Iodine-catalyzed oxidative functionalization of purines with (thio)ethers or methylarenes for the synthesis of purin-8-one analogues was written by Zhuge, Juanping;Jiang, Ziyang;Jiang, Wei;Histand, Gary;Lin, Dongen. And the article was included in Organic & Biomolecular Chemistry in 2021.Name: 1-Methylbenzimidazole This article mentions the following:
An efficient oxidative functionalization of purine-like substrates I (R = Et, Bn; R1 = H, Cl; R2 = OMe, Cl) with (thio)ethers such as oxolane, oxane, thiolane, etc. or methylarenes such as methylbenzene, 1,4-dimethylbenzene, ethylbenzene, etc. under mild conditions is described. Using I2 as the catalyst, and TBHP as the oxidant, this protocol provides a valuable synthetic tool for the assembly of a wide range of 9-alkyl(benzyl)purin-8-one derivatives II (R3 = Bn, oxolan-2-yl, thiolan-2-yl, etc.) with high atom- and step-economy and exceptional functional group tolerance. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Name: 1-Methylbenzimidazole).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Name: 1-Methylbenzimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem