Bhutia, Zigmee T. published the artcileIodine Promoted Efficient Synthesis of 2-Arylimidazo[1,2-a]pyridines in Aqueous Media: A Comparative Study between Micellar Catalysis and an “”On-Water”” Platform, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is aryl methyl ketone aminopyridine iodine micellar catalyst cyclization green; imidazopyridine preparation.
In a new and environmentally sustainable approach, a series of 2-arylimidazo[1,2-a]pyridine derivatives were synthesized in aqueous media in the presence of iodine as a catalyst. The reaction proceeded by condensation of various aryl Me ketones with 2-aminopyridines to afford 2-arylimidazo[1,2-a]pyridines in good overall yields. Although several of the reactions were efficiently performed “”on water””, the addition of a surfactant, namely, sodium dodecyl sulfate , was found effective in terms of substrate scope and yield enhancement. Both methods were successfully used for the gram-scale synthesis of a marketed drug, zolimidine. The simple exptl. setup, water as “”green”” media, and inexpensive catalyst are some of the merits of this protocol.
ACS Omega published new progress about Aminopyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Name: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem