Imidazoles-derivatives

Thermal behavior analysis as a valuable tool for comparing ionic liquids of different classes was written by Mezzetta, Andrea;Perillo, Vincenzo;Guazzelli, Lorenzo;Chiappe, Cinzia. And the article was included in Journal of Thermal Analysis and Calorimetry in 2019.SDS of cas: 21252-69-7 This article mentions the following:

The thermal behavior of I [R = H, Br; X = Br, NTf₂; n = 2, 6; m = 1, 4] and II ILs, belonging to two structurally related families with either bromide or Tf₂N as counteranion, was analyzed. For bromide mono- I and dicationic ionic liquids II (DILs), thermal gravimetric anal. showed similar decomposition events, with only small gain in stability for a few members of the latter class. Conversely, all Tf₂N DILs displayed higher stabilities (up to 34 K) than the corresponding monocations, thus highlighting the different role played by the two counteranions. Mono- and dicationic ILs bearing a reactive group on the imidazolium substituent resulted instead the least stable ILs studied. Differential scanning calorimetry anal. of most of the (D)ILs only showed glass transition temperatures, a behavior in agreement with the broad liquid range of ILs. The impact of the cationic structure and/or of the type of anion on the above-mentioned transition temperatures were studied. The apparent activation energy (Ea) and the fragility index (m) for some (D)ILs had also been obtained. Finally, a few bromide (D)ILs presented peculiar thermal events. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7SDS of cas: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.SDS of cas: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

peri-Substituted imidazo[1,2-a]pyridines. A new reductive elimination reaction was written by Rees, Charles W.;Smith, David I.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.SDS of cas: 88047-55-6 This article mentions the following:

A new reductive elimination reaction of 3,5-disubstituted imidazo[1,2-a]pyridines I (R, R¹ = Br, NO₂) with N₂H₄ in hot EtOH is reported. A mechanism based on the conjugated relationship of these peri-substituents is proposed and used to explain the reported conversion of 1,3,5-trichloro-2,4,6-trinitrobenzene into 1,3-dichloro-4,6-dinitrobenzene. A variety of other 3-nitro-5-substituted imidazo[1,2-a]pyridines I (R = NO₂, R¹ = CO₂Me, CONHNH₂, CON₃, NH₂, NHCO₂Me, N₃, etc.) are described, but these could not be cyclized. The 3-amino-5-methoxycarbonyl derivative I (R = NH₂, R¹ = CO₂Me) cyclizes to the imidazoindazole II with NaOMe. In the experiment, the researchers used many compounds, for example, Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6SDS of cas: 88047-55-6).

Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 88047-55-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enthalpy characteristics of mononitro derivatives heterocyclic compounds was written by Kostikova, L. M.;Miroshnichenko, E. A.;Matyushin, Y. N.;Vorob’ev, A. B.;Inozemtcev, J. O.. And the article was included in International Annual Conference of ICT in 2002.Synthetic Route of C4H5N3O2 This article mentions the following:

The enthalpies of formation in the standard condition and gas phase some mononitro derivatives heterocyclic compounds are exptl. determined The cleanliness of some compounds is measured by the method of the curve melting. The substances burnt in the solution of the di-Me phthalate for prevention of explosion and ensuring of completeness of combustion. The thermal effect of reaction of dissolution of substances in the di-Me phthalate is measured on the microcalorimeter and it was taken into account at calculation of the enthalpy of formation of the studied compounds Efficient energies of introduction nitro groups in the heterocycles are found. The change of the enthalpy of formation at introduction of electroneg. fragments to atoms of carbon and nitrogen is analyzed. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Synthetic Route of C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quaternization of azido-N-heteroarenes with Meerwein reagent: A straightforward synthesis of 2-azido(benzo)imidazolium and related azido-N-heteroarenium tetrafluoroborates was written by Li, Yan;Wan, Ting-Biao;Guo, Bin;Qi, Xiao-Wen;Zhu, Chifan;Shen, Mei-Hua;Xu, Hua-Dong. And the article was included in Tetrahedron Letters in 2022.Synthetic Route of C8H8N2 This article mentions the following:

The 2-azido(benzo)imidazolium salts e.g., I have been made through quaternization of 2-Azido(benzo)imidazoles e.g., II with Meerwein reagent at ambient conditions. This one-pot protocol is also applicable to 4 or 3-azidopyridines e.g., III and appropriate azido(iso)quinolines e.g., IV to prepare correlative azido-N-heteroarenium salts e.g., I. When compared with their precursors, improved diazotransfer reactivity was observed for several representative azido-N-heteroarenium salts e.g., I in reaction with di-Et malonate. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Synthetic Route of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of ONO-8590580: A novel, potent and selective GABA_A α₅ negative allosteric modulator for the treatment of cognitive disorders was written by Lewis, A.;Beresford, A.;Chambers, M. S.;Clark, G.;Hartley, D. C.;Hirst, K. L.;Higashino, M.;Kawahadara, S.;Nakanishi, M.;Saito, T.;Imagawa, A.;Habashita, H.;Maidment, S.;Macleod, A. M.;Owens, A. P.;Rae, A.;Rouse, C.;Wishart, G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Related Products of 25676-75-9 This article mentions the following:

The identification and SAR development of a series of neg. allosteric modulators of the GABA_A α5 receptor is described. This novel series of compounds was optimized to provide analogs with high GABA_A α5 binding affinity, high α5 neg. allosteric modulatory activity, good functional subtype selectivity and low microsomal turnover, culminating in identification of ONO-8590580(I). In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Related Products of 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Related Products of 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole-containing bispidine ligands: synthesis, structure and Cu(II) complexation was written by Walther, Martin;Matterna, Madlen;Juran, Stefanie;Faehnemann, Silke;Stephan, Holger;Kraus, Werner;Emmerling, Franziska. And the article was included in Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences in 2011.Recommanded Product: (1H-Imidazol-2-yl)methanamine dihydrochloride This article mentions the following:

The preparation and characterization of tris-pyridyl bispidine (3,7-diazabicyclo[3.3.1]nonane) derivatives with benzimidazole and imidazole donor groups at the N-3 position of the bispidine skeleton and their copper(II) complexes are reported. The impact of the hetaryl substituents on the configurational isomerism of piperidones and their corresponding bispidones was studied by NMR spectroscopy, revealing the exclusive appearance in the enol form for the piperidones in solution and the trans-configuration regarding the two pyridyl substituents, as well as the sole formation of the unsym. exo-endo isomers for the corresponding bispidones. Thus, the bispidones are preorganized ligands for building pentacoordinated complexes, confirmed by the preparation and characterization of the corresponding Cu(II) complexes. Of the di-pyridyl piperidones with benzimidazole and imidazole substituents, and of the Cu(II) complex of the benzimidazole-containing bispidone, crystals have become available for the anal. by x-ray diffraction, showing that the piperidones form the enol tautomers also in the solid state. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7Recommanded Product: (1H-Imidazol-2-yl)methanamine dihydrochloride).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: (1H-Imidazol-2-yl)methanamine dihydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives was written by Bellina, Fabio;Biagetti, Matteo;Guariento, Sara;Lessi, Marco;Fausti, Mattia;Ronchi, Paolo;Rosadoni, Elisabetta. And the article was included in RSC Advances in 2021.COA of Formula: C8H8N2 This article mentions the following:

A variety of 2-alkynyl(benzo)imidazoles I (R = Ph, n-hexyl, 2-chlorophenyl, etc.; R¹ = R² = H; R¹R² = -CH=CH-CH=CH-) have been synthesized by dehydrogenative alkynation of N-methylimidazole or 1-methyl-1H-1,3-benzodiazole with terminal alkynes RCCH in NMP under air in the presence of Ag₂CO₃ as the oxidant and Pd(OAc)₂ as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrospun nylon 6 nanofibers incorporated with 2-substituted N-alkylimidazoles and their silver(I) complexes for antibacterial applications was written by Kleyi, Phumelele;Frost, Carminita L.;Tshentu, Zenixole R.;Torto, Nelson. And the article was included in Journal of Applied Polymer Science in 2014.Application of 21252-69-7 This article mentions the following:

The article presents the incorporation of biocides [2-substituted N-alkylimidazoles and their silver(I) complexes] into electrospun nylon 6 nanofibers for application as antimicrobial materials. The electrospun nylon 6/biocides nanofiber composites were characterized by IR spectroscopy (ATR-FTIR) and SEM (SEM-EDX). The antimicrobial activity of the electrospun nylon 6/biocides nanofiber composites was evaluated against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis subsp. spizizenii using the disk diffusion method, the American Association for Textile Chemists and Colorists test method 100-2004 and the dynamic shake flask method (American Society for Testing and Materials E2149-10). The electrospun nylon 6 nanofibers incorporated with 2-substituted N-alkylimidazoles displayed moderate to excellent levels of growth reduction against S. aureus (73.2-99.8%). For the electrospun nylon 6 nanofibers incorporated with silver(I) complexes, the levels of growth reduction were >99.99%, for both E. coli and S. aureus, after the antimicrobial activity evaluation using the shake flask method. The study demonstrated that the electrospun nanofibers, fabricated using the incorporation strategy, have the potential to be used as attractive antimicrobial materials. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrophilic properties of nitroheterocyclic compounds. was written by Zieba-Mizgala, Anna;Puszko, Aniela;Regiec, Andrzej;Kuduk-Jaworska, Janina. And the article was included in Bioelectrochemistry in 2005.Reference of 3034-41-1 This article mentions the following:

Investigation of the reduction potential and calculation of the partition coefficient n-octanol/water allow the assessment of the potential suitability of nitropyridine N-oxide compounds in radiotherapy of cancer. Experiments were carried out using cyclic voltammetry with HMDE as working electrode. The electrode reduction of the investigated compounds is quite irreversible and strongly dependent on pH. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Reference of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem