Asymmetric [3 + 2] Cycloaddition Employing N,N’-Cyclic Azomethine Imines Catalyzed by Chiral-at-Metal Rhodium Complex was written by Gong, Jun;Wan, Qian;Kang, Qiang. And the article was included in Organic Letters in 2018.HPLC of Formula: 85692-37-1 This article mentions the following:
An efficient asym. 1,3-dipolar cycloaddition of α,β-unsaturated 2-acyl imidazoles with N,N’-cyclic azomethine imines catalyzed by a chiral-at-metal rhodium complex is reported. The corresponding N,N’-bicyclic pyrazolidine derivatives with three contiguous tertiary stereocenters, e.g., I, were obtained in good yields (up to 99%) with excellent stereoselectivities (>20:1 dr and >99% ee). Remarkably, as little as 0.5 mol % of a chiral Rh(III) complex can promote a gram-scale reaction with excellent yield and enantioselectivity. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1HPLC of Formula: 85692-37-1).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 85692-37-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem