Category: imidazoles-derivatives

Recommanded Product: 65039-09-0《Highly efficient absorption of HCl in deep eutectic solvents and their corresponding ethylene glycol blends》 was published in 2022. The authors were Pan, Yi;Liu, Yu;Tu, Zhuoheng;Zhang, Xiaomin;Wu, Youting;Hu, Xingbang, and the article was included in《Chemical Engineering Journal (Amsterdam, Netherlands)》. The author mentioned the following in the article:

Effective separation of byproduct HCl is of great importance for its recovery and high-value utilization. Herein, a novel strategy for highly efficient and reversible absorption of HCl using deep eutectic solvents (DESs) and their corresponding ethylene glycol blends (DES/EG blends) was reported. HCl uptakes (up to 0.881 g/g) higher than that of water (0.67 g/g) were achieved. The d., viscosity, thermal decomposition temperatures, m.ps. and the HCl uptakes (0-1.0 bar, 293.2-328.2 K) of DESs or DES/EG blends were systematically determined Almost pure HCl (greater than 99.5%) could be easily stripped out at elevated temperature and reduced pressure. Spectroscopic characterizations paired with theor. calculations were applied to characterize the interaction mechanism of HCl in DESs or DES/EG blends. It is the densified hydrogen bond networks in DESs or DES/EG blends that can lower the energy level of systems and induce the superior absorption of HCl. This work provides novel insights into high-performance DESs or DES/EG blends for the absorption of HCl. To complete the study, the researchers used 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Recommanded Product: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivatives《A fluorescent chemosensor for the sequential detection of copper(II) and histidine and its biological applications》 was published in 2016. The authors were Wang, Dan;Zheng, Jian-Quan;Zheng, Xiang-Jun;Fang, De-Cai;Yuan, Da-Qiang;Jin, Lin-Pei, and the article was included in《Sensors and Actuators, B: Chemical》. The author mentioned the following in the article:

A new fluorescent sensor 6-(2,3-dihydroxyphenyl)-5,6-dihydrobenzoimidazo[1,2-c] quinazoline (H₂L) and the Zn(II) complex [Zn₂L¹2]·C₂H₅OH (H₂L¹ = 3-{[2-(1H-benzoimidazol-2-yl)-phenylimino]-methyl}-benzene-1,2-diol) (1) were synthesized and characterized by single-crystal X-ray diffraction. H₂L can be used to recognize Cu²⁺ in aqueous media as an on-off fluorescent sensor, forming the Cu(II) Schiff-base complex (CuL¹). Furthermore, CuL¹ can serve as an off-on fluorescent sensor to detect histidine (His) via the ligand displacement approach. The sequential detection of Cu(II) and histidine shows on-off-on phenomenon. The crystal structure of the dinuclear Zn(II) complex indicates that the coordination of H₂L with Zn(II) promotes C-N bond breakage, resulting in the quinazoline ring-opening of H₂L to form the Zn(II) Schiff-base complex (1). The exptl. results proved that H⁺ can also assist the ring-opening of H₂L to form a Schiff base, H₂L¹. H₂L is stable in neutral and weak basic solutions This is further confirmed by the theor. calculations The cell imaging studies indicated that H₂L and CuL¹ can be used to detect the intracellular Cu²⁺ ion and His under physiol. conditions, resp. CuL¹ can also be used to determine His in urine. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Category: imidazoles-derivatives) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kiefer, Rudolf;Elhi, Fred;Puust, Laurits;Peikolainen, Anna-Liisa;Tamm, Tarmo published 《Dual function composite fibers of cellulose with activated carbon aerogel and carbide derived carbon》. The research results were published in《Journal of Applied Polymer Science》 in 2022.HPLC of Formula: 65039-09-0 The article conveys some information:

Polymers of natural origin, especially cellulose, have risen to the focus of smart materials, and also energy storage materials’ research as sustainable matrix alternatives. In this work, novel composites of cellulose with activated carbon aerogel (ACA) and carbide-derived carbon (CDC) are demonstrated. The composites were formulated as fibers from regenerated cellulose (Cell). The electromech. response as linear actuation in stress and strain of the fibers was studied in an organic electrolyte at low applied potentials in range of 0.55 to -0.8 V. Cyclic voltammetry and square wave potential steps were performed revealing for both composite fibers expansion at pos. charging. The Cell-ACA fibers showed a stronger response compared with Cell-CDC, largely due to the particle structure, reflected in higher electronic conductivity The chronopotentiometric measurements showed that Cell-ACA also had the higher specific capacitance of the two of 47.5 F g^-1. The dual-function of Cell-ACA and Cell-CDC of electromech. activity and energy storage capability can have potential in smart clothing applications. The experimental procedure involved many compounds, such as 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.HPLC of Formula: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kravtsov, Dmytro published 《Oxidation of some benzyl substituted fused quinazoline derivatives》 in 2019. The article was appeared in 《Organic Communications》. They have made some progress in their research.Recommanded Product: 5805-39-0 The article mentions the following:

In this study, synthesis of some benzoyl substituted fused quinazoline derivatives e.g., I, using Fieser’s reagent, was reported. An unexpected product fused quinazolinone and BzOH were isolated from the reaction mixture Based on the exptl. data, a possible oxidation mechanism of ketone I with chromium trioxide was described. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

de Sousa, Kenia Marcatti;Lima, Thailan Souza Pereira;de Souza, Ranyere Lucena;Nerli, Bibiana Beatriz;Pereira, Matheus M.;Soares, Cleide Mara Faria;Lima, Alvaro Silva published 《Liquid-liquid equilibrium data for the ternary system based on ionic liquid + organic solvents + water at 298 K and atmospheric pressure applied in antidepressant partitioning》. The research results were published in《Separation and Purification Technology》 in 2022.HPLC of Formula: 65039-09-0 The article conveys some information:

Antidepressants are drugs widely used in nervous disorders, such as anxiety, depression, and panic, and are eliminated through the urinary system. In bodies of water, they present high persistence and toxicity, even at low concentrations, conforming to the classification of emerging micropollutants. This work addresses the construction of phase diagrams for different biphasic systems, based on ionic liquids (ILs) and organic solvents, and their subsequent application in the partitioning of antidepressants such as fluoxetine hydrochloride, paroxetine hydrochloride and sertraline hydrochloride. The phase diagrams were measured gravimetrically at 298.15 ± 1.00 K and atm. pressure using the turbidity method. The ILs of the imidazolium family, with shorter chain length [C₂mim]⁺, were the only ones able to form biphasic systems using 1,3-dioxolane. The driving force for phase separation is the comparison of hydrophobic/hydrophilic characteristics between the constituents. In this sense, the pair of constituents [C₂min][OAc] and 1,3-dioxolane provided the phase diagram with the largest biphasic area. The partitioning of antidepressants was studied in systems formed by IL (25%) + 1,3-dioxolane (50%) + water (25%) containing 1.05μg·L^-1 of fluoxetine hydrochloride, 1.42μg·L^-1 of paroxetine hydrochloride or 0.23μg·L^-1 sertraline hydrochloride at 298.15 ± 1.00 K and atm. pressure. The partitioning followed the characteristics of antidepressant σ-profiles generated through COSMO-RS. The recoveries were high, and the proposed systems were shown to promote the selective isolation of pairs of these antidepressants. To complete the study, the researchers used 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.HPLC of Formula: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Doelle, Anja;Adhikari, Bikash;Kraemer, Andreas;Weckesser, Janik;Berner, Nicola;Berger, Lena-Marie;Diebold, Mathias;Szewczyk, Magdalena M.;Barsyte-Lovejoy, Dalia;Arrowsmith, Cheryl H.;Gebel, Jakob;Loehr, Frank;Doetsch, Volker;Eilers, Martin;Heinzlmeir, Stephanie;Kuster, Bernhard;Sotriffer, Christoph;Wolf, Elmar;Knapp, Stefan published 《Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders》. The research results were published in《Journal of Medicinal Chemistry》 in 2021.Electric Literature of C6H7BrN2 The article conveys some information:

Histone H3K4 methylation serves as a post-translational hallmark of actively transcribed genes and is introduced by histone methyltransferase (HMT) and its regulatory scaffolding proteins. One of these is the WD-repeat-containing protein 5 (WDR5) that has also been associated with controlling long noncoding RNAs and transcription factors including MYC. The wide influence of dysfunctional HMT complexes and the typically upregulated MYC levels in diverse tumor types suggested WDR5 as an attractive drug target. Indeed, protein-protein interface inhibitors for two protein interaction interfaces on WDR5 have been developed. While such compounds only inhibit a subset of WDR5 interactions, chem. induced proteasomal degradation of WDR5 might represent an elegant way to target all oncogenic functions. This study presents the design, synthesis, and evaluation of two diverse WDR5 degrader series based on two WIN site binding scaffolds and shows that linker nature and length strongly influence degradation efficacy.2-Bromo-5H,6H,7H-pyrrolo[1,2-a]imidazole (cas: 1525619-20-8) were involved in the experimental procedure.

Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Electric Literature of C6H7BrN2Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wong, John L.;Fuchs, David S. published 《Reactivities and electronic aspects of nucleic acid heterocycles. III. Hydrolytic behavior of 6-methoxypurines》 in 1974. The article was appeared in 《Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999)》. They have made some progress in their research.Formula: C7H11N3O2 The article mentions the following:

Aqueous acidic hydrolysis of the methoxypurine I (0.1M) gave Me 5-amino-1-methylimidazole-4-carboxylate and 9-methylhypoxanthine (7:3). II and III behaved analogously. At >0.2M concentrations of the methoxypurines, O to N methyl migration became competitive. The hydrolysis proceeded via purine dications. The results indicated that no O-methylated pyrimidines or purines could survive the acidic conditions used prevalently in the chem. hydrolysis of nucleic acids. And Ethyl 5-amino-1-methyl-1H-imidazole-4-carboxylate (cas: 54147-04-5) was used in the research process.

Ethyl 5-amino-1-methyl-1H-imidazole-4-carboxylate (cas: 54147-04-5 Formula: C7H11N3O2) is a synthetic retinoid that has been shown to be effective in the treatment of psoriasis. It inhibits the activation of histone lysine residues and increases the terminal half life of endogenous synthesis.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of C6H11ClN2In 2022, Elterman, V. A.;Shevelin, P. Yu.;Yolshina, L. A.;Borozdin, A. V. published 《Features of aluminum electrodeposition from 1,3-dialkylimidazolium chloride chloroaluminate ionic liquids》. 《Journal of Molecular Liquids》published the findings. The article contains the following contents:

The mechanism of aluminum electrodeposition from acidic 1-butyl-3-methylimidazolium chloride chloroaluminate ionic liquids ([BMIm]Cl ILs) is studied over a wide range of the molar ratio of AlCl₃ to [BMIm]Cl (N) at 30°C. The findings for AlCl₃-[BMIm]Cl and AlCl₃-1-ethyl-3-methylimidazolium chloride ([EMIm]Cl) are analyzed and compared in order to identify dependences common for 1,3-dialkylimidazolium chloride ILs. Limiting currents were detected on the cathodic polarization curves at the aluminum | ionic liquid interface. Limiting currents are caused by the Al₂Cl^–₇ anions diffusion to the electrode surface. The limiting c.d. values for AlCl₃-[BMIm]Cl are lower (i_lim, 1.1 ≤ N leq 2.0 = 1.17 – 12.36 mA•cm^-2) than for AlCl₃-[EMIm]Cl (i_lim, 1.1 ≤ N leq 2.0 = 1.81 – 25.37 mA·cm^-2). It is shown that anion AlCl-4 can be reduced to metallic aluminum at cathodic overpotentials above 1.5 V. The diffusion coefficient of Al₂Cl-7 in AlCl₃-[BMIm]Cl (7.4•10-7 cm²•s^-1) is lower than in AlCl₃-[EMIm]Cl (9.3•10-7 cm²•s^-1) and is unaffected by aluminum chloride concentration in either system. The experimental procedure involved many compounds, such as 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Synthetic Route of C6H11ClN2

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline《Molecular design of amino-type hydrogen-bonding molecules for excited-state intramolecular proton transfer (ESIPT)-based fluorescent probe using the TD-DFT approach》 was published in 2021. The authors were Kanlayakan, Narissa;Kungwan, Nawee, and the article was included in《New Journal of Chemistry》. The author mentioned the following in the article:

A mol. screening has been carried out for fluorescent probes harnessing excited-stated intramol. proton transfer (ESIPT) of NH-type mols. having aminophenyl or tosylaminophenyl as a proton donor and benzimidazole, benzoxazole, benzothiazole, or imidazo[1,2-a]pyridine as a proton acceptor with different substituents using time-dependent d. functional theory. Among the designed ESIPT mols., 2-(2′-tosylaminophenyl)benzimidazole, 2-(2′-tosylaminophenyl)benzothiazole, and 2-(2′-tosylaminophenyl)imidazo[1,2-a]pyridine with dimethylamino in the tosylaminophenyl and/or cyano in the benzimidazole, benzothiazole, and imidazo[1,2-a]pyridine, resp., were revealed to be the best five candidates because they passed the screening requirements, including photophys., kinetics, and thermodn. parameters. Here, these five candidates required less photo-absorption around 380 nm and emitted the tautomer peaks in the near IR (NIR) region, leading to large Stokes shifts (~200 nm) with no self-reabsorption, which are important characteristics for fluorescent probes. The NIR emission is caused by the intramol. charge-transfer character of the strong electron-donating dimethylamino in the tosylaminophenyl moiety and heteroatoms in the benzimidazole/benzothiazole/imidazo[1,2-a]pyridine moiety as evidenced by the electron-d. differences and frontier MOs. In addition, they exhibit high photo-acidity and photo-basicity (low PT barrier with highly exothermic) to warrantee the ESIPT. Therefore, the obtained screening information in this work could be beneficial for designing new ESIPT fluorescent-based probes. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Song, Xiangbo;Liao, Yuhe;Liu, Tingsen;Yin, Dedu;Wang, Haiyong;Chen, Lungang;Ma, Longlong;Yang, Hongwei;Voskressensky, Leonid G.;Wang, Chenguang published 《A highly effective approach to enhance the performance of biomass-derived acid for fructose conversion to 5-hydroxymethylfurfural》. The research results were published in《Fuel Processing Technology》 in 2022.Recommanded Product: 65039-09-0 The article conveys some information:

Synthesis of 5-hydroxymethylfurfural (HMF) from carbohydrate is one of vital step for bio-refinery development. In this work, a novel strategy was developed for catalytic conversion of fructose to HMF in 2-butanol. The inexpensive ionic liquids were used to adjust the acidity of biobased acid catalyst for enhancing the dehydration of fructose to HMF. The combination of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) with oxalic acid afforded an excellent HMF yield of 97.1% at 98.7% fructose conversion under mild conditions of 100°C and 60 min, owing to the enhanced dissociation ability of oxalic acid by [Bmim]Cl. A possible dissociation mechanism of oxalic acid induced by [Bmim]Cl was proposed based on control experiments and detailed analyses with NMR and FT-IR techniques. It involved that the [Bmim]Cl interacted with oxalic acid through hydrogen bond, which decreased the electron d. of oxygen atom on hydroxyl group and weakened the O-H bond, thus making the hydrogen in the O-H group to easily dissociate in the form of H⁺. Moreover, the reusability of oxalic acid and [Bmim]Cl was demonstrated, and both could be reused up to six times without significant loss in activity. To complete the study, the researchers used 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Recommanded Product: 65039-09-0

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem