Month: February 2023

Determination of quinclorac by adsorptive stripping voltammetry in rice samples without sample pretreatment was written by Liberato, Priscila A.;Okumura, Leonardo L.;Silva, Astrea F. S.;Gurgel, Alexandre;Aleixo, Herbert;Silva, Junio G.;de Oliveira, Andre Fernando. And the article was included in Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes in 2021.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

A novel voltammetric method with practically no sample pretreatment was developed for determination of Quinclorac (QNC) in rice samples by using a working Carbon Paste Electrode (CPE) modified with ionic liquid, with deposition potential (ED) of -1.43 V for 30 s in NaOH 0.01 mol L-1. The systematic influence of cations and anions of imidazole ionic liquids on the composition of CPE has evaluated. The best electrode composition was 65% (weight/weight) of graphite powder, 30% (weight/weight) of mineral oil and 5.0% (weight/weight) of C4min+BF4- ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate). The matrixes analyzed were deionized water and extracts of upland rice: white, brown, peel and seed. The limits of quantification ranged between 0.954 mg kg-1 and 3.61 mg kg-1. The recovery percentages of QNC in rice samples ranged between 90% and 121%. The simplicity and good anal. frequency enable the proposed method to be used to obtain preliminary information on the presence of QNC, prior to the implementation of more detailed, costly and elaborate quant. analyses. The technique can be applied in the study and evaluation of sorption mechanisms, metabolization of the herbicide in plants and its persistence and degradation in the environment. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic synthesis of benzimidazole and its derivatives was written by Kozlov, N. S.;Tovshtein, M. N.. And the article was included in Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk in 1967.Formula: C15H22N2 This article mentions the following:

A new synthesis of the title compounds (I) was described. A mixture of o-O2NC6H4NH2 and the appropriate alc. in the molar ratio 1:3 or 1:6 was passed at a volume speed 0.3 hr.-1 over a catalyst (40 ml.) of V and Cu on Al2O3 heated to 320° and the product filtered off or in the case of excess alc. the solvent was evaporated and the residue fractionated in vacuo to give I (R, m.p. given): H, 170°; Me, 175°; Et, 179°; Pr, 158°; Bu, 148°; amyl, 159°; hexyl, 134°; heptyl, 141°; octyl, 137°; nonyl, 124°; Ph, 290°. Aldehydes formed as by-products could be isolated by distillation or as oximes. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Formula: C15H22N2).

2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Formula: C15H22N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Aqueous Bronsted-Lowry Chemistry of Ionic Liquid Ions was written by Driver, Gordon W.. And the article was included in ChemPhysChem in 2015.Reference of 35487-17-3 This article mentions the following:

Ionic liquids have become commonplace materials found in research laboratories the world over, and are increasingly utilized in studies featuring water as co-solvent. It is reported herein that proton activities, a_H⁺, originating from auto-protolysis of H₂O mols., are significantly altered in mixtures with common ionic liquids comprised of Cl^–, [HSO₄]^–, [CH₃SO₄]^–, [CH₃COO]^–, [BF₄]^–, relative to pure water. Pa_H⁺ values, recorded in partially aqueous media as -log(a_H⁺), are observed over a wide range (âˆ?-13) as a result of hydrolysis (or acid dissociation) of liquid salt ions to their associated parent mols. (or conjugate bases). Bronsted-Lowry acid-base character of ionic liquid ions observed is rooted in equilibrium known to govern the highly developed aqueous chem. of classical organic and inorganic salts, as their well-known aqueous pKs dictate. Classical salt behavior observed for both protic and aprotic ions in the presence of water suggests appropriate attention need be given to relevant chem. systems in order to exploit, or avoid, the nature of the medium formed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Reference of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Complexes of metals with some nitrogen-containing ligands. XX. Complexes of chlorides of Groups III and IV elements with C-carbonyl derivatives of the azole series was written by Garnovskii, A. D.;Kolodyazhnyi, Yu. V.;Alieva, S. A.;Yunusov, K. M.;Popov, I. I.;Osipov, O. A.;Minkin, V. I.;Simonov, A. M.;Grandberg, I. I.. And the article was included in Zhurnal Obshchei Khimii in 1971.Recommanded Product: 3012-80-4 This article mentions the following:

Following ligands dipole moments (calculated from dielec. data in C6H6 at 25°) are tabulated: 2-acetylbenzimidazole, 1.93D (complex with 1 mole TiCl4, m. 67-8°; with 1 mole InCl3 m. 234-5°); 1-methyl-2-acetylbenzimidazole, 2.07D (complex in 2:1 proportion with TiCl4, m. 65-7°; similar complex with InCl3, m. 182°); 1-isopropyl-2-acetylbenzimidazole 2.44D (2:1 complex with SnCl4, m. 144-5°); 2-benzoylbenzimidazole 1.45D (2:1 complex with TiCl4, m. 113-14°; equimolar complex with InCl3, m. 125-6°); 1-methyl-2-formylbenzimidazole 3.37D (equimolar complex with AlCl3, m. 242°; 2:1 complex with InCl3, m. 101-2°; 2:1 complex with SnCl4, m. 148-50°; equimolar complex with AlCl3, m. 59-60°); 2-formylbenzimidazole, 2.84D (equimolar complex with TiCl4, m. 73-4°); 1-phenyl-4-acetylpyrazole, 2.61D (2:1 complex with SnCl4, m. 114-15°); 3,5-dimethyl-4-acetylpyrazole, 2.26D (2:1 complex with SnCl4, m. 68-70°); 1,3,5-trimethyl-4-acetylpyrazole, 2.79D (2:1 complex with SnCl4, m. 49-50°); 1,3,5-trimethyl-4-benzoylpyrazole, 2.80D (2:1 complex with SnCl4, m. 76-7°). The electron d. maps of these were developed from MO calculations of s-cis and s-trans forms of 2-benzothiazoleand 2-N-methylimidazolecarboxaldehydes. In the metal salt complexes listed above the s-trans configuration of the 2-carbonyl derivatives of the benzazole ring series was maintained. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Recommanded Product: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mononuclear silver(I)-N-heterocyclic carbene complexes with benzimidazole-2-ylidene ligands: synthesis, crystal structure analyses and comparative antibacterial studies was written by Mohamed Haziz, Umie Fatihah;Haque, Rosenani A.;Al-Ashraf Abdullah, Amirul;Razali, Mohd R.. And the article was included in Journal of Coordination Chemistry in 2020.SDS of cas: 1632-83-3 This article mentions the following:

The synthesis, characterization and antibacterial studies of N-heterocyclic carbene (NHC) precursors and their resp. Ag(I)-NHC complexes are reported. Five nonsym. benzimidazolium bromide salts were synthesized through the addition of N-alkylbenzimidazole and various alkylbromides. These n-butyl-n’-alkylbenzimidazolium bromide salts (alkyl = Me, Et, pentyl, hexyl, heptyl) , and – were further used as precursors to synthesize Ag(I)-NHC complexes, , and -, resp., via in situ deprotonation. Was synthesized from its reported precursor salt, 1-benzyl-3-butylbenzimidazolium bromide () through the same procedure. Complex is present as monomeric cation as [NHC-Ag-NHC]PF₆, as illustrated by single crystal x-ray crystallog. analyses. In order for a full series of antibacterial studies, 1-butyl-3-propylbenzimidazolium bromide, , and resp. complex, , were synthesized according to the reported procedure. All benzimidazolium salts (-) and Ag(I)-NHC complexes (-) were evaluated for antibacterial activities. All benzimidazolium salts show no antibacterial activities while all Ag(I)-NHC complexes show lower activities against Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 12600) compared to the standard antibiotic drug Amoxicillin. Nevertheless, these mononuclear Ag(I)-NHC complexes show lower antibacterial activities compared to the reported dinuclear Ag(I)-NHC complexes with the same substituents in the ligands. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3SDS of cas: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.SDS of cas: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

(6R,8S)-(2-Benzimidazolyl)hydroxymethylpenicillanic acids as potent antibacterial agents and β-lactamase inhibitors was written by Chen, Yuhpyng L.;Hedberg, Kirk;Guarino, Karen;Retsema, James A.;Anderson, Margaret;Manousos, Mary;Barrett, John. And the article was included in Journal of Antibiotics in 1991.Electric Literature of C9H8N2O This article mentions the following:

(6R,8S)-(2-Benzimidazolyl)hydroxymethylpenicillanic acids I [R = (un)substituted alkyl, alkenyl etc.] (24 compds) are potent antibacterial agents and β-lactamase inhibitors against Gram-pos. bacteria and Haemophilus influenzae. The (6R,8R)-isomers, the 6,6-spirobenzimidazolepenam alc., (7R,9S)-(1-vinyl-2-benzimidazolyl)hydroxymethylcephalosporanic acid, and 6β-(2-benzimidazolyl)aminopenicillanic acid are much less active as antibacterials or β-lactamase inhibitors. The syntheses and structure-activity relationships of these compounds are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Electric Literature of C9H8N2O).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C9H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Acetic Acid Mediated Electrochemical Synthesis of Benzazole and its Application in the Synthesis of Pharmaceutically Active Compounds was written by Ghoshal, Tanay;Patel, Tarun M.;Kotturi, Sharadsrikar. And the article was included in ChemistrySelect in 2021.Application In Synthesis of 1H-Benzimidazole-5-carbaldehyde This article mentions the following:

An acetic acid promoted electrochem. synthesis of benzazoles, benzimidazoles, benzthiazoles and benzoxazoles was reported. The method offered large substrate scope, good functional group tolerance, while using cheap electrolyte. The method use acetic acid as the electrolyte which has a better solubility in methanol, hence the reaction time was less and product formation was observed in high yield without much side product. This electrochem. method was further utilized to synthesize thiabendazole, fuberidazole, chlormidazole and advance intermediates of bilastine and clemizole in good yields. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4Application In Synthesis of 1H-Benzimidazole-5-carbaldehyde).

1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 1H-Benzimidazole-5-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

An expeditious synthesis of benzimidazole derivatives catalyzed by Lewis acids was written by Zhang, Zhan-Hui;Yin, Liang;Wang, Yong-Mei. And the article was included in Catalysis Communications in 2007.Formula: C8H8N2 This article mentions the following:

An expeditious and efficient route for the synthesis of benzimidazole derivatives by the reaction of o-phenylenediamines with orthoesters in the presence of Lewis acids was described. ZrCl₄, SnCl₄.5H₂O, TiCl₄, BF₃.Et₂O, ZrOCl₂.8H₂O and HfCl₄ exhibited high catalytic activity for this transformation. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Formula: C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A versatile synthesis of pyrazolo[3,4-c]isoquinoline derivatives by reaction of 4-aryl-5-aminopyrazoles with aryl/heteroaryl aldehydes: the effect of the heterocycle on the reaction pathways was written by Bogza, Sergei L.;Kobrakov, Konstantin I.;Malienko, Anna A.;Perepichka, Igor F.;Sujkov, Sergei Yu.;Bryce, Martin R.;Lyubchik, Svetlana B.;Batsanov, Andrei S.;Bogdan, Natalya M.. And the article was included in Organic & Biomolecular Chemistry in 2005.Reference of 3012-80-4 This article mentions the following:

The reaction of 4-(3,4-dimethoxyphenyl)-5-aminopyrazoles I (R¹ = Me, Et, Ph, PhCH₂) with aromatic and heterocyclic aldehydes R²CHO (R² = Ph, 3-ClC₆H₄, 4-Et₂NC₆H₄, 3-pyridyl, 2-quinolinyl, 1,2,3-thiadiazol-5-yl) in strong acidic media (trifluoroacetic or formic acid) produced the intermediate pyrazolyl azomethines, which undergo cyclization, similar to the Pictet-Spengler condensation, to give, after in situ aromatization, 5-aryl(heteroaryl)-pyrazolo[3,4-c]isoquinolines II. Whereas for benzaldehyde and its derivatives this one-pot synthesis presents a convenient general route to 5-aryl-pyrazolo[3,4-c]isoquinolines II, in the case of heterocyclic aldehydes the product structure varies markedly with the structure of the aldehyde used: (i) 3-pyridyl-, 3-quinolyl-, 3-thienyl-, and 1,2,3-thiadiazolyl-5-carboxaldehydes give pyrazolo[3,4-c]isoquinolines II; (ii) 1-methylbenzimidazolyl-2-carboxaldehyde gives only intermediate azomethine, which does not cyclize; (iii) 1-R³-3-indolylcarboxaldehydes (R³ = H, Me, PhCH₂) eliminate the heteroaryl fragment resulting in 5-unsubstituted pyrazolo[3,4-c]isoquinolines II (R² = H). Thienyl-2-carboxaldehyde reacts by both pathways (i) and (iii) depending on the reaction conditions. The single crystal X-ray structures for II (R¹ = Me, R² = 2-thienyl; R¹ = PhCH₂, R² = 4-Et₂NC₆H₄; R¹ = Me, R² = H) provide confirmation of the different types of products formed in these reactions. Mechanisms which explain these transformations are presented. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Reference of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquid modification of graphene oxide and its role towards controlling the porosity, and mechanical robustness of polyurethane foam was written by Mondal, Titash;Basak, Suman;Bhowmick, Anil K.. And the article was included in Polymer in 2017.Formula: C4H7ClN2 This article mentions the following:

1-Me imidazole chloride ionic liquid grafted graphene oxide (G[MIM]Cl) was synthesized and utilized as an effective agent for controlling the strength, distribution and dimension of the pores of polyurethane foam system (ILF). Polymeric foams fabricated with pristine expandable graphite (GF) and the neat polymer (PUF) demonstrated a distorted cell structure and an uneven distribution of the pores. Addnl., the mech. properties of GF and PUF were found to be inferior compared to those of ILF. The effect of surface modification of filler on the dispersion in the polyurethane matrix was also studied and compared with the dispersion of the unfunctionalized filler. The ILF exhibited higher elec. conductivity over the GF and the PUF. Compressive stress-strain behavior and dynamic mech. properties indicated that ILF demonstrated significant mech. robustness compared to GF and PUF. These findings can be readily extended to the development of complex three dimensional polymeric architecture where controlled porosity is required. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem