Adding a certain compound to certain chemical reactions, such as: 1008361-65-6, name is 5-Bromo-6-methoxy-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1008361-65-6, Product Details of 1008361-65-6
Compound 5-bromo-6-methoxy-1H-benzimidazole 60d (430.0 mg, 1.9 mmol), triethylamine (383.0 mg,3.8 mmol) and 4-dimethylaminopyridine (23.0 mg, 0.2 mmol)With tetrahydrofuran (15.0 mL)After mixing, di-tert-butyl dicarbonate (585.0 mg, 2.9 mmol) was added at room temperature, and the reaction was carried out at 45 C for 12 hours.The reaction solution was diluted with methylene chloride (100 mL) and washed with brine. The organic phase is dried over anhydrous sodium sulfate and filtered to dissolve to give a mixture of 1-t-butoxy acyl-5-Bromo-6-methoxy-benzimidazole 60e and 3-tert-butoxycarbonyl-5-bromo-6-methoxy-benzimidazole 61e (450.0 mg,1.4 mmol, white solid), yield 73%.
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Reference:
Patent; Nanjing Tianyinjianhua Pharmaceutical Technology Co., Ltd.; Kong Xianglong; Zhou Chao; Zheng Zhixiang; (105 pag.)CN109020957; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem