Acetic Acid Mediated Electrochemical Synthesis of Benzazole and its Application in the Synthesis of Pharmaceutically Active Compounds was written by Ghoshal, Tanay;Patel, Tarun M.;Kotturi, Sharadsrikar. And the article was included in ChemistrySelect in 2021.Application In Synthesis of 1H-Benzimidazole-5-carbaldehyde This article mentions the following:
An acetic acid promoted electrochem. synthesis of benzazoles, benzimidazoles, benzthiazoles and benzoxazoles was reported. The method offered large substrate scope, good functional group tolerance, while using cheap electrolyte. The method use acetic acid as the electrolyte which has a better solubility in methanol, hence the reaction time was less and product formation was observed in high yield without much side product. This electrochem. method was further utilized to synthesize thiabendazole, fuberidazole, chlormidazole and advance intermediates of bilastine and clemizole in good yields. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4Application In Synthesis of 1H-Benzimidazole-5-carbaldehyde).
1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 1H-Benzimidazole-5-carbaldehyde
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem