Synthetic Route of 3034-38-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3034-38-6, name is 5-Nitro-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
In a 25 ml round bottom flask is added 4 – nitroimidazole (0.052 g, 0 . 461 mmol), potassium carbonate (0.152 g, 1 . 10 mmol), for 10 ml b the nitrile does solvent 60 C under stirring 1 hour later, adding imidazole and benzo thiazole derivatives VI – 6 (0.2 g, 0 . 423 mmol), continue to 60 C under stirring reaction, thin-layer chromatography tracking until a reaction is finished. Removing the acetonitrile is distilled under reduced pressure, then the saturated salt water and chloroform extraction, concentrate, column chromatography, recrystallization, post-treatment such as drying to obtain compound II – 6 (0.176 g), yield 83.0%; white solid
The synthetic route of 5-Nitro-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Southwest University; Zhou Chenghe; Ma Dili·siweita·kaweisiwarui; Li Zhenzhen; (24 pag.)CN108383859; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem