Month: February 2023

Discovery of ONO-8590580: A novel, potent and selective GABA_A α₅ negative allosteric modulator for the treatment of cognitive disorders was written by Lewis, A.;Beresford, A.;Chambers, M. S.;Clark, G.;Hartley, D. C.;Hirst, K. L.;Higashino, M.;Kawahadara, S.;Nakanishi, M.;Saito, T.;Imagawa, A.;Habashita, H.;Maidment, S.;Macleod, A. M.;Owens, A. P.;Rae, A.;Rouse, C.;Wishart, G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Related Products of 25676-75-9 This article mentions the following:

The identification and SAR development of a series of neg. allosteric modulators of the GABA_A α5 receptor is described. This novel series of compounds was optimized to provide analogs with high GABA_A α5 binding affinity, high α5 neg. allosteric modulatory activity, good functional subtype selectivity and low microsomal turnover, culminating in identification of ONO-8590580(I). In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Related Products of 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Related Products of 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole-containing bispidine ligands: synthesis, structure and Cu(II) complexation was written by Walther, Martin;Matterna, Madlen;Juran, Stefanie;Faehnemann, Silke;Stephan, Holger;Kraus, Werner;Emmerling, Franziska. And the article was included in Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences in 2011.Recommanded Product: (1H-Imidazol-2-yl)methanamine dihydrochloride This article mentions the following:

The preparation and characterization of tris-pyridyl bispidine (3,7-diazabicyclo[3.3.1]nonane) derivatives with benzimidazole and imidazole donor groups at the N-3 position of the bispidine skeleton and their copper(II) complexes are reported. The impact of the hetaryl substituents on the configurational isomerism of piperidones and their corresponding bispidones was studied by NMR spectroscopy, revealing the exclusive appearance in the enol form for the piperidones in solution and the trans-configuration regarding the two pyridyl substituents, as well as the sole formation of the unsym. exo-endo isomers for the corresponding bispidones. Thus, the bispidones are preorganized ligands for building pentacoordinated complexes, confirmed by the preparation and characterization of the corresponding Cu(II) complexes. Of the di-pyridyl piperidones with benzimidazole and imidazole substituents, and of the Cu(II) complex of the benzimidazole-containing bispidone, crystals have become available for the anal. by x-ray diffraction, showing that the piperidones form the enol tautomers also in the solid state. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7Recommanded Product: (1H-Imidazol-2-yl)methanamine dihydrochloride).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: (1H-Imidazol-2-yl)methanamine dihydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem