reaction of nitroimidazoles is slightly lower in comparison to the direct C-H arylation. The exploration of the chem. potential of the nitro group and a putative reaction mechanism are discussed.

Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Application of 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wu, Feng published the artcileElectrophilic Fluorination of Imidazoheterocycles by Selectfluor, Safety of Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, the main research area is fluoro imidazoheterocycle preparation; imidazoheterocycle preparation electrophilic fluorination; ethyl bromopyruvate pyridinamine cyclization.

Response surface anal. (RSA) has been used for optimization of the synthesis using selectfluor as a fluorine source and Et imidazo[1,2-a]pyridine-2-carboxylate as a substrate. The latter has been synthesized by cyclization of Me 2-aminopyridine-3-formate with Et bromopyruvate. The optimal reaction conditions have been determined to be as follows: time 3 h, temperature 30°C and selectfluor rate 2.3 equivalent The triplicated verification experiments have led to the average yield of 87%. Four other fluorides of imidazoheterocycles I (R = H, Br; R1 = H, CHO, C(O)OMe; R2 = H, Me, Cl, F; R3 = H, ethoxycarbonyl; X = N, CH) have been synthesized under the optimized conditions.

Russian Journal of General Chemistry published new progress about Aminopyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 67625-38-1 belongs to class imidazoles-derivatives, name is Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, and the molecular formula is C10H9ClN2O2, Safety of Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bhutia, Zigmee T. published the artcileIodine Promoted Efficient Synthesis of 2-Arylimidazo[1,2-a]pyridines in Aqueous Media: A Comparative Study between Micellar Catalysis and an “”On-Water”” Platform, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is aryl methyl ketone aminopyridine iodine micellar catalyst cyclization green; imidazopyridine preparation.

In a new and environmentally sustainable approach, a series of 2-arylimidazo[1,2-a]pyridine derivatives were synthesized in aqueous media in the presence of iodine as a catalyst. The reaction proceeded by condensation of various aryl Me ketones with 2-aminopyridines to afford 2-arylimidazo[1,2-a]pyridines in good overall yields. Although several of the reactions were efficiently performed “”on water””, the addition of a surfactant, namely, sodium dodecyl sulfate , was found effective in terms of substrate scope and yield enhancement. Both methods were successfully used for the gram-scale synthesis of a marketed drug, zolimidine. The simple exptl. setup, water as “”green”” media, and inexpensive catalyst are some of the merits of this protocol.

ACS Omega published new progress about Aminopyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chandra, Tilak published the artcileRegio- and Stereoselective Glycosylation: Synthesis of 5-Halo-Imidazole α-Ribonucleosides, HPLC of Formula: 30086-17-0, the main research area is crystal mol structure haloimidazole nucleoside synthesis stereoselective regioselective glycosylation; stereoselective regioselective glycosylation synthesis halogen imidazole nucleoside synthon cobalamin.

We describe the synthesis of novel 5-halo-imidazole ribonucleosides, e.g. I, as precursors of modified cobalamins. A regio- and stereoselective glycosylation of protected ribose with silylated 4(5)-halo-imidazoles produces 5-halo-imidazole ribonucleosides predominantly in the α-configuration (60-75%) without any 4-substituted imidazole ribonucleoside. The structure of the 5-fluoroimidazole ribonucleoside was confirmed by X-ray crystallog. and 2D NMR spectroscopy.

Journal of Organic Chemistry published new progress about Corrinoids Role: SPN (Synthetic Preparation), PREP (Preparation). 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, HPLC of Formula: 30086-17-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Brown, Tom published the artcilePurines, pyrimidines, and imidazoles. Part 51. New syntheses of some 5-alkyl- and 5-dialkylaminoimidazoles. 3-Alkylimidazolium nucleosides and 3-alkylpurines, Recommanded Product: 5-Amino-1-methyl-1H-imidazole-4-carboxamide, the main research area is imidazolium nucleoside; purine alkyl; Dimroth rearrangement methylaminoimidazolecarboxlate.

The α- and β-anomers of the imidazolium nucleoside I (R = H, R12 = CMe2, R2 = Et) and the β-anomers of I (R = H, R12 = CMe2, R2 = CH2Ph; R = R1 = Ac, R2 = CH2Ph) were prepared by methylation of the corresponding nucleosides with MeI. Their reactions with acids and bases were examined The imidazolecarboxlates II (R = OEt, R1 = H, R2 = Me, CH2Ph) were prepared from EtOC(:NH)CH2CO2Et by substitution with R2NHMe followed by reaction with diazotized PhNH2, reductive formylation, and cyclization. Catalytic hydrogenation of II (R = OEt, R1 = H, R2 = CH2Ph) gave II (R = OEt, R1 = R2 = H) which was converted into 3-methylhypoxanthine ( III; R = H), 3-methylguanine (III; R = NH2), and, by Dimroth rearrangement with aqueous NH3, to II (R = NH2, R1 = Me, R2 = H).

Journal of the Chemical Society, Perkin Transactions 5: Organic and Bio-Organic Chemistry published new progress about Nucleosides Role: SPN (Synthetic Preparation), PREP (Preparation). 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, Recommanded Product: 5-Amino-1-methyl-1H-imidazole-4-carboxamide.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kotla, Siva K. Reddy published the artcileRhodium(III)-catalyzed double C-H activation: a straightforward approach to fused imidazo[1,2-a]pyridines from internal alkynes, Safety of 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is polycyclic imidazopyridine preparation; rhodium catalyst oxidative coupling imidazopyridine internal alkyne.

The Rh(III)-catalyzed oxidative coupling of 2-arylimidazopyridines with internal alkynes via double C-H activation has been described. This approach provides straightforward access to highly functionalized polycyclic imidazopyridines in good to excellent yields. E.g., in presence of [Cp*RhCl2]2, Cu(OAc)2, and Cs2CO3, oxidative coupling of 2-arylimidazo[1,2-a]pyridine (I) with PhCCPh gave 85% 5,6-diphenylnaphtho[1′,2′:4,5]imidazo[1,2-a]pyridine (II).

Tetrahedron Letters published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Safety of 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zaprutko, Lucjusz published the artcileRegioselective nitro group substitution. Synthesis of isomeric 4-amino-5-nitro- and 5-amino-4-nitroimidazoles, Computed Properties of 18874-52-7, the main research area is nitroimidazole cyclic amine regioselective nitro group substitution; imidazolamine nitro preparation.

On the basis of the reactions between 4,5-dinitroimidazoles (1-methyl-, 1,2-dimethyl-, and 1-ethoxycarbonylmethyl-4,5-dinitroimidazole) and cyclic amines (morpholine, piperidine, or pyrrolidine) under mild conditions (THF or EtOH solution), the order of nitro group substitution was discovered. The influence of the solvent, steric effects, and the possibility of hydrogen bond formation on the reaction direction was discussed. Also, the mechanism of formation of a diamino substitution product and an interesting isomerization process were presented.

Heterocycles published new progress about Amines, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Computed Properties of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kumar, G. Santosh published the artcileA copper-catalyzed multi-component reaction accessing fused imidazo-heterocycles via C-H functionalization, Formula: C14H11BrN2, the main research area is pyridone acetophenone copper triflate catalyst microwave irradiation; phenylimidazopyridine preparation multicomponent reaction green chem; thiazole acetophenone copper triflate catalyst microwave irradiation; phenylimidazothiazole preparation multicomponent reaction green chem.

An efficient synthesis of fused imidazo-heterocycles was described using Cu(OTf)2 in [bmim]BF4 by the multi-component reaction of pyridin-2(1H)-one or thiazol/benzo[d]thiazol-2(3H)-ones with O-tosylhydroxyl amine and acetophenones under microwave irradiation The method was very rapid and the product formation occurred via a C-H functionalization/tandem addition-cyclization process. The ionic liquid containing copper triflate was recovered and reused four times.

RSC Advances published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Formula: C14H11BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bodke, Yadav D. published the artcileSynthesis and biological evaluation of imidazo pyridine derivatives containing morpholine nucleus, Related Products of imidazoles-derivatives, the main research area is phenylimidazopyridine morpholinylmethyl preparation antioxidant antifungal antibacterial.

A series of substituted 3-(morpholin-4-ylmethyl)-2-phenylimidazo[1,2-a]pyridine derivatives I (R1 = H, Br, CH3; R2 = H, OCH2C6H5; R3 = Cl, Br, NO2, CN; R4 = H, Cl) were synthesized. The title compounds I were synthesized by the Mannich reaction of imidazo[1,2-a]pyridines derivatives II, morpholine and formaldehyde with catalytic amount of acetic acid at reflux temperature The synthesized compounds I were screened for the antimicrobial and antioxidant activities. From antimicrobial activity results it was found that compounds I (R1 = Br; R2 = H; R3 = Br, CN; R4 = H) displayed very good antibacterial against Staphylococcus aureus and the compound I (R1 = Br; R2 = H; R3 = Br; R4 = H) showed very good antifungal activity against Pseudomonas aeruginosa. Compounds I (R1 = H, CH3; R2 = H, OCH2C6H5; R3 = Cl, CN; R4 = H, Cl) showed promising free radical scavenging activity.

Heterocyclic Letters published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem