Studies of imidazo[1,2-a]benzimidazoles 32. Synthesis and properties of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazol-9(10)-ylacetic acids was written by Anisimova, V. A.;Tolpygin, I. E.;Askalepova, O. I.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2014.Application In Synthesis of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole This article mentions the following:
Reaction of unsubstituted 2,9-dihydro-3H-imidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles with haloacetates afforded the corresponding hetaryl-9(10)-acetates. Subsequent base and acid hydrolysis of these esters yielded the corresponding acids. The zwitterionic structure of the latter was proved. They were also prepared by direct alkylation of unsubstituted N-heterocycles using ClCH2CO2Na or by hydrolysis of the resp. acetonitriles. The synthesized esters readily underwent aminolysis and hydrazinolysis. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Application In Synthesis of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole).
2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem